📰 GPCR Weekly News, January 16 to 22, 2023

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Below is your Classified GPCR News at a glance for January 16th to January 22th, 2023.

GPCR Activation and Signaling

• Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility.

• Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling.

• Cannabinoid tolerance in S426A/S430A x beta-arrestin 2 knock-out double mutant mice.

• Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation.

• The cannabinoid receptor 1 antagonist AM6545 stimulates the Akt-mTOR axis and in vivo muscle protein synthesis in a dexamethasone-induced muscle atrophy model.

Methods & Updates in GPCR Research

• Mapping of structural arrangement of cells and collective calcium transients: an integrated framework combining live cell imaging using confocal microscopy and UMAP-assisted HDBSCAN-based approach.

• First metabolic profiling of 4-n-nonylphenol in human liver microsomes by integrated approaches to testing and assessment: Metabolites, pathways, and biological effects.

Reviews, GPCRs, and more

• Olfactory Receptors as an Emerging Chemical Sensing Scaffold.

Structural and Molecular Insights into GPCR Function

• The role of G protein conformation in receptor-G protein selectivity.

• Targeting in silico GPCR conformations with ultra-large library screening for hit discovery.

• Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1).

Industry News

• Addex Provides Corporate Update And Financial Guidance

• Structure Therapeutics Appoints Industry Leaders Eric Dobmeier and Joanne Waldstreicher to its Board of Directors

• GPCR Therapeutics launches multiple myeloma trial

• Salipro Biotech is attending the 3rd Advanced Therapy Showcase in Tokyo, Japan, organized by LINK-J

• Jounce takes the cash under amended deal with Gilead on anti-CCR8 antibody

• InterAx Biotech Announces the Appointment of Seasoned Pharmaceutical Executive, Dr. Christopher Prior, as CEO and Reports Recent Drug Discovery Highlights

Call for GPCR Papers

• GPCRs: Signal Transduction. Deadline February 12, 2023

• Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology. Deadline January 30, 2023.

GPCR Events, Meetings, and Webinars

• 2nd GPCR-Targeted Drug Discovery Summit, (February 21 - 23, 2023), Boston.

• SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023).

• 2nd ERNEST Training School. (February 20 - March 3, 2023).

• GEM2023. (March 14-17, 2023).

• SLAS 2023 Building Biology in 3D Symposium. (April 20 - 21, 2023)

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

GPCR Jobs

• Postdoctoral Fellow - Molecular Dynamics

• Postdoc in lipid regulation of GPCRs

• Postdoctoral positions, biophysics of transporters and GPCRs

• Chief of Staff

• Postdoctoral Fellow, Biochemical And Cellular Pharmacology

• Project Leader, Biology

Explore Dr. GPCR Ecosystem