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I received my PhD in Biology at Arizona State University, where I worked in the lab of Miles Orchinik

schedule A positive Allosteric Modulator of M1 Acetylcholine Receptors Improves Cognitive Deficits in Male and Female Alzheimer’s Mice Date & Time Friday, November 3rd / 1:55 PM About Khaled Abdelrahman Dr.

Ceddia 1, *, Zack Zurawski 2,3,*, Analisa Thompson Gray 2, Feyisayo Adegboye 2, Ainsley McDonald-Boyer

Con mice, and developed normally. can concentrate urine as effectively as control mice. Anxiety and memory function were tested using both male and female mice at 5-6 month of age. compared to wildtype mice. The y-maze showed a significant sex by genotype interactions with GPR110 KO male mice having increased

Genetic Deletion of Atypical VGLUT3 Rescues Huntington’s Disease Phenotype and Neurodegeneration in zQ175 Mice

Mike then joined the lab of Dr. Muthuswamy moved to the University of Toronto, Mike joined the laboratory of Dr. Mike's Research on Cell Polarity and GPCRs in Cancer Mike shared his research on cell polarity and its Career Trajectory and Faculty Position Yamina and Mike discussed Mike's career trajectory and his decision Towards the end, Yamina asked about job opportunities in Mike's lab, to which Mike responded that potential

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Mike Caterina laid the foundation. But the deeper mission? The lab’s work with RGS4 led to unexpected results: knockout mice spontaneously recovered from chronic From struggling to grip mice in early animal studies to thesis delays during COVID-19, Serafini's journey

our understanding of the role of GPR110 signaling in kidney, we evaluated the urine albumin level in mice renal phenotype, we analyzed in parallel differential expression of kidney proteins in GPR110 KO and WT mice the albumin to creatinine ratio was significantly elevated in urine samples obtained from GPR110 KO mice proteins including VEGFA is associated with the abnormal renal phenotype of albumin urea in GPR110 KO mice

Our laboratory is working to help patients by developing genetically-modified mice that have disease-causing These mice can then be used to test dietary regimens, drugs, and adenoviral gene therapies for their

2005 by studying the suitability of nanoparticles as porters of DNA vaccination against allergens in mice hyperparathyroidism and their impact on body calcium homeostasis and bone resorption in relevant transgenic mice

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The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice

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learn more about how Kari studies GPCRs in basal ganglia circuits following chronic alcohol exposure in mice

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels

vivo (measures of physiological and pathological cardiometabolic function in unconscious and conscious mice

germline Tp53 deletion) with a second floxed allele under the control of Nestin-Cre was crossed to Bai3-/- mice Immunoblots on wild-type and Adgrb1 exon 2-deleted mice, reverse transcription PCR and promoter-luciferase We performed single-nucleus RNA sequencing on male and female kidneys. snRNAseq revealed abundant, cell-specific Restoration of ADGRB1 expression slowed tumor growth and improved survival in mice bearing MB xenografts

Michael Lemieux ''My name is Michael (Mike) Lemieux and I am a Connecticut native.

Metabolism 2023), recognition of amine containing hormones by GPCRs (Cell 2021, 2023, Nature 2023b), bile

intratumoral administration of the ADC in patient-derived GBM xenografts in the brain of immunodeficient mice resulted in significant reduction of tumor growth and prolongation of survival of host mice.

the optimization of longitudinal intravenous self-administration paradigms for genetically modified mice

the optimization of longitudinal intravenous self-administration paradigms for genetically modified mice