September 2022 Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS for the existence of a functional gonadotropin-inhibitory hormone (GnIH) system in the European sea bass Herein, we further elucidated the intracellular signaling pathways mediating in sea bass GnIH actions and the potential interactions with sea bass kisspeptin (Kiss) signaling. These data indicate that sea bass GnIHR signals can be transduced through the PKA and PKC pathways, and

August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (NAFLD) have yet to be fully delineated and only a single drug, peroxisome proliferator-activated receptor (PPAR) α/γ agonist saroglitazar, has been approved. Here, we sought to investigate the role of Regulator of G Protein Signaling 7 (RGS7) in hyperlipidemia-dependent hepatic dysfunction. " Read more at the source #DrGPCR #GPCR #IndustryNews

Gaining control over disease-related events in non-alcoholic steatohepatitis (NASH), an advanced form Hepatic fibrosis is a critical prognostic factor in NAFLD/NASH. regulate liver fibrosis, may lead to the development of drugs that can improve hepatic fibrosis in NAFLD/NASH roles in liver fibrogenesis, and finally speculate on the development of novel treatments for NAFLD/NASH

Jason Nasse About Dr. Jason Nasse Dr. Jason Nasse is a senior scientist at Addgene specializing in the use of AAV viral vectors. Nasse has had the opportunity to experience how science is performed across different sectors and around Jason Nasse on the web LinkedIn Dr.

Jason Nasse; Dr. Sudha Shenoy, and Dr. Thomas P. Sakmar Dr.

metabolic diseases including Type 2 Diabetes and other indications including non-alcoholic steatohepatitis (NASH