Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.

January 2022 "OXFORD, England--Professor Charlotte Deane, Ph.D., of the University of Oxford, has joined Professor Deane joins Exscientia’s technology leadership team, reporting to Chief Technology Officer, Professor Deane is one of the UK’s most accomplished bioinformaticians. Prior to this, Professor Deane was Deputy Executive Chair of the Engineering and Physical Sciences Research Professor Deane holds a B.A. in Chemistry from the University of Oxford and a Ph.D. in Biochemistry from

.- Jan Steyaert, scientific director of the VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie Jan Steyaert will be presented with the Gabbay Award at Brandeis University on October 27 when he will

Pina Cardarelli, CSO of GPCR Therapeutics.

The €25 million fundraising gives us the means to achieve our ambitions: to become a leading player in

Results: Acute stimulation of GsD signaling in SKM impaired glucose tolerance in lean and obese mice Clenbuterol injection improved glucose tolerance by increasing insulin secretion in lean mice.

acts as a functional component of Cya, guiding the assembly of the catalytic domain and providing the means

Finally, we explore what such connections between the cell surface and nuclear GPCR signaling might mean

While limited, human studies infer differential regulation of the PKA system in obese compared to lean

By means of these studies, we developed 14 as a fluorescent CCR2 ligand, enabling cell-free as well as

November 2021 "Target class-specific libraries mean you need to screen less to identify high-quality

By means of molecular dynamics we explained why C5aR2 cannot transduce signal through the G protein pathway

predicted models were then aligned with the experimentally solved structures and evaluated by the root-mean-square

Unified Huntington's Disease Rating Scale (UHDRS®) Total Maximal Chorea (TMC) Score- Placebo-Adjusted Mean

Methods & Updates in GPCR Research Profiling of basal and ligand-dependent GPCR activities by means of

to optimize transmembrane domain providing significantly increased binding affinity and providing a means molecules in the library are specific for the target receptor rather than irrelevant cell surface targets, meaning Since shape space exploration is specifically focused on the ‘message’ site in the TM domain, this means This leads to strikingly long in vitro receptor occupancy durations (at least seven days), meaning that

Financial Expectations for 2024 Domain Therapeutics further strengthens leadership team with appointment of Sean

Drug Discovery Nexus Salipro Biotech will participate in BioKorea2024 Domain Therapeutics Appoints Sean

., combatting the opioid overdose epidemic has become a mean challenge for the scientific community. Biochem Biophys Res Commun. 2023 Jan 15;640:64-72. doi: 10.1016/j.bbrc.2022.11.098.

Inês Pinheiro and Oliver Hartley from the Orion Biotechnology team on their recent study on Arylsulfatases

Pinpointing signaling pathways governed by β-arrestins, which exhibit increased or reduced activity within

Devki D Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic

Expectations, EPS Lags “As Precision Medicine is critical, we cannot think about one size fits all” Dr Pina

Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery.

Industry News Josephine (Pina) Cardarelli from GPCR Therapeutics on Beyond Biotech Podcast Crinetics

Ping, Y.-Q., et al., Structural basis for the tethered peptide activation of adhesion GPCRs.

Additionally, we detect a shortening of PC in PINK1-deficient human cellular and mouse models of familial

Identification and functional characterization of the sulfakinin and sulfakinin receptor in the Chinese white pine However, there is no report on the functional role of SK in the Chinese white pine beetle, Dendroctonus