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Watch Episode 170 Thinking Differently Pain research has long followed a familiar route: from molecule Why This Approach Matters In pain research, bottom-up approaches often fail to translate. It asks researchers to consider the entire ecosystem: from patient to molecule , not just the other way Alex Serafini makes the case for building pain research from the clinic down, not the bench up. _____ ___ Keyword Cloud: GPCR podcast , pain modeling , GPCR online course , translational research , neuroimmune

Watch Episode 170 What We’re Missing in Pain Research In GPCR drug discovery, receptors typically steal Signaling (RGS proteins)  might hold some of the most untapped therapeutic opportunities, particularly in pain Venetia Zachariou  introduced him to the power of RGS proteins — particularly RGS4  — in modulating pain models and hints that RGS proteins could modulate pain chronification itself . . ___________ Keyword Cloud: RGS4 , GPCR data platform , GPCR training program , pain research , opioid

From Patient to Researcher Alex wasn’t always planning to be a scientist. school, Serafini aims to follow the physician-scientist path: part-time clinical work, mostly lab-based research generation of pain researchers needs to start from lived experience, not just literature. ___________ ______ Keyword Cloud: GPCR research community , chronic pain , GPCR drug discovery , GPCR scientist network , pain neuroscience

CXCR4 takes on a nuclear role in red blood cell maturation CXCL13/CXCR5 emerges as a high-potential pain target ST171, a biased 5‑HT1A agonist, delivers selective pain relief in preclinical models Dr.GPCR Blocking this chemokine axis reduces pain  hypersensitivity by dampening neuroinflammation and glial This novel agonist activates Gi/o selectively , avoiding β-arrestin and showing strong pain relief in Explore this week’s research, tools, and biotech insights in one place.

November 22, 2021 JUPITER, FL—Scientists at Scripps Research in Florida have created a collection of new pain-relieving compounds that, like morphine and other drugs, provide relief via activation of opioid

Company’s novel S1P1 receptor modulator being developed as a potential treatment for diabetic neuropathic pain

How Fluorescence Polarization Assays Work: Principles and Applications in GPCR Research FP assays work Ligands Looking ahead, fluorescence polarization technology is expected to expand its role in GPCR research

His work spans deep academic research, startup life, and the application of machine learning and pharmacology There, Ajay expanded his understanding of neurobiology and translational research models, further refining He emphasizes that building a startup is not simply a continuation of research — it requires a mindset Advice for Young Scientists For early-career researchers, Ajay’s journey offers a powerful blueprint. clarify career decisions and research priorities.

Watch Episode 166 Pain management is broken. And Benjamin Clements is on a mission to fix it. In fact, one of their recent neuroma pain studies showed a tenfold increase in methadone potency. Beyond Acute Pain: Into the Chronic Unknown Opioids work well for acute pain. Chronic pain? With collaborations across medicinal chemistry and neuropathic pain research, Ben is bridging molecule Start learning with our GPCR University today. _______________ Keyword Cloud: GPCR research community

That’s not a story about nostalgia — it’s a snapshot of how GPCR research was built, on technique at These painstaking manual workflows laid the foundation for what would become the evolution of GPCR research Every step felt like it could make or break the result, The pace and precision of GPCR research today What Changed After This : High-throughput capabilities meant researchers could map GPCR signaling more The Mindset Shift: From Technique to Strategy Michelle reflects on how early-career researchers once

activity biosensors Marta Lopez-Balastegui, Antonella Di Pizio, Jiafei Mao, Jana Selent, et al. for their research Join fellow scientists and researchers in person to stay updated with adhesion GPCR biology. and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia Methods & Updates in GPCR Research - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Research

Why Purpose Matters in Science For some researchers, science is a job. For others, it’s a calling. , Catherine reflects on how her identity as a scientist took shape, why she’s committed to academic research she belonged in research. That alignment between curiosity and urgency set her on the path toward doctoral research. Catherine’s story shows that when purpose drives research, science becomes more than a job—it becomes

Watch the trailer 👇 What you’ll gain Validate the model behind the data.   Who should listen Researchers navigating complex datasets, balancing innovation with assay rigor, or conversation is part of a three episode series produced in collaboration with our partners at Celtarys Research How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research You also gain access to member-only discounts, full GPCR University content, and an integrated view of

