📰 GPCR Weekly News, May 1 to 7, 2023

Good day readers! We've got some GPCR updates to share with you. Take a look 👀!

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Below is your Classified GPCR News at a glance for May 1 to 7, 2023.

GPCR Activation and Signaling

• Constitutive activity of the dopamine (D5 ) receptor, highly expressed in CA1 hippocampal neurons, selectively reduces CaV 3.2 and CaV 3.3 currents.

• Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival.

• Cholesterol Biases the Conformational Landscape of the Chemokine Receptor CCR3: A MAS SSNMR-Filtered Molecular Dynamics Study.

• Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein-coupled receptor.

GPCR Binders, Drugs, and more

• Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.

GPCRs in Neuroscience

• GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders.

• G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.

GPCRs in Oncology and Immunology

• Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Ca2+ Flux.

Methods & Updates in GPCR Research

• Multiplexed selectivity screening of anti-GPCR antibodies.

Structural and Molecular Insights into GPCR Function

• Structural insight into an anti-BRIL Fab as a G-protein-coupled receptor crystallization chaperone.

• Molecular architecture of the Gαi-bound TRPC5 ion channel.

Industry News

• Addex Therapeutics to Release Q1 2023 Financial Results and Host Conference Call on May 11, 2023

• Neurocrine Biosciences Reports First Quarter 2023 Financial Results

• Find Therapeutics welcomes Dr. Jack Antel to its clinical advisory board

• Crinetics Pharmaceuticals First Quarter 2023 Earnings: Revenues Beat Expectations, EPS Lags

• “As Precision Medicine is critical, we cannot think about one size fits all” Dr Pina Cardarelli, Chief Scientific Officer, GPCR Therapeutics

• Trevena to Participate in Three Upcoming Conferences

GPCR Events, Meetings, and Webinars

• ASPET 2023 - American Society for Pharmacology and Experimental Therapeutics (May 18 - 21, 2023).

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• PEGS Boston (May 15 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• FREE Symposium - IPI Surfacing (June 15, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• Vice President, Medical Affairs

• Associate Scientist - Technology

• Senior Research Scientist/Principal Scientist- Technology

• Tissue Culture Scientist/Tissue Culture Manager

• Postdoctoral Researcher

• Director - Targeted Oncology

• Senior Scientist - Antibody Engineering

• Scientist—Immuno-Oncology

• Convergent Research - Senior Scientist, Cell-Based Assay Development

Explore Dr. GPCR Ecosystem