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August 2022 "Chemokines, a subgroup of cytokines along with their receptors, are involved in various of SDF-1 to CXCR4 initiates several intracellular signaling pathways, regulating cell proliferation, survival

August 2022 "GPR21 is an orphan and constitutively active receptor belonging to the superfamily of G-Protein

protein-coupled receptors (adhesion GPCRs), as a member of the G protein-coupled receptors (GPCRs) superfamily

August 2022 "Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled

An analysis of mutual interactions of subunits in the C5aR1-G protein complex has provided new insights details of local and global changes in the transmembrane domain induced by interactions with the Gα subunit

August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational used TIRF microscopy and a statistical method to track and classify the motion of different receptor subpopulations We showed a diversity of ligand-free forms of CCR5 at the cell surface constituted of various oligomeric These results suggest a link between receptor activation and immobilization.

Molecular dynamics simulations support the local conformational flexibilities and different stabilities

GPCR crystallography, inserting a fusion protein between transmembrane helices 5 and 6 is a highly successful determination of GPCRs alone without signaling protein, the critical determinants that make this approach successful

HTR1E stable cells with NF-α1/CPE increased pERK 1/2 and pCREB levels which prevented a decrease in pro-survival Cell survival assay in β-arrestin Knockout HEK293 cells showed that the NF-α1/CPE-5-HTR1E-mediated protection Immunofluorescence studies showed 5-HTR1E and NF-α1/CPE are highly expressed and co-localized on cell surface

GRK2 was shown to be expressed in human neutrophils and analysis of subcellular fractions revealed a

August 2022 "Emerging evidence suggests that G protein-coupled receptor (GPCR) kinases (GRKs) are associated Here, we determine that GRKs phosphorylate a non-canonical substrate, anterior pharynx-defective 1A (

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface. Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent

glutathione-S-transferase) and analysis of the N267K mutation in the fibronectin type III domain 1 (FnIII.1) suggest Our data support the idea of a modulatory role of anosmin 1 in the biological effects controlled by the

Studies have indicated that transmembrane helix 7 (TMH7) and the highly conserved NPXXY motif can be subject

For complete details on the use and execution of this protocol, please refer to Wei et al. (2022) and Sušac

We now summarize important pharmacological, molecular, and cellular studies relevant to D1-mediated β-arrestin-related

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show that the combination of pGRP with PTK2 inhibition or of pGRP with pCIB > pCIBm in additive ways suppressed The suppressive rather than activating effects of pGRP were confined to blood flow at a high shear rate This work thereby supports the role of PTK2 in integrin αIIbβ3 activation and signaling."

Recent studies introducing setmelanotide, a novel synthetic MC4R agonist, suggest a predominant role In summary, our study shows that inhibiting homodimerization has a setmelanotide-like effect on Gq/11

aggressive primary brain tumor, characterized by its high chemoresistance and the presence of a cell subpopulation , which extrude drugs outside the cell, such as the multidrug resistance-associated proteins (MRPs) subfamily These data suggest that hypoxia-dependent activation of A2B adenosine receptor promotes survival of GSCs

our transcriptomic analysis, expression of GPER was correlated with clinicopathological variables and survival value, 26.4% (95/360) of patients showed high GPER expression and significant correlation with the mRNA subtype In quantitative comparison, GPER abundance is correlated with the high-risk subtype of TNBC. Besides, high GPER expression was significantly linked to the worse survival in patients with lymph node These results may supply new insights into GPER-mediated estrogen carcinogenesis in TNBC, thus providing

In this work, we applied MD simulations supported by native mass spectrometry (nMS) to study lipid interactions This suggests differences in the regulatory function of PI(4,5)P2 between class A and class B GPCRs."

Abs against the angiotensin II receptor subtype 1 (AT1R) and the endothelin receptor type A (ETAR) are

September 2022 "GPCR signaling and function depend on their associated proteins and subcellular locations Furthermore, we found that certain GPCR ligands can regulate GPCR/14-3-3 signals temporally, suggesting

is remarkably increased under acute inflammatory stimuli such as lipopolysaccharide (LPS) and TNFα suggests highly upregulated in inflamed colon tissues of active ulcerative colitis (UC) patients and dextran sulfate CLH536, a novel GPR84 antagonist discovered by us, suppresses colitis by reducing the polarization and These results define a unique role of GPR84 in innate immune cells and intestinal inflammation, and suggest

The CX3C chemokine receptor 1 (CX3CR1), a member of the class A of G Protein-Coupled Receptors (GPCR) superfamily that characterize a functional state to contribute to the understanding of the complexity of the GPCR superfamily

"The follicle-stimulating hormone receptor (FSHR) belongs to the glycoprotein hormone receptors, a subfamily

September 2022 "Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafascicular

These results are supported by our recent work and present observations that show polymerization of G-actin