. << Back to podcast list Strategic Partner(s) How Lipid Rafts Organize GPCR Signaling Scientific Abstract Sedaghat discusses the compartmentalization of GPCR signaling in lipid rafts, including work linking to the classical paradigm of GPCR phosphorylation and desensitization - Compartmentalization of GPCR signaling Where a receptor sits shapes what it signals Lipid rafts can segregate signaling proteins from their There are exceptions in every step of GPCR signaling."

How a bell-shaped FSH dose-response curve led to one of the earliest demonstrations of biased GPCR signaling Bias at the FSH Receptor Biased signaling - the idea that a single receptor can preferentially activate at the FSH receptor, which were among the first experimental demonstrations that a GPCR could signal Arey treated it as a signal. His recently published book on signaling bias, Biased Signaling in Physiology, Pharmacology, and Therapeutics

Michelle Halls reveals how organized GPCR signaling drives assay innovation and new therapeutic insights . << Back to podcast list Strategic Partner(s) Leadership, Impact, and GPCR Signaling with Dr. Michelle Halls shares how dissecting the spatial organization of GPCR signaling opens new doors in drug From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar localized signaling events, how these mechanisms are hijacked in disease, and how they can be leveraged

John Streicher: Reorganizing Opioid Signaling Beyond the Receptor The dominant strategy for improving He came to this field because a signaling cascade felt like a puzzle he could not stop thinking about Streicher trained in signal transduction during his PhD on heart failure and p38 MAP kinase, and moved , not molecular identity HSP90 as a region-specific signaling scaffold — opposite roles in brain and It turns out that it was signal transduction, and he worked on the signaling cascades involved in heart

list Strategic Partner(s) Jennifer Pluznick: Olfactory Receptors in the Kidney and the Gut-Microbe Signal Gut microbes at the other end of the signal. Matsunami's RTP1S chaperone, the Rho tag, and the Pluznick lab's Lucy tag — a cleavable leucine-rich signal

changes that propagate from ligand-binding sites to intracellular signaling partners. Understanding how ligand binding leads to specific signaling outcomes—particularly ligand bias toward Nivedha describes how allosteric signaling within receptors can be quantified at atomic resolution. Allosteric Communication Explains Signal Propagation Ligand binding does not directly trigger signaling She uses molecular dynamics and network analysis to map signaling pathways through receptors.

GPCRs Do Not Produce a Single Signal Dr. Activation of a receptor can generate multiple signaling pathways, and different ligands can bias signaling Absence of a Signal Can Be a Discovery One of Dr. “People think a receptor produces one signal. In reality, a receptor produces many signals.” But GPCRs activate multiple signaling pathways simultaneously.

Paul Insel turned dry-lab science into a reframing of COVID-19 pathobiology as a GPCR signaling imbalance Back to podcast list Strategic Partner(s) Paul Insel: Rethinking COVID-19 Pathobiology Through GPCR Signaling What came next was a series of papers reframing severe COVID-19 as a disease of signaling imbalance: His research career has centered on GPCR signaling — with particularly deep work on beta-adrenergic receptors Severe COVID-19 may be a story of signaling imbalance, not just viral damage.

<< Back to podcast list Strategic Partner(s) Developing new tools to uncover GPCR signaling patterns works on diverse models and diseases, and has developed a wide array of tools to dissect GPCR/G protein signaling

Discover how GPR65 reshapes our understanding of GPCR signaling and its role in cancer, with Dr. GPCR podcast. << Back to podcast list Strategic Partner(s) Signals, pH, and Discovery : Cracking GPCR This dual functionality—environmental sensing and compartment-specific signaling—offers a new layer of reflects on the value of a supportive lab culture , the need for better experimental tools in GPCR signaling My research has looked at the trafficking and signaling of adrenergic and proton-sensing receptors, with

to podcast list Strategic Partner(s) Kathryn Livingston: Allosteric Opioid Modulators and Receptor Signaling Rather than measuring endpoint states, she learned to watch receptors move, internalize, and continue signaling Internalized receptors don't stop working The membrane-centric view of receptor pharmacology assumes signaling Von Zastrow's lab challenged this directly, demonstrating that GPCRs continue to generate signals after A readout that captures a downstream marker, a surrogate signal, or a population average can yield clean

Terry Kenakin on detecting, quantifying, and applying receptor signaling bias in GPCR drug discovery. into a practical decision-making tool in GPCR drug discovery Beyond Potency: What Ligand-Dependent Signaling Reveals About Drug Candidates G protein-coupled receptors can signal through multiple intracellular This phenomenon, receptor signaling bias or functional selectivity, is now recognized as a meaningful This webinar explains the biological basis of signaling bias, shows how to detect and quantify it using

. << Back to podcast list Strategic Partner(s) Elva Zhao: G Protein Regulation and Biased Signaling at Receptor The GLP-1 receptor is among the most clinically validated targets in metabolic disease - yet the signaling asks how the regulatory proteins that most GPCR pharmacologists have not yet addressed actually shape signaling Nigel Bennett on biased signaling at the PAR2 receptor, then with Profs. Why GLP-1 Drugs Still Produce Nausea - and What Biased Signaling Might Fix The GI side effects of GLP

