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Results found for "Dr. Tim De Groof"
- GPCR Weekly Whirlwind: Top Receptor Highlights from Sep 30 - Oct 6, 2024!
Developing Nations If you reside and work in a developing country, complete this form for free access to Dr
- Cholesterol occupies the lipid translocation pathway to block phospholipid scrambling by a GPCR
membrane-embedded opsin indicated that phospholipid headgroups traverse a dynamically revealed hydrophilic groove cholesterol inhibits phospholipid scrambling by occupying the TM6/7 interface and stabilizing the closed groove
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- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
De novo drug design: AI algorithms can generate new molecules with desired properties, such as binding chemical space, limiting their ability to identify truly novel chemotypes”(Thomas, Smith, O’Boyle, de
- Therapeutic validation of an orphan G protein‐coupled receptor
Therefore, matching a ligand to an orphan GPCRs, the process of de-orphanizing, is of great importance
- Phospholipid Scrambling by G Protein-Coupled Receptors
dynamics simulations of opsin in a lipid membrane reveal conformational transitions that expose a polar groove This groove enables transbilayer lipid movement, conceptualized as the swiping of a credit card (lipid
- Isoform-and ligand-specific modulation of adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
Our work provides proof of concept for the modulation of isoform- and ligand specific aGPCR functions
- Finding needles in haystacks: Omass unveils pipeline aimed at tough-to-drug targets
November 2021 "Nov. 15, 2021 LONDON – There’s not yet proof of the pudding, but Omass Therapeutics Ltd
- Profiling Immune Cell and Platelet Transcriptomes
The researchers conducted a comparative analysis with previous studies, notably the work by Groot-Kormelink
- Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
This proof-of-concept study suggests the use of fluorescent ligands for GPCR characterization through
- A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands ...
In a proof-of-principle study, we succeeded in showing that our CCR9-PROTAC is able to reduce CCR9 levels
- G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..
GPR3-mediated G protein and β-arrestin signaling produce discrete and separable effects and provide proof
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
Bénard, G., Ramos, A., Reguero, L., Arrabal, S., Elezgarai, I., Gerrikagoitia, I., Suarez, J., Rodríguez De
- Rescue of Cell Surface Expression and Signaling of Mutant Follicle-Stimulating Hormone Receptors
aid in advancing the understanding of the effects of genetic mutations on GPCR function and provide a proof
- Why Biotech Fundraising Fails Due to Intellectual Property Gaps
Founders often present patents as proof of strength, while investors read them as indicators of risk
- Regulators of G-protein signaling: essential players in GPCR signaling
in their structural complexity, some members of the RGS family are selective for certain GPCRs, as a proof
- A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
.; Van De Veen, W.; Akdis, M.; Ortega-Gutiérrez, S.; López-Rodríguez, M. L.; Akdis, C.
- Glyco-sulfo hotspots in the chemokine receptor system
post-translational modifications (PTMs), contribute to the high affinity binding to the positively charged groove
