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Tom Sakmar didn’t set out to map GPCR-RAMP interactions across hundreds of receptors. , multiplexed platform to investigate GPCR-RAMP biology  like never before. and an online platform to query GPCR-RAMP interaction data and antibody validations. & orphan GPCRs Identify new accessory protein interactions Build disease-relevant signaling models Validate interactions , Family B GPCRs , GPCR scientist network , GPCR data platform , Dr.

GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. features a discussion about a scalable GPCR-RAMP assay. Their global resource is now helping labs decode GPCR biology at scale. It’s exciting to see how the GPCR field is evolving. GPCR Team

Hi GPCR Enthusiasts (and Arrestin Aficionados!)   This week at Dr. of GPCR-RAMP discovery. GPCR Updates   Advanced Methods for the Optimization of Candidate Selection  – Master GPCR behavior beyond Ilana Kotliar share how three decades of curiosity evolved into a tech-powered platform for mapping GPCR-RAMP interactions.

But your GPCR program still isn't moving at the pace it should. The GPCR Data Dilemma: The Lego Bucket Problem I've seen promising GPCR programs generate massive volumes GPCR As the co-founder of Dr. GPCR, we've built a global hub connecting over 1,300 GPCR scientists dedicated to this field. Ready to Move Your GPCR Program Forward?

The ability to identify compounds that interact with molecular targets involved in disease pathways is This technique is most effective at studying interactions between large proteins and small ligands thanks Compatible with various sources of GPCRs. Contact us  to drive further advancements in GPCR drug discovery!   Exploring Non-orthosteric Interactions with a Series of Potent and Selective A3 Antagonists.

Recognizing, predicting, and leveraging these interactions is the essence of enzyme inhibition pharmacology This lesson reframes enzyme interaction not as background noise, but as a core pharmacological event. And responsible for countless drug–drug interactions. When Inhibition Becomes Activation Not all enzyme interactions are suppressive. Kenakin with your own enzyme or GPCR interaction puzzles.

That perspective changed the moment he entered GPCR research . : training the next generation of GPCR scientists . The GPCR Challenge What makes collaboration non-negotiable in GPCR research is the biology itself. GPCR Models Don’t Discover Drugs—People Do In GPCR research, the biggest breakthroughs won’t come from GPCR Podcast 🌱 Build a career with purpose, not just papers The Dr.

as they can be used to determine receptor activation dynamics, ligand binding geometry and receptor interactions This means fluorescent probes enable a dynamic observation of GPCRs. common starting point for employing fluorescent probes in GPCR assays. Fluorescent ligands: Bringing light to emerging GPCR paradigms. Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors.

GPCRs are present in a range of conformations, and the binding of a ligand, as well as interactions with GPCR targeting drugs: orthosteric vs allosteric sites Most of the drugs targeting GPCRs bind to the orthosteric GPCRs functional selectivity Recent research has revealed a more intricate understanding of GPCR behavior Depending on the specific functional outcome measured (e.g. activation, interaction with accessory proteins selectively activate specific cellular outcomes linked to that GPCR.

Is Your GPCR Program Slowing Down—Even With Good Data? You’re not alone. GPCR Ecosystem. Strong science. Promising data. But no systems to turn it into momentum. GPCR, I’m connected to 1,300+ scientists and decision-makers worldwide. Who I Work With ✅ Biotech Teams  – Especially those lacking in-house GPCR leads or overwhelmed by CRO data chaos. ✅ Venture Capital Firms  – Looking to accelerate, troubleshoot, or validate GPCR assets

That’s exactly why we created GPCR Happy Hour . GPCR’s nonprofit mission to unite and empower the GPCR community worldwide FOMO is real: if you’re not Be Part of the GPCR Community Dr. GPCR is a nonprofit global community  dedicated to building a strong, connected GPCR ecosystem. GPCR Happy Hour is more than a social event.

mutated GPCRs. Plus: top tracks to watch at GPCR Forum 2025, fresh postdoc openings at the ADME/signaling interface , and concise reads on β-agonists, phospho-barcodes, and GPCR allostery. Mastering inhibition isn’t just about avoiding drug–drug interactions. The pace of GPCR innovation is accelerating.

GPCR and Revvity. But there was a pivot: the tech had untapped potential for GPCRs. Why This Matters: The GPCR toolkit scientists use today—cAMP, IP-One, and now pHSense—didn’t evolve incrementally GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

space focused on GPCR pharmacology. – GPCR mutations in cancer—drivers, passengers, or both?  GPCR Updates Learn Pharmacology That Drives Discovery  – From Dr. GPCR Podcast appearance. GPCR Team

s latest lecture delivers high-impact insight crafted for teams navigating the complex behaviors of GPCR-targeting As Kenakin explains, all GPCR signaling is allosteric , and pretending otherwise introduces risk at every probe dependence : the idea that the effect of an allosteric modulator depends entirely on the probe it interacts But without understanding how GPCR state changes  influence that affinity—or vice versa—drug discovery Corner  is your trusted, expert-led guide through the evolving landscape of GPCR science.

