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August 2022 "Chemokines, a subgroup of cytokines along with their receptors, are involved in various of SDF-1 to CXCR4 initiates several intracellular signaling pathways, regulating cell proliferation, survival

August 2022 "GPR21 is an orphan and constitutively active receptor belonging to the superfamily of G-Protein

protein-coupled receptors (adhesion GPCRs), as a member of the G protein-coupled receptors (GPCRs) superfamily

August 2022 "Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled

An analysis of mutual interactions of subunits in the C5aR1-G protein complex has provided new insights details of local and global changes in the transmembrane domain induced by interactions with the Gα subunit

August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational used TIRF microscopy and a statistical method to track and classify the motion of different receptor subpopulations We showed a diversity of ligand-free forms of CCR5 at the cell surface constituted of various oligomeric These results suggest a link between receptor activation and immobilization.

GPCR crystallography, inserting a fusion protein between transmembrane helices 5 and 6 is a highly successful determination of GPCRs alone without signaling protein, the critical determinants that make this approach successful

Molecular dynamics simulations support the local conformational flexibilities and different stabilities

HTR1E stable cells with NF-α1/CPE increased pERK 1/2 and pCREB levels which prevented a decrease in pro-survival Cell survival assay in β-arrestin Knockout HEK293 cells showed that the NF-α1/CPE-5-HTR1E-mediated protection Immunofluorescence studies showed 5-HTR1E and NF-α1/CPE are highly expressed and co-localized on cell surface

GRK2 was shown to be expressed in human neutrophils and analysis of subcellular fractions revealed a

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface. Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent

glutathione-S-transferase) and analysis of the N267K mutation in the fibronectin type III domain 1 (FnIII.1) suggest Our data support the idea of a modulatory role of anosmin 1 in the biological effects controlled by the

August 2022 "Emerging evidence suggests that G protein-coupled receptor (GPCR) kinases (GRKs) are associated Here, we determine that GRKs phosphorylate a non-canonical substrate, anterior pharynx-defective 1A (

Studies have indicated that transmembrane helix 7 (TMH7) and the highly conserved NPXXY motif can be subject

For complete details on the use and execution of this protocol, please refer to Wei et al. (2022) and Sušac

We now summarize important pharmacological, molecular, and cellular studies relevant to D1-mediated β-arrestin-related

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expected to further enrich the understanding of C5a-C5aR2 interaction compared to C5a-C5aR1, which will surely

C1-inhibitor (C1INH) is a protease inhibitor present in plasma but not in isolated platelet suspensions The platelet suspensions were exposed to PAR1 agonists SFLLRN, TFLLR and TFLLRN; PAR4 agonists AYPGKF

We then demonstrate that sub-cellular localization and alternative signaling pathways may be responsible Our results suggest that strategies to selectively target OGR1 expression may represent a novel therapeutic

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface. Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent

cells, stimulation has been associated with increased invasion and MMP-9 expression, leading to the suggestion

However, the activation profiles of the GPR15 receptor within Gi/o subtypes have not been examined. Within the Gi/o family, the GPR15 receptor activates all the subtypes (Gi1 , Gi2 , Gi3 , GoA , GoB and The potencies of both peptides toward each Gi/o subtype have been determined.

grade in the HCC patients; (c) besides HCC (p < 0.001), RGS20 was found to be an important factor for survival Our analysis further supports the putative function of RGS proteins, particularly RGS20, in cancer."

pivotal role in removal of toxins and efflux of endocannabinoids to prevent excessive inflammation and sustain

These structures show that ZCZ011 binds to an extrahelical site in the transmembrane 2 (TM2)-TM3-TM4 surface In contrast, ORG27569, a negative allosteric modulator (NAM) of CB1, also binds to the TM2-TM3-TM4 surface

Functional studies showed that GASP1 knockout significantly suppressed malignant properties of breast and decreases their cellular response to paclitaxel by interacting with and stabilizing IGF1R, and suggests

The change of β2-ADR expression and signaling during sustained inflammation might be an integral part

September 2022 "The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes Several S1PR therapeutic drugs have been developed to treat these diseases; however, they lack receptor subtype The structure demonstrates a unique ligand-binding mode, involving an allosteric sub-pocket, which clarifies the receptor subtype selectivity and provides a template for structure-based drug design.