GPCR Identity Question Frizzled receptors are a family of 10 cell surface proteins that mediate Wnt signaling He began his scientific career studying adenosine receptor signaling during a PhD with Bertil Fredholm This would mean the receptor itself determines whether a signal flows through disheveled or through a Several were — the signal Schulte had mapped was an off-target receptor effect, not the kinase pathway to understand the role of WNT/Frizzled signaling in biology, physiology, and disease.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

faculty position at Duke in Gastroenterology, where he remained until 2018 studying GPCRs and their signaling My research focus is on understanding how distinct cellular signaling pathways interact and are coordinated For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling , and characterizing the role of protein S-nitrosylation as a signaling post-translational modification signaling systems.

nanobody-GPCR ligand conjugates that rescue weak peptides, engineer receptor selectivity, and probe endosomal signaling How does receptor conformation shape the duration of downstream signaling? Conformation selectivity changes the duration of the signal PTH receptor exists in G-protein coupled and duration of signaling 40:25 Are GPCRs still a good drug target? "I don't think tight binding equals longer signaling is necessarily the whole story.

in Jeff Benovic’s laboratory studying the regulation of G protein-coupled receptor trafficking and signaling Adriano’s research has contributed to our understanding of the role that ubiquitin plays in GPCR signaling His lab has shown a role for -arrestins and PTMs in GPCR trafficking and signaling and has leveraged this knowledge to reveal the spatial and temporal requirements for GPCR activation of signaling pathways The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic

Angers is an expert in the field of signal transduction. Moon , where he identified and characterized novel components of the Wnt signaling pathway and a new He is the recipient of the Canada Research Chair in Functional Architecture of Signal Transduction. His research program is developed to understand the signaling mechanisms underlying the Wnt and Hedgehog families of growth factors and their signaling mechanisms in development, adult tissue homeostasis,

Whether you’re decoding signaling pathways or designing the next generation of therapeutics, Revvity it doesn't emit a strong signal when bound to the surface. Internalization into acidic compartments = signal activation: Upon receptor-mediated endocytosis, the TRF detection, which effectively filters out short-lived background signals. pathway, from ligand binding and G-protein activation to intracellular signaling readouts.

Terry Hebert on why challenge trials weren't ready, what it takes to hold a GPCR signaling lab together The discussion moves across three scientific registers: the practical mechanics of holding a GPCR signaling His work is grounded in careful assay development and a conviction that the signaling space around a BRET platforms for GPCR signaling — The role of resonance-energy-transfer-based assays in capturing signaling Much of his work is based on GPCR signaling in the context to cardiovascular diseases.

Background and Localization Influence GPCR Function Scientific Abstract Most of what we know about GPCR signaling Hebert's research focuses on the angiotensin AT1 receptor, a signaling hub coupled to Gq, Gi, G12, and His research centers on GPCR signaling networks, biosensor development, and the role of cellular context His contributions span GPCR dimerization, nuclear receptor signaling, and the emerging role of G-proteins cells may not reflect what happens in native tissues, and how biosensors reveal cell-type-dependent signaling

January 2021 and has contributed to multiple projects exploring the underlying mechanisms of biased signaling These previous endeavors involved exploring the effect of subcellular location on the signaling profile biased ligands, elucidating the role of site-specific receptor phosphorylation in the differential signaling She is currently working on her senior thesis which involves identifying the non-canonical signaling

research program is to gain a thorough and mechanistic understanding of processes that control cell signaling The precise control of PAR signaling is critical for proper temporal and spatial dynamics of signaling Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and

His research spans four decades of GPCR signaling, from cyclic AMP and adrenergic receptor biology to The tumor signals fibroblasts to raise GPR68 expression, and the low pH of the tumor microenvironment then activates that receptor, which signals back to promote cancer survival. Biased signaling is real but harder to exploit than expected GPR68 couples to both Gq and Gs, and the That accidental assignment launched a career in GPCR signaling that has now spanned over four decades

InterAx Biotech, where he specializes in the development of a technology platform deciphering cell signaling pathways combined with AI-based approaches to elucidate structure to signaling relationship. Gebhard Schertler, he developed methods for kinetic mathematical analysis of GPCR signaling. Biotech, shared about the company's development of a discovery platform for GPCRs and their focus on signaling about the intricacies of cell signaling and chemokine receptors.

Introduction Desensitization limits the duration and magnitude of GPCR signaling, and the machinery that Instructor Adriano Marchese's research examines how GPCR signaling is regulated by β-arrestin-dependent and β-arrestin-independent pathways, with the goal of identifying and targeting novel aspects of GPCR signaling brings this mechanistic view of receptor regulation to the question of how desensitization shapes GPCR signaling

proteins, and cytoskeletal components, and those interactions reshape conformation, ligand binding, and signaling developed BRET and NanoBRET-based live-cell platforms that capture protein-protein interactions and signaling His research centers on GPCR functional interactions, with a focus on arrestin signaling, receptor complex Bias Signaling Is a Kinetic Problem, Not Just a Pathway Problem Spider plots comparing signaling bias For Pfleger, the reach of the technology is not a source of pride as much as a signal that the field