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Professor Deane joins Exscientia’s technology leadership team, reporting to Chief Technology Officer, Garry Pairaudeau.

GPCR-targeting antibodies GPCR Inhibition With ICB May Be Needed to Reactivate Antitumor Immune Response Garry Pairaudeau, CTO of Exscientia discuss transforming drug discovery using their AI-driven platform Salipro

The Steady-State Cancellation Problem A scaffold carrying both agonist and antagonist activity presents The peptide sequence carries a region responsible for efficacy and a separate region that functions as When a scaffold carries both activities, kinetic assays produce complex time-dependent response curves A scaffold that reads as inactive under standard screening conditions may carry multiple activities that

biochemical mechanisms of flavonoids in cancer using nuclear magnetic resonance spectroscopy (NMR) led to a Barry

Nicholas Holliday After an undergraduate degree at the University of Cambridge, Nick carried out his

orthosteric ligands within their transmembrane domain and can function as monomers, class C receptors carry - what it enabled and what it still cannot resolve KEY INSIGHTS FROM THE CONVERSATION Class C GPCRs carry Dimerization is not optional - it is the mechanism GABA-B is an obligate heterodimer: the GABA-B1 subunit carries It is used to treat muscle spasticity in multiple sclerosis and spinal cord injury, but it carries significant