📰 GPCR Weekly News, February 26 to March 3, 2024

Welcome to our weekly GPCR Newsletter - your source for the latest insights, breakthroughs, and updates!

This week's highlight includes congrats to:

• Christina Katharina Kuhn, Drs. Sandra Berndt, Ines Liebscher, and Susanne Horn et. al for their for their research on adhesion GPCR transcript variants from publicly available human samples.

• Howard Rockman, and Dr. Robert Lefkowitz for their work on GPCRs: from radioligand binding to cellular signaling 

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Dr. GPCR Symposia

Mark your calendars! Next week, on March 15th, we are hosting a symposium on GPCR activation and signaling. We are delighted to confirm the participation of esteemed speakers such as Drs. Franziska Heydenreich, Sudarshan Rajagopal, Graham Ladds, Cesare Orlandi, Simone Prömel and Michel Bouvier. 

Additionally, we will be hosting a poster session in Zoom breakout rooms. If you want to share your work with our community, please don’t hesitate to fill out this form. We also value your feedback. If you attended our 2023 Symposia, please take a moment to complete this survey. 

Dr. GPCR University

Great News! The Dr. GPCR University Course, ‘Applying Pharmacology to Drug Discovery,’ led by Dr. Terry Kenakin, was a resounding success; we have a waitlist for those eager to attend this course, which wil be coming back later this year.

Mark your calendar; we’re planning a workshop for May 2024 with Dr. Sam Hoare as our instructor. With Dr. Hoare, you’ll learn how to analyze your data like a pro. Stay tuned for more information.

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 Dr. GPCR Partnered Events

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. 

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 Let’s dive into the Classified GPCR News from February 26th to March 3rd, 2024

Adhesion GPCRs

• The repertoire and structure of adhesion GPCR transcript variants assembled from publicly available deep-sequenced human samples

GPCR Activation and Signaling

• Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

• G protein-coupled receptors: from radioligand binding to cellular signaling

• GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism

• State-dependent dynamics of extramembrane domains in the β2 -adrenergic receptor

• β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR

• Bias translation: The final frontier?

• Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury

GPCRs in Cardiology, Endocrinology, and Taste

• RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms

• Phenylacetyl glutamine (PAGln) enhances cardiomyocyte death after myocardial infarction through β1 adrenergic receptor

GPCRs in Neuroscience

• Discovery of potential TAAR1 agonist targeting neurological and psychiatric disorders: An in silico approach

• Opioid modulation of prefrontal cortex cells and circuits

GPCRs in Oncology and Immunology

• RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway

• Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells

Methods & Updates in GPCR Research

• Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism

Reviews, GPCRs, and more

• Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)

• Will the hype of automated drug discovery finally be realized?

• Commentary: Analyzing invertebrate bitopic cadherin G protein-coupled receptors that bind cry toxins of Bacillus thuringiensis

Industry News

• Domain Therapeutics announces the promotion of Stephan Schann to the role of Chief Scientific Officer

• Crinetics Reports Fourth Quarter And Full Year 2023 Financial Results And Provides Corporate Update.

• Biagon Officially Incorporated In The State Of Illinois

• Septerna divulges new TSHR antagonists for hyperthyroidism

• Unlocking the Secrets of Cellular Communication: The Revolutionary Impact of Cryo-EM on GPCR Research  

GPCR Events, Meetings, and Webinars

• March 13 - 15 | Biologics 2024 

• March 13 - 15 | 9th German Pharm-Tox Summit 

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• Senior Scientist- Internal Medicine Research Unit

• Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology

• Research Fellow

• Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior 

• Director of Laboratory Operations - Single-molecule Imaging Center

• Scientific Assistant 

• Postdoctoral Fellowship- Mechanistic Biology 

• Research Scientist  

Join Dr. GPCR Ecosystem