Gloriam on orphan GPCR biology, GPCRDB, biased signaling, and how the data analysis bottleneck is reshaping He maintains and develops GPCRDB, a continuously updated database and tool platform that integrates structural , functional, and ligand data for the entire GPCR superfamily. The Human Genome as a Discovery Platform When Gloriam joined a bioinformatics group during his master's from sequence data 11:55 Orphan GPCRs - years spent chasing receptors with no known function or ligand

industry and the scientific community, with thousands of peer-reviewed publications and billions of data GPR75 MC4R NPY2R (PYY) SSTR5 Activins CALCR and RAMPs (AMYs) Apelin (APJ/AGTRL1) View representative data Together, these datasets exemplify the depth of pharmacological insight enabled by Eurofins DiscoverX platforms platform spanning the entire discovery and development continuum. These assays use the same platform as the Eurofins DiscoverX assays and beyond.

recombinant antibody platform built for specificity at scale Prioritized validation: CRISPR KO/KD, endogenous Interpretation pitfalls and what assay system choice does to bias estimates Translating pathway-level data Built for the GPCR community, by the GPCR community. GPCR event? Welcome. They're designed for scientists who want deep, data-driven discussion rather than surface-level overviews

pharmacology Data ❌ Suboptimal CRO Partnerships ❌ Stalled Pipeline Progression ❌ Uncertainty in GPCR to generate robust, decision-making data. Clear Platform Assessment: Gain rapid, independent insight into GPCR platform risks and true therapeutic assay platforms and in vitro models to deliver superior data quality and results. Biology-First, Data-Driven Solutions Every recommendation is rooted in GPCR biology, pharmacology experience

GPCR University. Sessions focus on scientific reasoning, data interpretation, and real discovery problems. platform to help train and inspire the next generation of scientists. About the GPCR Masterclass What is a GPCR Masterclass? Experts explain how they think about pharmacological data, experimental design, and discovery challenges—insight

Alexander Ball of GeneTex on the recombinant platform and validation strategy behind a challenge to GPCR GeneTex is tackling that problem with a high-throughput recombinant antibody platform paired with enhanced Inside the platform The production workflow is built to detect promising clones early and to hold specificity Ball will walk through how the recombinant platform was built, what it takes to produce specific antibodies Ball will walk through each, explain why KO/KD testing is prioritized, and show how the validation data

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currently leads Revvity's Research and Development activities, focusing on biochemical and cellular assay platforms ) and the Tag-lite platform. GPCR, the global nonprofit platform dedicated to advancing GPCR research and drug discovery, is proud Traditionally, studying it has meant long workflows, low throughput, or expensive imaging platforms. GPCR Podcast Oct 8, 2025 4 min read Innovative Data-Driven Solutions: The pHSense Revolution A powerful

He describes the experience with something between resignation and dry satisfaction: he knew, the data generated throughout his career originated in pattern recognition and intuition, before any supporting data He is careful not to overstate this: data drives decisions. and putting yourself out there 01:05:19 - Intuition as hypothesis generator: what comes before the data From there, you use the data to drive whether or not you're correct."

We Believe The Ecosystem was built with five key beliefs: Scientific rigor first This is a space for data-driven Our Journey (So Far) From the first podcast episode to a global platform, it's all built by and for the Platform Expanded beyond content to create a dedicated space for GPCR scientists to connect. 2023 First GPCR to: Curate relevant data—not overwhelm you with it Connect researchers with CROs, peers, and biotech pharmacology ✔ Sam Hoare, simplifying GPCR data analysis ✔ Global CROs and biotech leaders, contributing

(s) Sam Hoare: Receptor Residence Time and GPCR Data Analysis For most of GPCR pharmacology's history Sam Hoare brings a data analyst's perspective to GPCR pharmacology — one trained in allosteric modulation Hoare now consults for biotech and pharmaceutical clients on GPCR data analysis, receptor binding kinetics What he found was that clients arriving with a data problem are rarely arriving with just a data problem GPCR Member ResearchGate Dr. GPCR Ecosystem Unlock the Full Dr.

Pharmacology & Translational Models Advanced pharmacology and translational models for biologically relevant data experince 2,750+ validated functional and binding GPCR assays 300+ GPCR targets covered GPCRome broad coverage across the human GPCRome One integrated platform The full power of Eurofins Discovery These services are one part of an integrated GPCR platform. Products Eurofins DiscoverX Validated GPCR cell lines, assay kits, and custom products, on the same platform

R&D at Novo Nordisk before turning to systems biology approaches for connecting in vitro signaling data An MD-PhD who has practiced machine learning since 1989, he built Pharos, the public-facing data platform the Conversation The definitional boundary between AI, machine learning, and computational modeling Data The barrier isn't messy data — it's missing metadata. The explosion of biomedical data such as in genomics, structural biology, and pharmacology can provide

GPCR webinars are live online scientific sessions focused on G protein-coupled receptor (GPCR) biology These webinars are designed for scientists who want deep, data-driven discussion rather than surface-level GPCR platform. Do I need prior knowledge of GPCR pharmacology? Are these GPCR webinars free? Yes. All live GPCR webinars are free to attend. GPCR Ecosystem as a free member.

Bouvier on BRET, pharmacological chaperones, biased agonism, and why unexpected data is where real GPCR mutants, and biosensor platforms that helped establish functional selectivity and biased agonism as CONVERSATION The limits of the binary receptor model and what inverse agonism revealed BRET technology as a platform A high-impact journal accepted the GPCR dimerization data but required evidence in living cells - which GPCR Podcast? Leave a Review.

