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Watch Episode 170 Thinking Differently Pain research has long followed a familiar route: from molecule Why This Approach Matters In pain research, bottom-up approaches often fail to translate. It asks researchers to consider the entire ecosystem: from patient to molecule , not just the other way Alex Serafini makes the case for building pain research from the clinic down, not the bench up. _____ ___ Keyword Cloud: GPCR podcast , pain modeling , GPCR online course , translational research , neuroimmune

Watch Episode 170 What We’re Missing in Pain Research In GPCR drug discovery, receptors typically steal Signaling (RGS proteins)  might hold some of the most untapped therapeutic opportunities, particularly in pain Venetia Zachariou  introduced him to the power of RGS proteins — particularly RGS4  — in modulating pain models and hints that RGS proteins could modulate pain chronification itself . . ___________ Keyword Cloud: RGS4 , GPCR data platform , GPCR training program , pain research , opioid

From Patient to Researcher Alex wasn’t always planning to be a scientist. school, Serafini aims to follow the physician-scientist path: part-time clinical work, mostly lab-based research generation of pain researchers needs to start from lived experience, not just literature. ___________ ______ Keyword Cloud: GPCR research community , chronic pain , GPCR drug discovery , GPCR scientist network , pain neuroscience

Alex Serafini shares why pain research must start with real-world behavior and models before drilling pain research at Hopkins and later an MD-PhD at Mount Sinai. He points out that GPCRs—especially orphan and CNS-associated ones—are often downplayed in pain research Pivoting: Redefining the Pain Research Playbook Looking ahead, Serafini’s vision is bold: build a lab That top-down approach, though less common, could help pain research finally catch up with the complexity

published seminal papers where he used various approaches to describe the role of opioid receptors in pain Dr Gendron is co-director of the FRQS-funded Quebec Pain Research Network and the Editor-in-Chief in

At the end of 2023, I joined the research group of Dr. Nigel Bunnett at the NYU Pain Research Center as a postdoctoral researcher. and chronic pain. Next Steps Badr will continue focusing his research on GPCRs involved in pain and inflammation during , and how his PhD research on non-canonical GPCR roles laid the foundation for his postdoc work.