Professor Deane joins Exscientia’s technology leadership team, reporting to Chief Technology Officer, Garry Pairaudeau.

GPCR-targeting antibodies GPCR Inhibition With ICB May Be Needed to Reactivate Antitumor Immune Response Garry Pairaudeau, CTO of Exscientia discuss transforming drug discovery using their AI-driven platform Salipro

The Steady-State Cancellation Problem A scaffold carrying both agonist and antagonist activity presents The peptide sequence carries a region responsible for efficacy and a separate region that functions as When a scaffold carries both activities, kinetic assays produce complex time-dependent response curves A scaffold that reads as inactive under standard screening conditions may carry multiple activities that

orthosteric ligands within their transmembrane domain and can function as monomers, class C receptors carry - what it enabled and what it still cannot resolve KEY INSIGHTS FROM THE CONVERSATION Class C GPCRs carry Dimerization is not optional - it is the mechanism GABA-B is an obligate heterodimer: the GABA-B1 subunit carries It is used to treat muscle spasticity in multiple sclerosis and spinal cord injury, but it carries significant

SCIENTIFIC ABSTRACT Receptor pharmacology spent decades describing a drug as if a single number could carry protein versus screening the whole phenotype - Translation: why bias is easy to measure and hard to carry Seeing that a drug could carry more than one efficacy, he says, shattered a model he had felt secure

Gutkind — carrying a personal loss in New York and leading a cancer center building that operated at Because trainees rotate through multiple labs, they carry science from one bench to another. Dr. "These rotation students are like cross-pollination… almost like the sorting hat in Harry Potter."