Ben Clements The Power of Inclusion in the GPCR Field This episode kicks off with a celebration of early-career scientists. the importance of diverse voices in the GPCR community: “It’s been a very difficult path to get more early-career scientists on the podcast. Advice for Junior Scientists: Read, Rest, Run Ben closes with wisdom for early-career researchers: “Academia

From her early doubts to designing preclinical models of fentanyl and xylazine overdose, she reflects Who Should Listen This episode is especially relevant for: GPCR drug discovery scientists Respiratory pharmacologists Addiction researchers Public health professionals Early-career scientists navigating Catherine Demery on the web LinkedIn Google Scholar University of Michigan 🎧 Listen now and see how one scientist Leave a quick review to help more scientists find the show—and help us keep improving every episode.

community at the early-career stage KEY INSIGHTS FROM THE CONVERSATION The probe gap is a biological Connecting scientists is its own form of science Bender's role co-chairing the Gordon Research Seminar He articulates that the lateral connections formed at early-career conferences, between people who will agonists 52:54 Bench fluency as a guard against over-interpreting computational models 58:16 Advice for early-career scientists on connecting with the field 01:02:48 Eureka moment - patterns across the whole receptor

operational models of agonism to allosteric binding equations, was designed to be applied by bench scientists Early-Career Researchers Know More Than They Think Hoare makes an argument that surprised him when he artifacts to expect, what the literature actually shows — that depth of expertise is marketable, and most early-career scientists don't recognize that they have it. Leave a quick review to help more scientists find the show—and help us keep improving every episode.

A famous scientist at Stanford and an NIH program officer both told Dr. at Case Western to leading a thirty-person GPCR lab at UNC is worth sitting with — particularly for early-career scientists who feel the same verdict closing in. Studying functional selectivity for the Navy in 1987 22:50 "You're never going to make it as a basic scientist Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Scientific Themes of the Conversation Olfactory receptors as general-purpose chemosensors outside the Pluznick's advice to early-career scientists is shaped by her own near-dismissal of an inconvenient microarray generated using AI for readability. 00:00 Opening: newsletter, season close, and welcome 02:13 Becoming a scientist Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific Leave a quick review to help more scientists find the show—and help us keep improving every episode.

full-length structures in multiple states still need to deliver for drug design 25:01 - Advice for early-career scientists: the role of passion in sustained scientific work 26:15 - Three "aha" moments that shaped a career - from MHC antigen presentation to the cryo-EM revolution 29:55 - Increasing diversity in science "I would advise young scientists to follow their interests and to work on projects that they're passionate Leave a quick review to help more scientists find the show—and help us keep improving every episode.

scientists and recruits for biotech and life sciences companies. She trained as a scientist and spent her first decade in preclinical and early clinical drug discovery Scientific Themes of the Conversation The gap between scientific training and the career vocabulary scientists Scientists navigating a career change are better served mapping careers by tasks and functions first, Post-pandemic career decisions are about alignment, not just advancement Solano observes that many scientists

Sokhom Pin shares how he built a biotech career around GPCRs, designed a custom PhD path, and led teams From his early work as a technician at Johns Hopkins Hospital to leading biology at Servo Therapeutics From Scientist to Leader At Alkermes, Sokhom took his first leadership role and finally experienced the For any scientist navigating career uncertainty—his story is both roadmap and inspiration. Leave a quick review to help more scientists find the show—and help us keep improving every episode.

This episode is for scientists who want to understand what early drug discovery actually costs - and , and the scientist who refuses the mold Key Insights from the Conversation Early discovery is the most Scientists who build careers in this space often generate more foundational knowledge than their publication For scientists trained to distrust that instinct, it is a useful challenge. I feel like as scientists, we should be who we are.

Jacek Mokrosiński "Jacek is a Senior Scientist at Novo Nordisk specializing in molecular pharmacology They talked about their shared passion for advancing science and improving patient outcomes, and their early Jacek's Career Journey and Advice Jacek and Yamina discussed Jacek's career journey, focusing on his turn, talked about her work on melanocortin receptors and an upcoming collaboration with a postdoc scientist Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Scientific lineages and the transmission of scientific taste — How the values that make a scientist effective Lefkowitz committed to receptor research in the early 1970s, prominent pharmacologists, including Raymond Lefkowitz describes a senior scientist at the NIH who told him early in his career that the difference between an average scientist and a world-class one is the failure rate: 1% success versus 2%. careers.

at NIAID, and a senior scientist role at Generate Biomedicines, where she worked on class B peptide The bench scientist's perspective — which she explicitly values — comes at the cost of the field-level About this episode GPCRs have played a central role in my scientific career ever since I took Dr. Michel Bouvier’s class as an undergraduate student at the University of Montreal in early 2000. Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Mid-career, he has worked in finance and developed high-frequency trading systems. built cell imaging software and lab robots to accelerate cancer research and automated Thermo Fisher Scientific Following this, he joined an early-stage medical device start-up and in 5 years was responsible for project He then returned to information engineering and has been working in machine learning for nearly 10 years Leave a quick review to help more scientists find the show—and help us keep improving every episode.

