Search Results

So far, numerous therapeutics targeting GPCRs have been developed, with a focus on small molecules and

They include small molecules that conditionally modulate proteins in their functional state; three-dimensional

studied by protein mapping using the FTMap server, which determines the clustering of small organic probe molecules

approximately 850 GPCRs) has been successfully drugged, and obtaining highly potent and selective small molecules

phosphorylation sites are required for recruitment of the adaptor protein STAM1 (signal-transducing adaptor molecule

The development of new CB2-related pharmacological and genetic tools, including the first small molecule

parameters of serotonin1A receptors in normal cells are consistent with models describing the diffusion of molecules

This talk gave a general idea of what goes into designing small molecule drugs, using state-of-the-art

Pharmacological targeting of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717,

this accuracy to synthetic compounds, limiting its utility in drug discovery involving novel drug-like molecules

Here, we describe new tools, referred to as "SynTAMs" for synaptic targeting molecules, that enable localized

essential in biology and understanding how cells integrate signals from a variety of information-coding molecules

Ambiguous Decision Gates: Molecules advance or stall based on vibes, not criteria.

This was because, at that time, the neurexins, another family of adhesion molecules that also happened one of my colleagues to join this select group, which was getting together to talk about my favorite molecules

But in allosteric systems , adding a modulator doesn’t push another molecule off—it transforms the receptor

One of the atoms in the original molecule is replaced by a radionuclide, which emits radiation.

Adrenergic receptors on B cells and intracellular β2-ADR downstream molecules (G protein-coupled receptor

Tissue expression levels of β-Arrestins and their implications in cancer In addition to molecular interactions

Despite decades of research on the signaling consequences of molecule-receptor interactions, conformational

Originally developed as ultra-bright lanthanide probes, the team realized they could tune these molecules

This week’s Terry’s Corner  exposes the unseen physiological “opponents” your molecule faces—and how

Fluorescent ligands based on small molecules bind to the functional sites of receptors in live cells,

Ingo Hartung : State-of-the-art design of small molecule drugs, including PROTACs Dr.

peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule

This means you can design molecules that potentiate beneficial pathways without shutting down basal signaling

Breakthroughs this week:  5-MeO-DMT: the "God Molecule"; Novo Nordisk looks to next generation of obesity

operate on the principle of energy transfer between a fluorescent or luminescent donor and acceptor molecules

Administration of Exendin-4 to MI rats reduced the infarct size and reversed the aforementioned signaling molecules

proteins has been implicated in a range of diseases, and understanding the mechanisms of these complex molecules

highly expressed by olfactory sensory neurons of the nose where they are activated by different odorant molecules