📰 GPCR Weekly News, February 13 to 19, 2023

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Below is your Classified GPCR News at a glance for February 13th to 19th, 2023.

GPCR Activation and Signaling

• Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth of murine enteroids.

• Anionic phospholipids control mechanisms of GPCR-G protein recognition.

• Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric effects on ligand binding.

• From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction.

• Octopamine and tyramine signalling in Aedes aegypti: Molecular characterization and insight into potential physiological roles.

• The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics.

GPCR Binders, Drugs, and more

• Novel targets for potential therapeutic use in Diabetes mellitus.

Reviews, GPCRs, and more

• Single nucleotide variations encoding missense mutations in G protein-coupled receptors may contribute to autism.

• Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release.

Structural and Molecular Insights into GPCR Function

• Quantitative analysis of sterol-modulated monomer-dimer equilibrium of the β1-adrenergic receptor by DEER spectroscopy.

Industry News

• Trevena Announces Publication of OLINVYK Respiratory Physiology Study In Anesthesiology

• Neurocrine Biosciences discovers new muscarinic M4 receptor antagonists

• Alexander S. Hauser on receiving 4.8 mill DKK from Carlsberg Foundation’s Semper Ardens: Accelerate programme.

• From the scientist’s view: a conversation with … Chris Tate

• AI is dreaming up drugs that no one has ever seen. Now we've got to see if they work.

• Artificial Intelligence for Drug Discovery

Call for GPCR Papers

• GPCRs: Signal Transduction. Deadline extended to March 31st, 2023.

GPCR Events, Meetings, and Webinars

• SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023).

• 2nd ERNEST Training School. (February 20 - March 3, 2023).

• WEBINAR Using integrative biophysical approaches to understand GPCR regulation by β-arrestins. (March 2, 2023)

• GEM2023. (March 14-17, 2023).

• SLAS 2023 B

• Building Biology in 3D Symposium. (April 20 - 21, 2023)

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

GPCR Jobs

• Computational drug design PhD student at the Department of Drug Design and Pharmacology

• Computational drug design postdoc at the Department of Drug Design and Pharmacology

• Software / database development PhD student at Department of Drug Design and Pharmacology

• Software / database development postdoc at the Department of Drug Design and Pharmacology

• Postdoc in Bioinformatics/Data Science at Department of Drug Design and Pharmacology

• Scientist/Senior Scientist (Research Software Engineer)

• Senior Scientist – Native Mass Spectrometry

• Speculative Applications (Protein Biochemistry)

• Speculative Applications (Mass Spectrometry)

• Speculative Applications (Chemistry)

• Post-Doctoral Research Assistant

• Research Fellow - School of Physics and Astronomy

• Postdoctoral Research Associate (Fixed Term)

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