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10 items found for "Rosie Dawaliby"

Posts (3)

  • Dr. Rosie Dawaliby Podcast!

    Rosie Dawaliby! Watch the full video with a Dr. GPCR Ecosystem paid membership ➡️ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-84-with-rosie-dawaliby

  • Dr. Ross Bathgate becomes Scientific co-founder of LASEREDD Therapeutics

    I’m happy to share that I’m starting a new position as Scientific co-founder LASEREDD Therapeutics" Ross

  • Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR

    β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs typically interact with phosphorylated C-terminal tail (C tail) and transmembrane core (TM core) of GPCRs. However, the effects of the C tail- and TM core-mediated interactions on the conformational activation of βarrs have remained elusive. Here, we show the conformational changes for βarr activation upon the C tail- and TM core-mediated interactions with a prototypical GPCR by nuclear magnetic resonance (NMR) spectroscopy. Our NMR analyses demonstrated that while the C tail-mediated interaction alone induces partial activation, in which βarr exists in equilibrium between basal and activated conformations, the TM core- and the C tail-mediated interactions together completely shift the equilibrium toward the activated conformation. The conformation-selective antibody, Fab30, promotes partially activated βarr into the activated-like conformation. This plasticity of βarr conformation in complex with GPCRs engaged in different binding modes may explain the multifunctionality of βarrs. Read full article

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  • Ep 84 with Rosie Dawaliby

    Rosie Dawaliby About Dr. Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially Rosie Dawaliby on the web LinkedIn Dr.

  • Ep 84 with Rosie Dawaliby

    Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially Rosie Dawaliby on the web LinkedIn Dr.

  • 22-08 Dr GPCR Newsletter

    Andrew Tobin, Bryan Roth , Rosie Dawaliby , Steve Ferguson , Karen Gregory , Oliver Hartley , Juan Jose Rosie Dawaliby from G.CLIPS biotech . Our next guests include Dr. Nicholas Holliday , Dr.

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