📰 GPCR Weekly News, October 16 to 22, 2023

Hey there! Are you ready for some exciting news in the GPCR world?

This week's highlights:

• Dr. Bianca Plouffe and their colleagues' research on 'β-arrestin-dependent and -independent endosomal GPCR activation by the V2.'

• Norton Cheng and Dr. JoAnn Trejo's study 'identifies two deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses.'

• Dr. Robert J Lefkowitz and team's study 'GPCR signal transduction: β-arrestin activates ERK MAPK.'

• Dr. Thomas P. Sakmar and his team used 'bioluminescence resonance energy transfer to measure cell-surface expression of membrane proteins.'

Save the dates:

• November 2 - 4: We're sponsoring the GPCR Retreat and would love to meet you there! Submit your logo design by Nov 1st on the Logo Contest page. No registration is required to participate.

• November 17: Join our last Dr. GPCR Symposium of the year on GPCRs in Immunology and Oncology! We've gathered a panel of top experts for a roundtable discussion starting at 10 a.m. EST. Our confirmed speakers are Dr. Xavier Leroy, Dr. Brian Arey, and Dr. J. Silvio Gutkind. You can find more information about them on the Live Talks page and mark your calendar HERE.

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Check out the weekly Classified GPCR News from October 16th to 22nd, 2023.

GPCR Activation and Signaling

• β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

• An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses

• State-dependent dynamics of extramembrane domains in the β2 -adrenergic receptor

• Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin

GPCR Binders, Drugs, and more

• Pharmacologically targeting intracellular allosteric sites of GPCRs for drug discovery

• Targeting mGluR group III for the treatment of neurodegenerative diseases

GPCRs in Neuroscience

• Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling

• Ciliary localization of a light-activated neuronal GPCR shapes behavior

Methods & Updates in GPCR Research

• Advancements in the use of xenopus oocytes for modelling neurological disease for novel drug discovery

• Application of bioluminescence resonance energy transfer to quantitate cell-surface expression of membrane proteins

Structural and Molecular Insights into GPCR Function

• Molecular property, manipulation, and potential use of Opn5 and its homologs

Industry News

• The Leading GPCR Company in Immuno-Oncology, Domain Therapeutics, Presents Groundbreaking Advancements at ESMO 2023

• Novo Nordisk to Buy Hypertension Treatment from KBP Biosciences

• Exscientia to Present New Preclinical Data for AI-designed LSD1 and MALT1 Inhibitors at ESMO 2023

• Restoring the function of a human cell surface protein in yeast cells

• Trevena Reports Favorable TRV045 Topline Safety and Tolerability Data from Proof-of-Concept Studies

• Sosei Heptares’ President & CEO Chris Cargill Wins Executive of the Year at the Citeline Pharma Intelligence Awards Japan 2023

• BioMap and Sanofi to co-develop AI modules for biotherapeutic drug discovery

• Novartis Kisqali® NATALEE analysis reinforces consistent reduction in risk of recurrence across key subgroups of patients with early breast cancer

GPCR Events, Meetings, and Webinars

• October 25 - 27, 2023 | 3rd Annual Meeting IRN I-GPCRNet

• November 2 - 4, 2023 | GPCR Retreat- Registration Closed

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

GPCR Jobs

• Head of Human Resource Business Partners

• Senior Scientist, In vitro pharmacology - Crinetics Pharmaceuticals

• Senior Director, In vitro pharmacology - Crinetics Pharmaceuticals

• In vivo Antibody Discovery Research Scientist

• In Vitro Biologist/Molecular Pharmacologist

• Senior Vice President, Oncology Clinical Research

• Scientist (level I or II)

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