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Jens Carlsson shares how GPCR modeling is moving from explanation to real prediction in drug discovery Yamina Berchiche to share his unconventional journey from aspiring engineer to GPCR modeler. From virtual screening of billions of molecules to leveraging AlphaFold for structure prediction, Jens shares his team uses structure-based modeling to identify novel GPCR ligands The value of failure—and how it shaped Why collaborations between modelers and experimentalists are more vital than ever How AlphaFold is shaking

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The Power of Asking the Right Question – Dmitry emphasizes that mastering a technique isn’t enough—true scientific breakthroughs come from formulating the right biological questions.

Kenakin's weekly insights and AMAs — building shared language around GPCR data and pharmacological decisions Find the right service provider for your assay, screening, or discovery needs — without wading through Find the right collaboration model for your program.

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: Building a Lab That Doesn't Shut Down Conversations that happen when a research community faces a shared That dual lineage — extramural academic and intramural NIH — shapes how he thinks about research infrastructure A small language correction with structural weight. Dr. pandemic, not further apart — the physical space contracted, but the community expanded through Zoom, shared The discipline is not in being right, but in being willing to let go of the framework you built when

Waldhoer argues that most of what distinguishes one compound from another lives in the shape of the kinetics The "artificial system" critique misses what those systems do for people who know how to ask the right :53 — "You're only as good as the other people you're with" Selected Quotes "A long way through the bright

If the right ligand could engage G-protein signaling while sparing β-arrestin, pain relief might finally physician-turned-pharmacologist whose early project in Michel Bouvier's lab felt like "torture" until the right It has been a refusal to treat messy data as noise until the right math arrived to make sense of it.

clinical focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right

Share your thoughts and help shape the future of the Dr. GPCR Ecosystem. ’ve joined our University sessions, explored our Job Board, or attended a Happy Hour, your feedback shapes We’re growing — and your input helps us grow in the right direction. By sharing your thoughts, you directly influence how we design new features, events, and educational Your Voice Shapes Our Future Dr.

molecular mechanism through which rare genetic variation may lead to or protecting from excessive body weight In future talks and interviews, Jacek will share his stories and advice about GPCRs. They talked about their shared passion for advancing science and improving patient outcomes, and their Jacek shared his experience of working with Piketa and how he found a job in Seda's lab at Cambridge, , and their roles in regulating body weight and growth.

Find the right plan for your team — from small groups to institution-wide access. Premium resources, your member dashboard, and exclusive community tools to start networking and learning right

more prone to activation, and resistant to pharmacological blockade - and why those properties have shaped The drug bitterness blind spot persisted for decades because no one built the right tool early enough bitter taste GPCRs in the lung or intestine, contributing to effects that were never attributed to the right 08:03 - Choosing taste GPCRs as a research focus - how the arrival of GPCR structures made this the right

research asks how the regulatory proteins that most GPCR pharmacologists have not yet addressed actually shape examining how the GLP-1 receptor engages its transducer partners and how G protein regulatory proteins shape The insight that G protein regulatory proteins may shape the functional selectivity of GLP-1 agonists Receptor as a Window Into Neurodegeneration Beyond its established roles in glucose homeostasis and body weight formulated in a more siloed setting - and access to expertise she could find simply by walking to the right

draft to the cloning of the beta-2 adrenergic receptor — and reflects on what it takes to choose the right adrenergic system, with its rich pharmacological toolkit and cardiovascular relevance, made it the right High output vs. low output failure: choosing the right scientific problem — The framework Lefkowitz articulates It was the moment they understood that all GPCRs would share this architecture. 5. Sharing the Nobel with a trainee he never interviewed When Dr.

Actionable Scientific Validation: Ensure target companies execute the right GPCR pharmacology experiments GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr.

Eric Trinquet shares the inside story behind the development of pH Sense, Revvity’s latest innovation and product development, Eric takes us through the highs, failures, and scientific “aha” moments that shaped Episode How Eric and his team reimagined rare earth complexes to develop pH-sensitive probes with tunable brightness

presents intriguing scientific questions. 45:00 — Scientific turning points Three key “aha moments” that shaped All right, I always ask this question from everyone who comes on the podcast. Joseph Kim: Right—and once you start thinking about allosteric modulation, you open an entirely new set Looking back at your career so far, what would you say are the three biggest “aha moments” that shaped my close friends at the time noticed how quickly I pivoted once I realized that medicine wasn’t the right

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