Drum rolls, we’ve got 15 GPCR research papers, updates, industry news events, and GPCR ads curated just in downstream pathway activation Chiara D Mancinelli, Joshua Levitz, David Eliezer, et al. for their research It is an opportunity to connect with like-minded scientists and researchers and gain valuable insights signaling reveals unexpected differences in downstream pathway activation Methods & Updates in GPCR Research NEW Senior Scientist, Cryo-Electron Microscopy Postdoctoral Research Associate Senior Scientist - Discovery

John Streicher talks about his work on terpenes found in cannabis as these may be a novel way to treat pain These compounds may be a novel way to treat pain without the negative side effects of cannabinoids or

a variety of potential clinical applications with a great interest in the treatment of neuropathic pain optimization, this series of compounds could represent potential clinically useful S1R ligands for pain

This makes it an ideal candidate for GPCR research, where accuracy in detecting subtle signaling changes Enhancing HTRF Assay Performance in GPCR Research Using Fluorescent Ligands GPCRs are involved in numerous By using donor-acceptor pairs with different emission spectra that don’t overlap, researchers can design Examples of HTRF donor/acceptor pairs Expanding Time-Resolved Fluorescence Applications in Drug Discovery technologies by providing high-performance fluorescent ligands designed specifically for pharmacological research

Some Nbs that have been use for GPCR research are: Nb80: This nanobody stabilized an active-state conformation

Embark on another exciting exploration of the unknown realms of GPCR research. Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic Senior Scientist, GPCR Pharmacology Research Scientist, Computational Chemistry Postdoc in GPCR mechanosensing   GPCR Activation and Signaling A gain transepithelial dendrite formation in human intestinal dendritic cells Methods & Updates in GPCR Research

Therapeutics Doses First Subjects In Phase 1 Clinical Trial Of CFTX-1554 For The Treatment Of Neuropathic Pain CFTX-1554 is being developed as a non-opioid approach to the treatment of neuropathic pain, a debilitating

receptor activity-modifying proteins Nicholas Kapolka , Geoffrey Taghon , and Daniel Isom  for their research protein-coupled receptor-mediated signaling of immunomodulation in tumor progression Methods & Updates in GPCR Research Clinical Pharmacology GPCR Jobs NEW Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research

GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud to welcome Celtarys Research to its partner ecosystem. Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology , CEO of Celtarys Research. About Celtarys Research Celtarys Research is a biotech company based in Spain that specializes in the

In a recent study on TAAR1, a GPCR linked to central nervous system disorders, researchers compared the

Our scientific team can guide you choose or design the right fluorescent ligand for your research.  

After all, a good tool makes a good assay, and a good assay improves research capacity. Chemistry Tools session was more industry focused than those before, and Maria shared the floor with researchers

Embark on another exciting exploration of the unknown realms of GPCR research. The 11th Adhesion GPCR Workshop 2024 was a successful event that brought together experts, researchers Biology - Tectonic Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Biologist Senior Scientist/Staff Scientist, Computational Chemistry GPCR Activation and Signaling A gain promotes transepithelial dendrite formation in human intestinal dendritic cells Methods & Updates in GPCR Research

ahead without noise or delays: Industry insights:  Structure-Based Drug Design Summit; AI-Powered GPCR Research unconventional path—from patient to scientist—exemplifies why personal mission matters in translational research Serafini’s early struggles with chronic pain sparked a career focused on innovating where pain management Redefine your playbook:  Why Serafini believes that pain research needs to start from clinical phenotype s Corner  digital pharmacology courses Priority access to insights from major conferences, emerging research

Eric Trinquet, Director of Research and Development at Revvity.   A GPCR Internalization Tool Designed for Real Research Needs Built on more than two decade A GPCR Internalization Tool Designed for Real Research Needs s of GPCR assay innovation , pHSense™  was developed to overcome GPCR  is a global nonprofit platform advancing GPCR research  through education, community, and platform Its GPCR research tools  support discovery teams and academic labs with precision reagents and validated

Introduction Cannabinoid receptors are GPCRs, and two main types exist, CB1R and CB2R. occurring Δ9-tetrahydrocannabinolderivatives to cannabinoid CB1 and CB2 receptors, Pharmacological Research

Summit 💲 Special Pricing on GPCR courses GPCR Forum Start a lively chat or request help with your research Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration Methods & Updates in GPCR Research