Tom Sakmar didn’t set out to map GPCR-RAMP interactions across hundreds of receptors. , multiplexed platform to investigate GPCR-RAMP biology  like never before. and an online platform to query GPCR-RAMP interaction data and antibody validations. & orphan GPCRs Identify new accessory protein interactions Build disease-relevant signaling models Validate interactions , Family B GPCRs , GPCR scientist network , GPCR data platform , Dr.

species-specific pharmacology Deorphanize receptors and identify new ligands Run functional and binding assays (cAMP GPCR. GPCR Dr. GPCR empowers scientists and organizations advancing GPCR biology and GPCR-targeted drug discovery. GPCR's educational programs and global GPCR community, visit https://www.ecosystem.drgpcr.com/gpcr-university

GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. features a discussion about a scalable GPCR-RAMP assay. Their global resource is now helping labs decode GPCR biology at scale. It’s exciting to see how the GPCR field is evolving. GPCR Team

Ilana Kotliar built a multiplexed platform to map GPCR-RAMP interactions and uncover autoantibody-driven interactions. The team developed two main assets: A web interface to visualize antibody validations and GPCR-RAMP interactions Beyond GPCR-RAMP: New Avenues “What if your favorite scaffold protein interacts with GPCRs?” – Tom Sakmar The constructs aren’t limited to RAMP interaction studies.

Hay on class B GPCRs, RAMPs, and the selectivity problem in CGRP-targeted migraine therapies - what the , RAMPs, and the Migraine Pharmacology Gap Class B GPCRs represent one of the smaller subfamilies in and calcitonin-like receptor - and their interactions with RAMPs. pharmacology 07:55 First encounter with GPCRs at GlaxoWellcome - and how RAMPs entered the picture 11 Her work is primarily focused on class B GPCRs and their interactions with RAMPs.

Foord reflects on discovering RAMPs, deorphanizing GPCRs, and navigating industrial GPCR pharmacology validation, and drug discovery strategy. << Back to podcast list Strategic Partner(s) Foord: Serendipity, RAMPs , And Industrial GPCR Pharmacology Scientific Abstract This conversation traces how GPCR pharmacology Key Insights from the Conversation RAMPs Reframed Peptide GPCR Pharmacology . Dr. The discovery of RAMPs was only possible because the assay tied receptor signaling to a highly amplified