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Results found for "translational research"
- Why Biotech Fundraising Fails Due to Intellectual Property Gaps
Patents focused on one indication, while the business story targets another 👉 Claims that protect research
- 📰 GPCR Weekly News, May 22 to 28, 2023
November 2 - 4, 2023) GPCR Jobs NEW Associate Director / Director, Clinical Operations Postdoctoral Research
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
Additionally, deep mutational scanning can generate large-scale datasets, allowing researchers to determine
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
cannot adequately predict protein structure (Jumper et al., 2021) ); 3) the same limitation holds when searching models, such as deep learning neural networks, are often referred to as "black boxes" because they lack transparency Efforts will likely be made to develop AI models that can provide transparent explanations for their Automated tools for researchers: AI solutions which bring together theoretical, computational, and experimental Instead, it complements and assists researchers in the GPCR drug discovery process.
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
This research further clarified the underlying role of β-arrestin2 and provided an experimental foundation
- Ode to GPCRs
Therefore, the presentation of 10 or more Nobel prizes highlights the importance of research work on the primary physiological and chemical visual processes in the eye.[7–11] Through Nobel prize-winning research Prize in Physiology or Medicine went to Eric Richard Kandel, Arvid Carlsson, and Paul Greengard for research Therefore, we envision that this field will continue to produce high-impact research work that will garner ACS Pharmacol Transl Sci 3, 221–236 (2020). https://pubs.acs.org/doi/full/10.1021/acsptsci.0c00006/.
- Chemokine receptor-targeted drug discovery: progress and challenges
the notion that redundancy is not a feature of the chemokine system (Nedjai et al. 2012), but more research
- 📰 GPCR Weekly News, February 27 to March 5, 2023
Methods & Updates in GPCR Research Time- and cost-efficient bacterial expression and purification of
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
GPCRs functional selectivity Recent research has revealed a more intricate understanding of GPCR behavior
- Targeting Intracellular Allosteric Sites in GPCRs
Recent advances in structural biology have allowed researchers to visualize the binding of allosteric
- 📰 GPCR Weekly News
Methods & Updates in GPCR Research Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking
- Odorant receptors – a bit of smell for drug discovery
Future directions Important directions in ORs research to advance drug discovery include the deorphanization
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
Neurochemical research, 42(1), 166–172. https://doi.org/10.1007/s11064-016-2026-6 Mendizabal-Zubiaga,
- Overview of adhesion GPCRs self-activation
knowing the factors that determine the selectivity of coupling represents a very interesting area of research
- Decoding β-Arrestins: from Structure to function
dissociation of crucial effector proteins within distinct subcellular locations remains a fundamental research
