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. << Back to podcast list Strategic Partner(s) How Lipid Rafts Organize GPCR Signaling This episode features database and reviews key findings from his research on D1 receptor desensitization and GRK isoform signaling Why This Matters How lipid raft microdomains selectively regulate GPCR signaling and internalization protein-coupled receptors and D1 receptor regulation—work that sparked his ongoing engagement with receptor signaling

GPCRs Do Not Produce a Single Signal Dr. Activation of a receptor can generate multiple signaling pathways, and different ligands can bias signaling Absence of a Signal Can Be a Discovery One of Dr. “People think a receptor produces one signal. In reality, a receptor produces many signals.” But GPCRs activate multiple signaling pathways simultaneously.

Explore GPCR signaling kinetics and temporal drug action mechanisms with Sam Hoare. . < Back How Signaling Kinetics Shapes GPCR Drug Action May 14, 2026 10 AM - 11:30 AM EST 🔒 Watch Recordings Introduction GPCR signaling kinetics, the temporal dynamics of receptor activation and downstream signaling session addresses the clinical landscape of kinetic-dependent drug action, biosensor-based measurement of signaling Pharmechanics LLC, specializing in kinetic analysis of drug action and the application of binding and signaling

The Practical Assessment of Signaling Bias Dr. Terry Kenakin < Back Workshop Summary Join Dr. Terry Kenakin , a leading expert in pharmacology, as he unpacks the fascinating world of signaling bias how different ligands (compounds) can stabilize unique receptor conformations, leading to distinct signaling Key Highlights 🔍 Bias is Everywhere : Signaling bias naturally occurs in pharmacology—whether we look This allows for a side-by-side comparison of how different compounds influence receptor signaling. 📌

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights . << Back to podcast list Strategic Partner(s) Leadership, Impact, and GPCR Signaling with Dr. Michelle Halls shares how dissecting the spatial organization of GPCR signaling opens new doors in drug From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar localized signaling events, how these mechanisms are hijacked in disease, and how they can be leveraged

receptors (GPCRs) transmit extracellular signals through conformational changes that propagate from ligand-binding sites to intracellular signaling partners. Understanding how ligand binding leads to specific signaling outcomes—particularly ligand bias toward Nivedha describes how allosteric signaling within receptors can be quantified at atomic resolution. Allosteric Communication Explains Signal Propagation Ligand binding does not directly trigger signaling

John Streicher: Reorganizing Opioid Signaling Beyond the Receptor The dominant strategy for improving He came to this field because a signaling cascade felt like a puzzle he could not stop thinking about Streicher trained in signal transduction during his PhD on heart failure and p38 MAP kinase, and moved , not molecular identity HSP90 as a region-specific signaling scaffold — opposite roles in brain and It turns out that it was signal transduction, and he worked on the signaling cascades involved in heart

Discover how GPR65 reshapes our understanding of GPCR signaling and its role in cancer, with Dr. GPCR podcast. << Back to podcast list Strategic Partner(s) Signals, pH, and Discovery : Cracking GPCR This dual functionality—environmental sensing and compartment-specific signaling—offers a new layer of reflects on the value of a supportive lab culture , the need for better experimental tools in GPCR signaling My research has looked at the trafficking and signaling of adrenergic and proton-sensing receptors, with

Jennifer Pluznick: Olfactory Receptors in the Kidney and the Gut-Microbe Signal Olfactory receptors are Gut microbes at the other end of the signal. Matsunami's RTP1S chaperone, the Rho tag, and the Pluznick lab's Lucy tag — a cleavable leucine-rich signal

<< Back to podcast list Strategic Partner(s) Developing new tools to uncover GPCR signaling patterns works on diverse models and diseases, and has developed a wide array of tools to dissect GPCR/G protein signaling

Explore how subcellular location and temporal dynamics revolutionize GPCR signaling through nanodomains Introduction Classical GPCR signaling models assumed uniform receptor distribution and immediate signal Contemporary research reveals that subcellular location and temporal dynamics fundamentally determine signaling This session examines how receptor nanodomains, endosomal signaling compartments, and biomolecular condensates create distinct signaling environments that prevent crosstalk and enable pathway specificity.

Paul Insel turned dry-lab science into a reframing of COVID-19 pathobiology as a GPCR signaling imbalance Paul Insel: Rethinking COVID-19 Pathobiology Through GPCR Signaling In the spring and summer of 2020, What came next was a series of papers reframing severe COVID-19 as a disease of signaling imbalance: His research career has centered on GPCR signaling — with particularly deep work on beta-adrenergic receptors Severe COVID-19 may be a story of signaling imbalance, not just viral damage.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

