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Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights . << Back to podcast list Strategic Partner(s) Leadership, Impact, and GPCR Signaling with Dr. Michelle Halls shares how dissecting the spatial organization of GPCR signaling opens new doors in drug Inside This Episode How ultrasensitive GPCR signaling emerges from pre-assembled receptor–effector complexes Spatial Signaling Sparked a Scientific Journey From Pipettes to Platforms: The Evolution of GPCR Research

in Jeff Benovic’s laboratory studying the regulation of G protein-coupled receptor trafficking and signaling Adriano’s research has contributed to our understanding of the role that ubiquitin plays in GPCR signaling His lab has shown a role for -arrestins and PTMs in GPCR trafficking and signaling and has leveraged this knowledge to reveal the spatial and temporal requirements for GPCR activation of signaling pathways The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic

Explore GPCR signaling kinetics and temporal drug action mechanisms with Sam Hoare. . < Back How Signaling Kinetics Shapes GPCR Drug Action May 14, 2026 10 AM - 11:30 AM EST 🔒 Watch Recordings Introduction GPCR signaling kinetics, the temporal dynamics of receptor activation and downstream signaling session addresses the clinical landscape of kinetic-dependent drug action, biosensor-based measurement of signaling Pharmechanics LLC, specializing in kinetic analysis of drug action and the application of binding and signaling

Explore how subcellular location and temporal dynamics revolutionize GPCR signaling through nanodomains Introduction Classical GPCR signaling models assumed uniform receptor distribution and immediate signal Contemporary research reveals that subcellular location and temporal dynamics fundamentally determine signaling This session examines how receptor nanodomains, endosomal signaling compartments, and biomolecular condensates create distinct signaling environments that prevent crosstalk and enable pathway specificity.

Keyvan Sedaghat. << Back to podcast list Strategic Partner(s) How Lipid Rafts Organize GPCR Signaling from his research on D1 receptor desensitization and GRK isoform signaling. GPCR Premium. Why This Matters How lipid raft microdomains selectively regulate GPCR signaling and internalization protein-coupled receptors and D1 receptor regulation—work that sparked his ongoing engagement with receptor signaling

Explore how GPCR signaling shapes mosquito feeding and mating behaviors with Dr. Laura Duvall. How GPCR-mediated neuropeptide signaling dictates mosquito attraction to humans, directly impacting disease What functional and behavioral assays in mosquitoes reveal about the underlying diversity of GPCR signaling If you are interested in how behavioral outcomes emerge from cell-type-specific GPCR expression and signaling signaling.

) signalling and their alterations in endocrine, metabolic and cardiovascular diseases. To study GPCR signalling, they develop and use innovative optical methods based on FRET and single-molecule microscopy, which allow them to directly observe signalling events in living cells and tissues with GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Discover how GPR65 reshapes our understanding of GPCR signaling and its role in cancer, with Dr. GPCR podcast. << Back to podcast list Strategic Partner(s) Signals, pH, and Discovery : Cracking GPCR This dual functionality—environmental sensing and compartment-specific signaling—offers a new layer of signaling , and the importance of engaging with the broader GPCR research community to drive innovation My research has looked at the trafficking and signaling of adrenergic and proton-sensing receptors, with

Anita Nivedha: Computational Dynamics of Ligand Bias in GPCR Signaling Scientific Abstract G protein–coupled receptors (GPCRs) transmit extracellular signals through conformational changes that propagate from Anita Nivedha discusses computational approaches to decoding signal propagation within GPCR structures Her work focuses on understanding how ligand binding propagates structural signals through GPCRs using and the challenge of tracing signal propagation within GPCR structures. 02:00 — Scientific background

<< Back to podcast list Strategic Partner(s) Developing new tools to uncover GPCR signaling patterns My particular projects revolve around developing new tools to study GPCR activity in ways that were not /G protein signaling which I would be happy to discuss. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Terry Hebert on why challenge trials weren't ready, what it takes to hold a GPCR signaling lab together The discussion moves across three scientific registers: the practical mechanics of holding a GPCR signaling His research spans BRET-based assay platforms for characterizing signaling downstream of specific GPCRs BRET platforms for GPCR signaling — The role of resonance-energy-transfer-based assays in capturing signaling Much of his work is based on GPCR signaling in the context to cardiovascular diseases.

