📰 GPCR Weekly News, September 4 to 10, 2023

Good day readers! Welcome to our latest GPCR updates.

This week's highlights:

• Dr. Yamina Berchiche, Founder and Director of Dr. GPCR, was featured as Superluminal Medicines Launches to Drug Protein Conformations in a Flash.

• Our partner, Domain Therapeutics, will attend the SACHS 23rd annual biotech event in Europe.

• Dr. Gregory Tall and team's study on GPR114/ADGRG5, activated by tethered-peptide-agonist, a cleaved adhesion GPCR.

• Dr. Christopher Langmead and colleagues' work on the 5-HT2C receptor as a therapeutic target for substance use disorders.

Save these dates:

• September 22: Join us for the Dr. GPCR Symposium on ''GPCRs as Therapeutic Modalities' Share your project with a 1-minute abstract video with this form.

• November 2 - 4: The GPCR Retreat is approaching and we are thrilled to be sponsors! Submit poster abstracts here; short talks will be selected from Abstracts. Abstract submissions close on October 2, and final registration ends on September 21.

Subscribe to the Dr. GPCR Newsletter for more insights!

Now, explore the Classified GPCR News from September 4th to 10th, 2023.

Adhesion GPCRs

• GPR114/ADGRG5 is activated by its tethered-peptide-agonist because it is a cleaved adhesion GPCR

• Latrophilin, an adhesion GPCR with galactose-binding lectin domain involved in the innate immune response of Tribolium castaneum

GPCR Activation and Signaling

• Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation

GPCR Binders, Drugs, and more

• Saturated Cannabinoids: Update on Synthesis Strategies and Biological Studies of These Emerging Cannabinoid Analogs

GPCRs in Neuroscience

• Serotonin signaling regulates actomyosin contractility during morphogenesis in evolutionarily divergent lineages

GPCRs in Oncology and Immunology

• [1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines

• Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors

Methods & Updates in GPCR Research

• Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats

Reviews, GPCRs, and more

• Understanding class B GPCR agonist binding

Structural and Molecular Insights into GPCR Function

• Structure and Molecular Mechanism of Signaling for the Glucagon-like Peptide-1 Receptor Bound to Gs Protein and Exendin-P5 Biased Agonist

• Molecular and structural insights into the 5-HT2C receptor as a therapeutic target for substance use disorders

Industry News

• Crinetics’ Once-Daily Oral Paltusotine Achieved The Primary And All Secondary Endpoints In The Phase 3 Pathfndr-1 Study Evaluating Treatment Of Patients With Acromegaly

• Crinetics Announces September 2023 Inducement Grants

• Click Therapeutics teams up with addiction treatment maker Indivior to make digital therapeutics for substance use disorders

• Superluminal Medicines Launches to Drug Protein Conformations in a Flash

• Andrew Hopkins, Exscientia's CEO, Recognized in TIME Magazine's for Pioneering AI-Driven Drug Discovery

• Domain Therapeutics CEO Pascal Neuville to Discuss Game-Changing GPCR-Targeting Immunotherapies at Sachs Associates' Biotech Forum

• Celtarys Research and G-CLIPS join forces to revolutionize transmembrane proteins characterization in drug discovery

• Confo Therapeutics Appoints Stephen Dowd As Chief Business Officer

• Septerna Announces Novel GPCR-targeted Program Acquired by Vertex

Call for GPCR Papers

• opnMe GPCR Route 66+ project. Deadline September 27, 2023

GPCR Events, Meetings, and Webinars

• NEW September 21, 2023 | Breaking Through the Barriers: Unlocking the Future of Ion Channel Drug Discovery with Cryo-EM

• September 25 - 28, 2023 | Discovery On Target

• September 27 - 28, 2023 | Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric Function and Biased Signaling" at the DOT

• October 3, 2023 | FREE Seminar: Changing paradigm on Therapeutics targeting Membrane Proteins: from antigen production to candidate validation

• October 25 - 27, 2023 | 3rd Annual Meeting IRN I-GPCRNet

• November 2 - 4, 2023 | GPCR Retreat

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 4, 2024 | Chemotactic Cytokines

GPCR Jobs

• NEW Senior Research Associate, In Vitro Pharmacology - Crinetics Pharmaceuticals

• NEW Postdoc In Cell Biology Of Protein Trafficking

• NEW Postdoctoral Fellow

• Researcher / Senior Researcher in Structural Biology

• Research Specialist

• Science Research Writer

• Postdoctoral Fellow

• Research Laboratory Specialist Associate

Explore Dr. GPCR Ecosystem