Welcome GPCR Fans,   In GPCR-targeted drug discovery, precision isn’t optional—it’s a requirement. GPCR Premium Members this week gain curated, early access to: Industry insights : GPCRs and mRNA in drug The interpretation of high and low affinity binding sites on GPCRs. GPCR Premium Membership Gives You an Edge Dr. GPCR Premium gives you an edge in a fast-moving field.

Get your space suits on, GPCR cadets! up with a series of cosmic GPCR events for the year ahead. Discounted GPCR courses - because who doesn't love a good deal?  From 2025, only Premium Members will have access to Classified GPCR News. Classified GPCR News  Let’s dive into the   Classified GPCR News from October 28th to November 3rd, 2024

The central role of GPCRs in Neurological Disorders GPCRs are the largest family of membrane receptors Over 30% of FDA-approved drugs target GPCRs, with many targeting CNS located GPCRs. They manage this by interacting with G-proteins. What happens when a GPCR is activated? Depending on the type of GPCR, it can lead to different secondary messengers , like cAMP, IP3, which Some of the advantages of using fluorescent ligands for this are: Live-cell imaging:  receptor-ligand interactions

Hello GPCR Enthusiasts, Interpreting binding data isn’t optional—it’s career-defining. GPCR Premium: Sneak Peek Every week, Premium Members get curated intelligence they won’t find in open Read the article now ➤ Discovery on Target - The Next Wave of GPCR Drug Discovery The 20th Annual GPCR-Based GPCR Premium Membership Gives You an Edge The GPCR field is advancing at breakneck speed. The pace of GPCR innovation is accelerating.

Many GPCR scientists trace their origin story back to a single unexpected spark. Not a grand plan. Luck, Leadership & GPCR Signaling Michelle is clear: luck played a role. But so did choice. Her work sits at the intersection of fundamental biology and therapeutic strategy. GPCR Podcast 🔓 Want to go deeper? Join   Dr. GPCR Premium  for exclusive tools, deep dives, and expert access.

Welcome GPCR Fans,   Every discovery-phase decision you make shapes your entire pipeline trajectory—and Upcoming events:  5th MMCS New Trends in Drug Discovery; GPCR-UK Network Meeting; neuroGPCR Symposium Must-read publications:  GPCRchimeraDB: Database of engineered GPCR designs. GPCR University Course Attendee Dr. The pace of GPCR innovation is accelerating.

Enhance your GPCR research with deeper assay insights for more effective results. This Week’s GPCR Intelligence: If you want cleaner decisions, start with the system—then the ligand. Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates allosteric site on an orphan GPCR. 🔍 This Week in Dr. GPCR innovation is accelerating.

Eric Trinquet, a veteran innovator behind functional GPCR assays like HTRF and IP-One, believes rigid If you’re building tools or careers in GPCR science, this is your playbook. It began with an unmet need: how to track Gq-coupled GPCR activity without the mess of calcium flux or GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

Watch Episode 175 From failed assays to breakthroughs in GPCR modeling , Dr. Discovering Modeling (and GPCRs) by Accident That interest led him to pursue a thesis at Scripps Research At that point, very few GPCR crystal structures had been determined. With limited structural data but a growing pharmacological interest, GPCRs presented the perfect challenge For Carlsson, this marked a shift in how his lab approached GPCR research.

Listen to the episode ➤ Quick Links Assess GPCR Biased Signaling of Agonist How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling GPCR Premium Membership Gives You an Edge Premium delivers a clear, noise-free stream of GPCR intelligence GPCR innovation is accelerating. GPCR Team

GPCR Ecosystem. , Tag-lite® G-protein activation  – cAMP, IP-One, GTP assays β-arrestin recruitment assays Downstream GPCR Podcast To mark the spotlight, Dr. GPCR  invited Dr. Eric Trinquet  to the Dr. GPCR. GPCR Dr.

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR. Dear Dr. GPCR, it was with a simple goal: to connect people who shared a passion for GPCR science and discovery GPCR Foundry  — our R&D and biotech hub designed to bridge GPCR science with execution. The Dr. GPCR resources, connect new scientists, and earn rewards  for helping expand access to GPCR knowledge GPCR About Dr. GPCR Dr.

GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

In the high-stakes world of GPCR drug discovery , breakthrough science isn't enough. GPCR, we recognized this core problem. This is the essence of de-risking GPCR programs through operational excellence. the entire GPCR program as a single, interconnected entity. The GPCR Precision Blueprint is more than a concept.