The broader argument Arey has spent his career developing is that biased signaling is not a GPCR-specific a book, co-authored with Terry Kenakin, that Arey dedicated to his children - not because they are scientists His early work at Wyeth's Women's Health Research Institute produced foundational observations on biased Martin Rodbell - drawing the FSH data on a napkin and hearing "I'm not surprised" 53:07 Advice for scientists Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Later in his career, Dr. Scientific Careers Depend on Teams, Mentors, and Community . For younger scientists, his advice centers on doing work you genuinely enjoy, finding supervisors who target discovery from association studies, and reflections on why many signals remained elusive. 52:00 — Career Leave a quick review to help more scientists find the show—and help us keep improving every episode.

personal loss in New York and leading a cancer center building that operated at 93% capacity during the early He had to decide, week by week, what could pause and what couldn't, and whose careers would bear the Gutkind describes operating his cancer research building at 93–94% capacity during the early pandemic Computational scientists suddenly had uninterrupted time at home with full data access and far fewer Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Advance your GPCR research career with Dr. GPCR University. Access 20+ on-demand GPCR courses, 200+ expert talks, weekly news, and a global scientist network. at every career stage who want to stay sharp, connected, and supported. 🎓 Early-career researchers You're in the room with the scientist, asking your question — not watching from the audience. "Will this really help my career?" Yes.

Marro’s career spans big pharma and biotech, encompassing functional assay development, GPCR internalization Scientists seeking practical advice on career pivots between academia, pharma, and biotech. Marro’s career advanced through roles at Novartis and Tectonic Therapeutic, contributing to projects With over two decades in drug discovery, he has established expertise in early phase functional assay Leave a quick review to help more scientists find the show—and help us keep improving every episode.

why δ-opioid receptors recycle from the lysosome, and the quantitative pharmacology that turned an early Early in her postdoc, Dr. Follow the questions, not the career. Asked what advice she gives young scientists, Dr. "I do not think I have a career. Leave a quick review to help more scientists find the show—and help us keep improving every episode.

recounted Badr's Journey, Multiplexing Assays, and Collaboration Badr shared his learning process and early Lastly, they concurred on the collaborative nature of the scientific community, where scientists build lab manager to facilitate communication within their global scientific team and ensure scientists could They identified the challenges scientists, particularly students and researchers, face, such as imposter Leave a quick review to help more scientists find the show—and help us keep improving every episode.

AI and machine learning are opening new doors—but only if scientists know their tools’ limits. ever How AlphaFold is shaking up structural biology—and where it still falls short Advice for junior scientists : what really matters when building a research career Who Should Listen GPCR scientists and pharmacologists Computational chemists and structural biologists Early-career researchers exploring drug discovery Biotech Leave a quick review to help more scientists find the show—and help us keep improving every episode.

That gap in care sparked a curiosity that became a career. His early exposure to TRPV1 channels and peripheral pain mechanisms with Dr. He joined Mount Sinai through FlexMed — bypassing the MCAT — and was torn between a career in pharma He aspires to become a physician-scientist, with a focus on translational in vitro and in vivo model Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Scientific Careers Often Evolve Unexpectedly Dr. I’m currently a senior scientist at a biotech in Toronto, Canada. Vaidehi, I don’t remember ever having female computational scientists on the podcast. I was wondering if you could speak to your experience being a computational scientist. ” in your career.

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Given her expertise in GPCR pharmacology and scientific communication, she is poised to make valuable Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Insel also directs UCSD's MD-PhD Medical Scientist Training Program, a role he has held for over 30 years Insel was the only unmarried scientist at a dinner with Al Gilman. The "unknown unknowns" should change how we fund and train scientists Dr. caution 35:00 The case against reductionism — why native cell biology matters 38:05 Advice for young scientists Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Chuck DeWeese, controller at CLP, joined the mission after pivoting from a sales career into accounting complex financial data and a scientist getting a long-awaited result. He compares entrepreneurship to a scientist’s journey: uncertainty, trial-and-error, and the necessity This realization forms a deep connection between accountants and scientists alike. Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Spot Taste receptors are among the most overlooked GPCRs in pharmacology - and Masha Niv has spent her career Niv's early exposure to bitterness as a formulation problem rooted her work in a question that still GPCR announcements 01:26 - Niv's career path - from theoretical chemistry in Russia and Israel to biotech bitterness in nutrition - the case for accepting bitter compounds in Western diet 50:13 - Advice for junior scientists Leave a quick review to help more scientists find the show—and help us keep improving every episode.

The breadth of a scientific career is sometimes a temperament, not a strategy Hauser traces his integrative 04 - Joining David Gloriam's group and first encounter with GPCRs 17:14 - What a computational GPCR scientist translational challenge - convincing clinicians to act on pharmacogenomics findings 50:02 - Advice to junior scientists "It's important to have clinicians on board very early on. Leave a quick review to help more scientists find the show—and help us keep improving every episode.

opioid story suggested The neat bifurcation between G-protein and beta-arrestin signaling that drove early Shukla wasn't sure research would be his career. For many scientists, the origin moment is this ordinary and this decisive. "I was not, to be honest, sure if research was what I wanted to take up as a career. Leave a quick review to help more scientists find the show—and help us keep improving every episode.