📰 GPCR Weekly News, October 23 to 29, 2023

Hi there GPCR minds! Join us for a deep dive into the world of GPCRs.

If you're attending the GPCR Retreat, be sure to swing by our booth and snap a photo at our banner! Plus, don't forget to ask for your special treat. We're proud sponsors and can't wait to connect with all of you. See you there!

This week's highlight:

• Congratulations to the GPCR Therapeutics team for their publication on improving hematopoietic stem cell mobilization using Propranolol.

Save the dates:

• November 17: Join our final Dr. GPCR Symposium for the year on GPCRs in Immunology and Oncology! A panel of top experts will discuss in a roundtable starting at 10 AM EST. Find speaker details on the Live Talks page and mark your calendar HERE.

Get the inside scoop by subscribing to our monthly Dr. GPCR Newsletter, and watch our latest video featuring Dr. Kathleen Caron.

Check out the weekly Classified GPCR News from October 23rd to 29th, 2023.

GPCR Activation and Signaling

• The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells

• GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function

GPCR Binders, Drugs, and more

• GPC-100, a novel CXCR4 antagonist, improves in vivo hematopoietic cell mobilization when combined with propranolol

• Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like Receptor 1 Antagonists for the Treatment of Psoriasis

GPCRs in Cardiology, Endocrinology, and Taste

• Ageing influences detrusor contractions to prostaglandin, angiotensin, histamine and 5-HT (serotonin), independent to the Rho kinase and extracellular calcium pathways

• Versatile lactate signaling via HCAR1: a multifaceted GPCR involved in many biological processes

GPCRs in Neuroscience

• Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor

GPCRs in Oncology and Immunology

• Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies

Methods & Updates in GPCR Research

• ThermoBRET: A Ligand-Engagement Nanoscale Thermostability Assay Applied to GPCRs

Reviews, GPCRs, and more

• Illuminating the druggable genome: Pathways to progress

Industry News

• Anatole Klepatsky, Orion's COO, Shared Innovative Insights at LSBC Central European Life Science Investment Conference

• GPCR Therapeutics Announces Publication on Improving Hematopoietic Stem Cell Mobilization Using Propranolol with GPC-100

• Sosei Heptares to Host R&D Day Highlighting its Innovative R&D and Late-Stage Development Progress

• Parker Moss to Join Exscientia as EVP, Corporate Development

• Confo Therapeutics Nominated for 'Deal of the Year (>€500 Million)' Award at European Lifestars Awards

GPCR Events, Meetings, and Webinars

• November 2 - 4, 2023 | GPCR Retreat- Registration Closed

• November 10, 2023 | Sosei Heptares Zoom Webinar

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

GPCR Jobs

• NEW Staff Scientist (AC-TAP) in Database Development at Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences

• NEW Octant Apprentice

• Head of Human Resource Business Partners

• Senior Scientist, In vitro pharmacology - Crinetics Pharmaceuticals

• Senior Director, In vitro pharmacology - Crinetics Pharmaceuticals

• In vivo Antibody Discovery Research Scientist

• In Vitro Biologist/Molecular Pharmacologist

Explore Dr. GPCR Ecosystem