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Results found for "Structure Therapeutics"
- Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors
Crystal structures suggest ligand access to the orthosteric binding site of MT1 and MT2 receptors through
- GPCR Allosteric Modulation: Why Allostery is the Engine of Drug Discovery
This unpredictability isn’t chaos—it’s structure-driven , and when properly understood, it becomes a
- Precise druggability of the PTH type 1 receptor
PTHR signaling that could be extended to GPCRs to expedite discoveries of small molecules as novel therapeutic
- Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an important therapeutic
- Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation..
Our results suggest that strategies to selectively target OGR1 expression may represent a novel therapeutic
- Canonical chemokine receptors as scavenging “decoys”
The scavenging function of CKRs should be considered when evaluating the safety and therapeutic efficacy
- G protein-coupled receptors that influence lifespan of human and animal models
substantial participation in a wide variety of processes of human pathophysiology and are one of the main therapeutic
- Bursicon receptor gene HLGR2 as a potential RNA interference target for control of the fall ...
HLGR2 is a typical GPCR and shows high structural and sequence similarity with other insect LGR2 proteins
- Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...
regulating the PI3K/AKT/GSK-3β and MEK/ERK pathways in amygdalae of male mice, implicating a potential, therapeutic
- Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice
2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), is receiving renewed attention for their potential therapeutic
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the...
Our results suggest that GPR15/GPR15L have a pathogenic role in RA and their antagonizing could be a therapeutic
- PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Pc(4-4) may become a promising candidate for future therapeutic cancer treatment."
- G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..
discrete and separable effects and provide proof of concept for the development of safer GPCR-targeting therapeutics
- Allosteric Binding Demystified: Smarter GPCR Drug Discovery
Breakthroughs this week: Decoding ADGRE5 signaling; Eli Lilly’s obesity pill vs Novo’s Wegovy; Certa Therapeutics
- Crinetics Pharmaceuticals announced the formation of an independently operated new company...
stage pharmaceutical company focused on the discovery, development, and commercialization of novel therapeutics
- Twist Bioscience Launches Revelar Biotherapeutics to Develop and Commercialize Novel COVID-19...
Bioscience Launches Revelar Biotherapeutics to Develop and Commercialize Novel COVID-19 and Other Antibody Therapeutics
- High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
particularly aggressive and heterogeneous disease with few effective targeted therapies and precision therapeutic
- GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
and stabilizing IGF1R, and suggests that it may serve as a valuable prognostic factor and potential therapeutic
- How System-Level GPCR Thinking Prevents Discovery Failures
This feature from Celtarys Research outlines how to structure an HCS workflow that avoids batch effects
- TLR4 biased small molecule modulators
Biased pharmacological modulators provide potential therapeutic benefits, including greater pharmacodynamic
- The development of modulators for lysophosphatidic acid receptors: A comprehensive review
the current status of ligand development targeting LPA receptors to modulate LPA signaling and their therapeutic
- Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β-Arrestin ...
extensively studied GPCR that can provide insight into this aspect of GPCR signaling thanks to robust structural
- How to Design GPCR Drugs That Work in Vivo: Strategy, Tools, and Insights
Display | Manager, CMC Management | Translational R&D openings Must-read publications: New findings on structure-encoded
- How to Use Statistical Methods to Strengthen Every GPCR Drug Discovery Decision
Must-read publications: A structural modeling study revealing non-canonical mechanisms of chemokine-driven
- Targeted Activation of G-Protein Coupled Receptor-Mediated Ca 2+ Signaling Drives Enhanced Cartilage
manner, and triggered the formation of cell condensations that developed aligned, anisotropic neotissue structures
- Integrating Fluorescent Ligands into Flow Cytometry: Enhancing GPCR Analysis Beyond Traditional Antibody Staining
study biased signaling pathways, improving our understanding of GPCR functional diversity and their therapeutic
- Fluorescence Polarization in GPCR Research
compounds that interact with molecular targets involved in disease pathways is where the development of new therapeutics
- GPCR Allostery: Unlock Hidden Mechanisms and Make Smarter Drug Decisions
Leverage this model to stay ahead of therapeutic complexity.
- When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue
Realizing tissue is alive, unpredictable, and full of hidden structure.
- 📰 GPCR Weekly News
Detergent Rigidity-Flexibility Balance in Protein Stability. iORbase: a database for the prediction of the structures
