📰 GPCR Weekly News, March 27 to April 4, 2023

Hello Readers👋,

This week in the GPCR news we have collected the most up-to-date news for you. Enjoy!

For more great content, subscribe to our Dr. GPCR News monthly newsletter. Also, please mark your calendar for the next Dr. GPCR Symposium on GPCR Activation and Signaling held on May 19th, 2023. The program is under construction but if you’d like to give a talk or present a poster, email us at Hello@DrGPCR.com

Below is your Classified GPCR News at a glance for March 27th to April 4th, 2023.

Adhesion GPCRs

• Optimized genetic code expansion technology for time-dependent induction of adhesion GPCR-ligand engagement.

• The adhesion G-protein-coupled receptor VLGR1/ADGRV1 controls autophagy.

GPCR Activation and Signaling

• Butyrate potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome activation via histone deacetylase inhibition.

• Negative allosteric modulation of the glucagon receptor by RAMP2.

• Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs).

• Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia.

• Cannabinoid Tolerance in S426A/S430A x β-Arrestin 2 Knockout Double-Mutant Mice.

• Gαi-derived peptide binds the µ-opioid receptor.

• Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process.

GPCR Binders, Drugs, and more

• Predicting allosteric sites using fast conformational sampling as guided by coarse-grained normal modes.

• Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth of murine enteroids.

GPCRs in Cardiology, Endocrinology, and Taste

• Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK/PKD-Sensitive Manner.

• Dietary compounds activate an insect gustatory receptor on enteroendocrine cells to elicit myosuppressin secretion.

GPCRs in Neuroscience

• Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory.

• Neuronal activity-induced, equilibrative nucleoside transporter-dependent, somatodendritic adenosine release revealed by a GRAB sensor.

GPCRs in Oncology and Immunology

• Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure.

Methods & Updates in GPCR Research

• Discovery and design of G protein-coupled receptor targeting antibodies.

• A Vaccinia-based system for directed evolution of GPCRs in mammalian cells.

• First complete genome sequence of lumpy skin disease virus directly from a clinical sample in South India.

Reviews, GPCRs, and more

• NMR applications to GPCR recognition by peptide ligands.

• Developmental and homeostatic signaling transmitted by the G-protein coupled receptor FPR2.

• Dopamine Receptor D1R and D3R and GRK4 Interaction in Hypertension.

• Therapeutic potential of opioid receptor heteromers in chronic pain and associated comorbidities.

• Investigating the potential of GalR2 as a drug target for neuropathic pain.

• The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors.

Structural and Molecular Insights into GPCR Function

• Predicted Three-Dimensional Structure of the GCR1 Putative GPCR in Arabidopsis thaliana and Its Binding to Abscisic Acid and Gibberellin A1.

• Structural insights into constitutive activity of 5-HT6 receptor.

Industry News

• Confo Therapeutics Enters into Collaboration Agreement with Daiichi Sankyo to Discover Novel Medicines for CNS Diseases

• Addex Reports Full Year 2022 Financial Results and Provides Corporate Update

• Sosei Heptares Announces the Publication of its Inaugural ESG Report, for the Financial Year ended 31 December 2022

• Addex Raises $5.0 Million in Equity Financing

• Testing the limits of SMILES-based de novo molecular generation with curriculum and deep reinforcement learning

• Structure Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Recent Highlights

• Salipro Biotech publishes research in Scientific Reports on structure-function studies for membrane proteins in collaboration with AstraZeneca

• Expansion of precision oncology pipeline announced by Exscientia

• Upcoming start-up ecosystem - leadXpro and InterAx part of Fujitsu CaaS

GPCR Events, Meetings, and Webinars

• SLAS 2023 Building Biology in 3D Symposium. (April 20 - 21, 2023)

• Swiss Biotech Day (April 24 - 25, 2023)

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• FREE Symposium - IPI Surfacing (June 15, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• NEW Convergent Research - Senior Scientist, Cell-Based Assay Development

• NEW Post Doctoral Fellow

• NEW Research associate in protein production

• NEW Vice President, Oncology Clinical Research

• NEW PostDoctoral Associate

• NEW PostDoctoral Position

• Team Lead protein production and profiling

• Pharmacologist

• Postdoctoral positions at UC San Diego

• Medical Director

• CADD and Informatics Head or Team Lead (depending on experience) with Structural Bioinformatics Expertise

Explore Dr. GPCR Ecosystem