Angers is an expert in the field of signal transduction. Moon , where he identified and characterized novel components of the Wnt signaling pathway and a new He is the recipient of the Canada Research Chair in Functional Architecture of Signal Transduction. His research program is developed to understand the signaling mechanisms underlying the Wnt and Hedgehog families of growth factors and their signaling mechanisms in development, adult tissue homeostasis,

in Jeff Benovic’s laboratory studying the regulation of G protein-coupled receptor trafficking and signaling Adriano’s research has contributed to our understanding of the role that ubiquitin plays in GPCR signaling His lab has shown a role for -arrestins and PTMs in GPCR trafficking and signaling and has leveraged this knowledge to reveal the spatial and temporal requirements for GPCR activation of signaling pathways The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic

a Professor in receptor pharmacology and research group leader for the section Receptor Biology and Signaling Australia, GPCR pharmacology; 2006) before starting his independent research team "Receptor Biology & Signalling General Research Interest: The focus in the Schulte lab is on Frizzled signaling and pharmacology aiming to understand the role of WNT/Frizzled signaling in biology, physiology, and disease. WNT-receptor interaction, the relevance of receptor dynamics, and receptor complex composition for signal

January 2021 and has contributed to multiple projects exploring the underlying mechanisms of biased signaling These previous endeavors involved exploring the effect of subcellular location on the signaling profile biased ligands, elucidating the role of site-specific receptor phosphorylation in the differential signaling She is currently working on her senior thesis which involves identifying the non-canonical signaling

Explore how GPCR signaling shapes mosquito feeding and mating behaviors with Dr. Laura Duvall. the molecular mechanisms that govern mosquito behavior, focusing on the intersection of neuropeptide signaling to inhibit pathogen transmission, highlighting unexpected links between mosquito and human gut-brain signaling How GPCR-mediated neuropeptide signaling dictates mosquito attraction to humans, directly impacting disease What functional and behavioral assays in mosquitoes reveal about the underlying diversity of GPCR signaling

He discusses biased signaling in GPCR research, developing biosensors for G protein activity, networking Highlights of the week Structural insights into prolactin-releasing peptide receptor signaling and G-protein drug discovery: Cell-based assays for GLP-1 and the G-Suite - Online March 17 - 21, 2025 | 2nd GPCR signaling and G-protein coupling selectivity Decoding the structural basis of ligand recognition and biased signaling in the motilin receptor 🔎 GPCR KEYWORDS GPCR , structural biology , biased signaling , metabolism ,

research program is to gain a thorough and mechanistic understanding of processes that control cell signaling The precise control of PAR signaling is critical for proper temporal and spatial dynamics of signaling Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and

Whether you’re decoding signaling pathways or designing the next generation of therapeutics, Revvity it doesn't emit a strong signal when bound to the surface. Internalization into acidic compartments = signal activation: Upon receptor-mediated endocytosis, the TRF detection, which effectively filters out short-lived background signals. pathway, from ligand binding and G-protein activation to intracellular signaling readouts.

Terry Hebert on why challenge trials weren't ready, what it takes to hold a GPCR signaling lab together The discussion moves across three scientific registers: the practical mechanics of holding a GPCR signaling His work is grounded in careful assay development and a conviction that the signaling space around a BRET platforms for GPCR signaling — The role of resonance-energy-transfer-based assays in capturing signaling Much of his work is based on GPCR signaling in the context to cardiovascular diseases.

Background and Localization Influence GPCR Function Scientific Abstract Most of what we know about GPCR signaling Hebert's research focuses on the angiotensin AT1 receptor, a signaling hub coupled to Gq, Gi, G12, and His research centers on GPCR signaling networks, biosensor development, and the role of cellular context His contributions span GPCR dimerization, nuclear receptor signaling, and the emerging role of G-proteins cells may not reflect what happens in native tissues, and how biosensors reveal cell-type-dependent signaling

My long-term research interests involve resolving signaling pathways downstream of aGPCRs and establishing how/if these receptors’ adhesive properties influence signaling events, and in turn, whether signaling

She identified the structural determinant controlling biased signaling of melatonin type 2 receptors which led to the finding that both β-arrestin and G protein can simultaneously bind to some GPCRs when signaling Funded by a Wellcome Trust Seed Award, she investigated biased and compartmentalized G protein signaling Her subsequent work has focused on understanding the role of compartmentalized Gq signaling by the cytomegalovirus-encoded

Terry Kenakin ’s hands-on workshop, The Practical Assessment of Signaling Bias . Didn’t sign up? Highlights of the Week How Ligands Achieve Biased Signaling toward Arrestins Stéphanie Gaillard , Neha obesity drug discovery: Cell-based assays for GLP-1 and the G-Suite March 17 - 21, 2025 | 2nd GPCR signaling Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing GPCR Activation and Signaling potentiates Kir7.1 to promote food consumption Reviews, GPCRs, and more How Ligands Achieve Biased Signaling

His research spans four decades of GPCR signaling, from cyclic AMP and adrenergic receptor biology to The tumor signals fibroblasts to raise GPR68 expression, and the low pH of the tumor microenvironment then activates that receptor, which signals back to promote cancer survival. Biased signaling is real but harder to exploit than expected GPR68 couples to both Gq and Gs, and the That accidental assignment launched a career in GPCR signaling that has now spanned over four decades