Paul Insel turned dry-lab science into a reframing of COVID-19 pathobiology as a GPCR signaling imbalance Paul Insel: Rethinking COVID-19 Pathobiology Through GPCR Signaling In the spring and summer of 2020, What came next was a series of papers reframing severe COVID-19 as a disease of signaling imbalance: His research career has centered on GPCR signaling — with particularly deep work on beta-adrenergic receptors Severe COVID-19 may be a story of signaling imbalance, not just viral damage.

she obtained her Ph.D. at the University of Western Ontario, working on the regulation of G proteins signaling Her current research focuses on class B GPCRs and understanding how GPCR signaling and function is mediated Join me to learn more about Elva, class B GPCRs, and Tilly. Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

focused on developing new pharmacological tools via chemistry and protein engineering to interrogate GPCR signaling. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

His group studies the unusual signaling mechanisms employed by these atypical 7-transmembrane receptors More recently, Ben’s lab has begun studying GPCR signaling pathways that operate within the primary cilium Ben studied developmental and cancer signaling as a postdoctoral fellow with Philip Beachy at Stanford GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Dylan's graduate research focuses on the mechanisms underlying biased signaling at GPCRs, specifically , the role of differential receptor phosphorylation (phosphorylation barcodes) and subcellular GPCR signaling GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Still working on GPCR trafficking but this time in neurons. signalling and trafficking in neurons using microscopy and proteomics based techniques. " Dr. GPCR Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors contributions to the field and expand our understanding of GPCR signaling." GPCR Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

signaling and beta-arrestins in diabetes and obesity. ) by exploring metabolically important signaling pathways in immune cells and insulin-sensitive tissues Sai Prasad Pydi on the web Molecular Metabolism & Cell Signaling Laboratory Website Twitter.com Research GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

she identified novel core cellular machinery critical for G protein-coupled receptor trafficking and signaling , including spatial control of GPCR signaling and receptor crosstalk, and applying these mechanisms for GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Enjoying GPCR Podcast? Leave a Review.

Terry Kenakin ’s hands-on workshop, The Practical Assessment of Signaling Bias . Didn’t sign up? obesity drug discovery: Cell-based assays for GLP-1 and the G-Suite March 17 - 21, 2025 | 2nd GPCR signaling mechanosensing GPCR Activation and Signaling Lineage-Specific Class-A GPCR Dynamics Reflect Diverse in Cardiology, Endocrinology, and Taste N-homocysteinylation of β-arrestins biases GPCR signaling and Signaling toward Arrestins Structural and Molecular Insights into GPCR Function A combined in silico

Tore Bengtsson on β₂-adrenergic receptor signaling, muscle metabolism, and how GPCR pharmacology can The conversation also examines how GPCR signaling is far more complex than a single downstream pathway GPCRs Do Not Produce a Single Signal Dr. Bengtsson highlights that GPCR signaling is inherently multidimensional. But GPCRs activate multiple signaling pathways simultaneously.

Specifically, I am interested in understanding dysregulated G-protein coupled receptor (GPCR) signaling My long-term plan is to conduct research in the field of receptor biology, with a focus on GPCRs. GPCR Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

she identified novel core cellular machinery critical for G protein-coupled receptor trafficking and signaling , including spatial control of GPCR signaling and receptor crosstalk, and applying these mechanisms for GPCR About Dr. Caroline Gorvin "Dr. Caroline continued to undertake postdoctoral research in Oxford, investigating the signalling and trafficking GPCR Podcast? Leave a Review.

of what we know about GPCR signaling was learned in HEK293 cells — a system that reveals what is possible Hebert's research focuses on the angiotensin AT1 receptor, a signaling hub coupled to Gq, Gi, G12, and His research centers on GPCR signaling networks, biosensor development, and the role of cellular context His contributions span GPCR dimerization, nuclear receptor signaling, and the emerging role of G-proteins of signaling pathways.

How advanced assay design is essential for translating cell-based GPCR signals to therapeutic outcomes Why strategic flexibility in exploring non-canonical signaling pathways is critical for GPCR-targeted Researchers refining strategies for high-throughput screening or exploring biased signaling. field and became proficient in aptamer selection and cell signaling assays. GPCR Podcast? Leave a Review.

His research spans four decades of GPCR signaling, from cyclic AMP and adrenergic receptor biology to The tumor signals fibroblasts to raise GPR68 expression, and the low pH of the tumor microenvironment then activates that receptor, which signals back to promote cancer survival. Biased signaling is real but harder to exploit than expected GPR68 couples to both Gq and Gs, and the That accidental assignment launched a career in GPCR signaling that has now spanned over four decades

receptors regulate metabolism across the pancreas and brain, and why visualizing receptor localization and signaling in real tissues is essential for advancing GPCR drug discovery . signaling in metabolic tissues What collaborative chemistry enabled in designing receptor-targeted fluorescent GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

years in early R&D at Novo Nordisk before turning to systems biology approaches for connecting in vitro signaling signaling pathways. computational cost of molecular dynamics simulations needed to capture the dynamic conformations behind signaling 37:01 Reading GPCR signaling dynamics with computational models 39:53 Generative models, scoring functions structure prediction, bioactive ligand discovery, in-vivo translation ability, or in our understanding of signaling