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Results found for "pain research"
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system
- In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
perception, and thought, and have the activation of serotonin (5-HT) 2A receptors (5-HT2A Rs) as a main
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system
- G protein-coupled receptors that influence lifespan of human and animal models
substantial participation in a wide variety of processes of human pathophysiology and are one of the main
- TLR4 biased small molecule modulators
Currently, attention was mainly paid to biased signaling modulators targeting G protein-coupled receptors
- The Imprecision Problem: Why Your GPCR Drug Discovery Program Is Off-Track Before It Even Starts
And when you chain your highest-paid scientists to repetitive admin work, you’re not solving problems That’s a chaos tax — and you’re paying it in cash, time, and morale.
- A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
We aimed to exploit other mamba venoms to enlarge the V2R-Kunitz peptide family and gain insight into
- Target Residence Time: The Hidden Driver of In Vivo Efficacy
In This Session, You’ll Gain: ✅ Modeling tools to understand how restricted diffusion in tissues like
- Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic ...
Gaining control over disease-related events in non-alcoholic steatohepatitis (NASH), an advanced form
- Why “Displacement” Misleads You: Allosteric Binding Demystified
In This Session, You’ll Gain: ✅ A clear explanation of why allosteric modulators don’t displace ligands—they
- Why Intracellular Drugs May Hold the Key to GPCR Therapeutics
In this session, you’ll gain: ✅ A clear breakdown of how intracellular vs. extracellular receptor access
- Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of ...
While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point
- The Hidden Operating Cadence That’s Actually Driving Your Biotech
Many early-stage biotechs show the same pattern: strong scientific progress paired with an operating discipline, the organization typically shifts from “busy but slightly lost” to “focused, aligned, and gaining
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
the interactions of SMO with cholesterol and other lipid molecules in the ciliary membrane, and to gain
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent the main
- Curve Shifts Don’t Lie, But Your Eyes Might
In This Session, You’ll Gain: ✅ The ability to calculate how many replicates you really need for 95% By comparing two means (paired or unpaired) you’ll learn whether the divergence is genuine or whether
- Accelerating GPCR Drug Discovery: What 40 Years of Pharmacology Reveal
In this session, you’ll gain: ✅ Proven strategies to balance in vitro vs. in vivo testing early — when
- Orthosteric vs. Allosteric Interactions: The Silent Decider of Safety and Success
In this session, you’ll gain: ✅Clarity on Definitions: What truly distinguishes orthosteric from allosteric
- Why Opposing Processes Matter for Your Next GPCR Drug
In this session, you’ll gain: ✅ A mental model you can trust for predicting how GPCR ligands behave
- Beyond Clearance: The Strategic Power of Irreversible Drug Binding
In this lesson, you'll gain: ✅ Clarity on what “irreversible” really means in kinetic and pharmacologic
- From Snapshots to Predictions: Why Mechanism of Action Matters
In This Session, You’ll Gain: ✅ How to turn descriptive snapshots into predictive insights ✅ Tools to What looked like four conflicting behaviors turned out to be one coherent mechanism , hidden in plain
- Orthosteric Binding Experiments: How to Avoid the Most Common Data Pitfalls
In this session, you’ll gain: Why saturation and displacement assays fail when protein stoichiometry
- GPCR Pharmacology Insights That Prevent Real Drug Discovery Failures
In this session, you’ll gain: How system sensitivity transforms potency, efficacy, and agonist classification
