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Back to podcast list Strategic Partner(s) Michel Bouvier: BRET, Biased Agonism, and the Tools That Changed and the path toward receptor pharmacology 08:18 Cold-calling Bob Lefkowitz - landing the postdoc that changed

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structural work on the GPCR-G protein complexes have also revealed some unprecedented conformational changes Some of these changes are associated with G protein activation while the functional consequences of other structural changes remain elusive. have been heavily engaged in studies to address the functional role of these dramatic conformational changes

Conformational change is Schulte's strongest argument for GPCR identity Using cpGFP-based conformational frizzled receptors, Schulte's lab has shown that Wnt stimulation produces detectable conformational changes beta-arrestin and disheveled fit in Wnt signaling 47:01 The class F CRISPR knockout cell line that changed everything 53:43 Conformational change as the strongest argument for GPCR identity 01:03:11 Career advice "We clearly see that Wnt stimulation changes the conformation of the frizzles that we have looked at

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In alcohol use disorder and other substance addictions, one of the most consequential changes is the circuit-selective mouse models to ask which specific corticostriatal pathways are driving behavioral change Modulomics: Naming the Question Changes What You Can Ask Johnson's postdoc mentor Dave Lovinger coined The Habit Framework Changes What Addiction Means Pharmacologically The shift from goal-directed to habitual Goal-directed behavior is sensitive to changes in outcome value; habitual behavior is not.

“That’s the moment that changed my entire career. I was trusted to build a team from scratch.” “I changed from being an extreme introvert to someone who thrives on connection.” His story underscores how something as simple as forwarding a resume or reaching out for coffee can change

Ph.D. from Weill Cornell Graduate School of Medical Sciences in New York City, studying epigenetic changes

From Researcher to Scientific Leader Maria’s story is one of trusting her instincts while embracing change chemist in Italy, but a postdoc opportunity in Santiago de Compostela—and a mentor’s timely suggestion—changed That changed with support from Galicia’s robust biotech network, and the company quickly defined its

Scientific Themes of the Conversation Real-time vs. endpoint assays - why kinetics change the pharmacological That has changed. They're interacting with the cytoskeleton, with other proteins, with other receptors, and that will change That will change their ability to bind."

Since then, Brendan worked as a research assistant at the Victor Chang Cardiac Research Institute where

the most overlooked GPCRs in pharmacology - and Masha Niv has spent her career building the tools to change A single atomic change in water is enough to activate the sweet taste receptor Deuterated water - in What makes this finding unusual is the magnitude of the effect relative to the size of the chemical change "It's such a small change and you get this effect.

Finding the Right Mentor and Lab A birthday email changed everything. But once released, it changed everything. membranes, ligands.” – Alessandro Nicoli He emphasized that MD allows researchers to observe allosteric changes

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Lastly, they touched upon the global challenges of healthcare workforce growth, climate change, and emerging Lastly, they discussed the global challenges of healthcare workforce growth, climate change, and emerging The conversation highlighted ongoing challenges within universities, including resistance to change and

Lastly, they touched upon the global challenges of healthcare workforce growth, climate change, and emerging Lastly, they discussed the global challenges of healthcare workforce growth, climate change, and emerging The conversation highlighted ongoing challenges within universities, including resistance to change and

framework that dominates oncology and suggests GPCRs may contribute to pathophysiology through expression changes The "unknown unknowns" should change how we fund and train scientists Dr. Advice for young scientists: think broadly, resist narrowing too fast 42:14 Aha moments — the data that changed

This conversation covers how thermostabilization changed what was structurally possible, how cryoEM then to GPCRs - produced a light-bulb recognition that reshaped his entire research direction. 21 degrees changed GPCRs - instability as the bottleneck nobody was solving 17:00 The Friday afternoon library paper that changed

Giros' lab investigates how molecular changes at the nerve synapse might impact integrated behavior and

conventions of proteins in the field, with Yamina expressing concern about the potential confusion caused by changes the question of what advice Demet would give his younger self, but Demet responded that he wouldn't change

occupancy, staggering, communication 06:50 The productivity paradox — "it's like heaven" 07:55 What will change highlights how his past experience proves useful in current COVID times and potential benefits the changes

distribution in islets and brain circuits shapes incretin hormone drug effects Why visualization tools changed

In 2010 he became a group leader at the Paul Scherrer Institute and ETH Zürich in Switzerland, changing

Virtual docking changes the scale equation Individual bench approaches to identifying tool compounds guardrail Knowing what an EC50 means experimentally, or what a Bmax implies about receptor expression, changes

phase and decision points Map go/no-go logic that guides program momentum Focus resources where they’ll change

. 👉 Decision-making changes. Plans that once felt flexible start to feel constrained.

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