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facilitates cryo-EM structure determination of a Family A GPCR Jun Xu , Geng Chen , Haoqing Wang , Sheng Cao , Jie Heng , Xavier Deupi , Yang Du , Brian K Kobilka Red and far-red cleavable fluorescent dyes

chemokine antagonist ([5P7]CCL5), and a small-molecule inverse agonist (maraviroc) (Tan, Zhu et al. 2013, Zheng CCL15L (residues 26-92) and CCL15M (residues 27-92), while the third structure lacks a ligand (Shao, Shen conformational change of Y2917.43 tilted toward TM2, a model supported by mutagenesis experiments (Shao, Shen

Yongfeng Liu ,  Marion Lanier ,   Brian K Shoichet ,  Esther Martinborough ,  Jonathan F Fay ,  Can Cao

their investigation on Molecular insights into G protein coupling specificity at a class A GPCR Jianjun Cao

Norton Cheng and Dr.

Dysfunction of the adhesion GPCR latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity Norton Cheng

Ki values were then calculated using the Cheng–Prusoff equation, with CELT-331 parameters fully reported

Schlander M, Hernandez-Villafuerte K, Cheng CY, Mestre-Ferrandiz J, Baumann M. Shen S, Zhao C, Wu C, Sun S, Li Z, Yan W, et al.

determined to be 30.1 ± 1.7 nM corresponding to apparent Ki ± SEM = 15.7 ± 0.9 nM according to the Cheng-Prusoff

the fully integrated PROcisionXᵀᴹ discovery platform Structure-based validation of Orion’s approach Zheng