📰 GPCR Weekly News, August 21 to 27, 2023

Hi there GPCR minds! Join us for a deep dive into the world of GPCRs.

This week's highlights:

• Dr. Terence E. Hébert and their colleagues research on 'G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts'

• Dr. Sudarshan Rajagopal and their lab team study on 'Location bias: A "Hidden Variable" in GPCR pharmacology'

• Yao Lu and colleagues work on 'Molecular insights into orphan GPCRs relevant to schizophrenia'

• Carole Daly and their team research on 'β-arrestin-dependent and -independent endosomal GPCR activation by the V2.'

Save the dates:

• September 7 - 8: Join the 3rd ECI GPCR Symposium, an event by and for early career investigators in the GPCR field. Register by September 6, 12 pm EST.

• September 22: Don't miss the Dr. GPCR Symposium on 'GPCRs as Therapeutic Modalities'. Share your project with a 1-minute abstract video using this form. Our poster session is now a Kumospace discussion.

• November 2 - 4: The GPCR Retreat is approaching, and we're proud sponsors! Submit poster abstracts via this form; short talks will be selected. Early-bird registration deadline is September 8, abstract submissions close on October 2, and final registration ends on September 21.

Subscribe to Dr. GPCR Newsletter to receive more insights!

Now check out the weekly Classified GPCR News from August 21st to 27th, 2023.

GPCR Activation and Signaling

• G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts

• β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

GPCR Binders, Drugs, and more

• Altered G-Protein Transduction Protein Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia

GPCRs in Neuroscience

• Molecular insights into orphan G protein-coupled receptors relevant to schizophrenia

• Re-routing GPR56 signaling using Gα12/13 G protein chimeras

GPCRs in Oncology and Immunology

• Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant

• Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases

Methods & Updates in GPCR Research

• TrGPCR:GPCR-ligand Binding Affinity Predicting based on Dynamic Deep Transfer Learning

Reviews, GPCRs, and more

• Key Aspects of Modern GPCR Drug Discovery

• Location bias: A "Hidden Variable" in GPCR pharmacology

Structural and Molecular Insights into GPCR Function

• Structural bioinformatics studies of bacterial outer membrane beta-barrel transporters and their AlphaFold2 predicted water-soluble QTY variants

• Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain

Industry News

• Superluminal Medicines Launches with $33 Million Seed Round to Fuel its Drug Discovery Engine and Pipeline of Small Molecule Therapeutics

• Reproducibility of Tanso Biosciences' GPCR Assay

GPCR Events, Meetings, and Webinars

• August 31 - September 1, 2023 | ONCORNET2.0 Final Symposium

• September 7 - 8, 2023 | 3rd Transatlantic ECI GPCR Symposium

• September 25 - 28, 2023 | Discovery On Target

  • September 27 - 28, 2023 | Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric Function and Biased Signaling" at the DOT

• October 25 - 27, 2023 | 3rd Annual Meeting IRN I-GPCRNet

• November 2 - 4, 2023 | GPCR Retreat

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• NEW February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• NEW March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• NEW March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• NEW April 5 - 10, 2024 | AACR Annual Meeting

• NEW May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• NEW May 16 - 19, 2024 | ASPET 2024

• NEW May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• NEW June 2 - 4, 2024 | Chemotactic Cytokines

GPCR Jobs

• NEW Researcher / Senior Researcher in Structural Biology

• NEW Research Specialist

• NEW Science Research Writer

• Postdoctoral Fellow

• Research Laboratory Specialist Associate

• Postdoc Research Associate

• Director, Regulatory Affairs

• Research Scientist/Senior Scientist I - Molecular Pharmacology

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