Ilana Kotliar built a multiplexed platform to map GPCR-RAMP interactions and uncover autoantibody-driven The result: a scalable platform to analyze hundreds of interactions with minimal sample usage. This could accelerate discovery of therapeutic targets by combining multiplex data with focused downstream Instead of focusing on a single receptor, students now gravitate toward platforms , biosensors , and data-rich assays .

of practical knowledge GPCR researcher The best pharmacology teacher teaming up with the best GPCR community platform to help train and inspire the next generation of scientists. GPCR researcher About the GPCR Masterclass What is a GPCR Masterclass? The GPCR Masterclass is a live scientific discussion with a leading expert in GPCR pharmacology, receptor Experts explain how they think about pharmacological data, experimental design, and discovery challenges—insight

GPCR Foundry: Accelerate GPCR Drug Discovery Move from idea to insight—faster, smarter, and with confidence Kenakin's weekly insights and AMAs — building shared language around GPCR data and pharmacological decisions Translates complex GPCR pharmacology into practical understanding you can apply to data interpretation Real-world case studies and data-driven models for pipeline prioritization, resource allocation, and GPCR ecosystem.

Officer and co-founder of InterAx Biotech, where he specializes in the development of a technology platform Rizk, a co-founder and CEO of Interax Biotech, shared about the company's development of a discovery platform interdisciplinary nature of his company, which includes mathematics, signaling pathways, a wet lab for data They also discussed the challenges of system dependency in data and the need to express data in a uniform GPCR Podcast? Leave a Review.

Twist's silicon platform produces pools of discrete, designed sequences — a shift in how synthetic libraries Eight to ten weeks from a GPCR target to a functional IgG is the platform's working tempo, not a best He looks for target classes where existing platforms have already failed — not because the biology is crystallography to leading Twist Biopharma 04:21 Twist Bioscience, Twist Biopharma, and the silicon DNA platform 08:12 Using DNA for long-term data storage — a parallel vertical 09:17 Why antibodies to GPCRs have

service offerings in one trusted location Support inbound inquiries from teams actively evaluating CROs, platforms Featured across our nonprofit platform, trusted by thousands As a CRO partner, you'll be featured across our nonprofit platform, trusted by thousands of GPCR scientists and biotech professionals. Connect with scientists who are actively looking for tools like yours, without the noise of general platforms Distributed across podcast platforms and social media.

Transform your biotech idea or data into a clear, strategic roadmap with aligned biology, timelines, Take your idea, platform, or early data and turn it into a strategic roadmap with clear decisions, timelines How I Help Biotechs Accelerate GPCR Discovery with Clarity, Speed & Confidence Decisions, Not More Data GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr. GPCR Corp Proudly created with Wix.com

At UCSF, he develops structural models of GPCRs using sparse experimental data - combining restraints His research focuses on predicting GPCR structural ensembles from limited experimental data and using That period of laborious, close-range data inspection became the conceptual foundation of his pan-GPCR computation - how the path began 05:47 Modeling GPCR conformational ensembles from sparse data 07:44 Brain’s work there primarily focused on structure prediction of GPCRs from sparse experimental data.

GPCR constructs Experimental–computational feedback loops in receptor biology Data quality and annotation of GPCR signaling pathways Key Insights from the Conversation Experimental Data Drives Computational ChimeraDB and Data Challenges The challenge of collecting standardized data on chimeric GPCR experiments We don't generate the original data ourselves—we analyze and build models based on experimental data. One of the challenges I faced early in my PhD was collecting data on previously published chimeric GPCR

specificity across all 10 human frizzled subtypes, receptor conformational dynamics, and biosensor platforms The frizzled family is commonly discussed as a single target class, but Schulte's G-protein coupling data lesson in pharmacological humility that lasted 25 years During his thesis seminar, Schulte presented data GPCR Ecosystem Unlock the Full Dr. GPCR Podcast? Leave a Review.

Advance your GPCR research career with Dr. GPCR University. GPCR University Your professional home in GPCR science. in the GPCR field. field GPCR researcher The best pharmacology teacher teaming up with the best GPCR community platform GPCR University is an educational platform that provides in-depth learning and training resources on

Denmark's CPR number system links psychiatric diagnoses, prescription histories, genotypes, and demographic data , not a strategy Hauser traces his integrative approach - bridging structural biology, evolutionary data pharmacogenomics, and precision psychiatry 06:47 - Denmark's iPSYCH biobank and what makes nationwide registry data unique 09:15 - GDPR, unconsented patient data, and the ethics of population-scale research 10:14 - Origin Alexander has a big interest in the integration of large biomedical data in genomics, structural biology

, and the importance of team composition, negative data, and scientific community in navigating complex electrophysiology, molecular pharmacology, and the use of informatics to mine sequence, structural, and genetic data turned out to be the real agonist, and a nicotinic acid receptor by intersecting tissue expression data Foord emphasizes how easy it is to be misled by overexpressed systems and noisy orphan receptor data. work you enjoy, the importance of mentors and connectedness, and how team composition and negative data

named after condiments, ketchup, mayo, and remulate, not out of irreverence, but because no functional data with no prior functional data Genetic tools for adhesion GPCR research in Drosophila, CRISPR, epitope The other three had no documented expression pattern, signaling data, or phenotype. where the field actually stands Ketchup, Mayo, and Remulate were named in the absence of functional data Some journals are beginning to accept negative data, and both agree this matters structurally.

GPCR community. Become our Brand Ambassador Our vision is to build the best platform for the GPCR community and help articles about their favorite GPCR topics and sharing these on social media platforms such as LinkedIn GPCR Ecosystem? It will be a remarkable journey and fun to build together the "next-generation" platform for the B2B