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Results found for "positive allosteric modulators"
- GPCRS: AN ODYSSEY FROM STRUCTURE, SIGNALING AND REGULATION TO THERAPEUTICS
dissect the molecular mechanisms of GPCR function has revealed new paradigms with increasingly complex models
- GPCR kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by...
In addition, we show that GPCRs that have similarly positioned C-tail phosphoresidues are also able to
- Comparative study of neuropeptide signaling systems in Hemiptera
from those of Heteroptera and Auchenorrhyncha, which was consistent with Sternorrhyncha's phylogenetic position
- How GPCR Spatial Signaling Sparked a Scientific Journey
Her early work didn’t involve groundbreaking receptor models or million-dollar grants.
- Molecular creativity in drug discovery
. • Training Builds Innovation : Her lab model at Monash is shaping the next generation of GPCR scientists
- Inversago Pharma appoints Glenn S. Vraniak as Chief Financial Officer
Vraniak to the position of Chief Financial Officer (CFO), effective immediately. Mr.
- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
The results show that the SK signal pathway plays a positive and significant role in feeding regulation
- Applications of Fluorescent Probes in Confocal Imaging of GPCRs: From Live to Fixed Cells
receptor localization in defined states (pharmacological stimulation, genetic modification, disease models
- First in Human: Early-stage COVID therapies hold promise against omicron variant
was first identified in South Africa in early November, and an existing treatment has already shown positive shots against the variant, the monoclonal antibody sotrovimab from Vir and partner GlaxoSmithKline PLC posted
- Unlock the Future of GPCR Science: Breakthroughs and Courses Await | Sep 2 - Sep 8, 2024
Senior Scientist/Staff Scientist, Computational Chemistry Postdoc in GPCR mechanosensing Postdoctoral Position Postdoctoral research position Adhesion GPCRs The N terminus-only (trans) function of the Adhesion GPCR
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
carried out MARTINI coarse-grained molecular dynamics simulations of SMO in POPC and in ciliary membrane models
- From Farm Fields to GPCR Discovery, GLP-1 and GIP
Studying the pancreatic islet — specifically the beta cells that release insulin — offered a unique model
- 📰 GPCR Weekly News, January 29 to February 4, 2024
β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52 Endosome positioning Pharmacology 2026 GPCR Jobs NEW Postdoctoral Fellowship- Mechanistic Biology NEW Research Scientist Post-Doc position Lead Researcher Senior Researcher in Structural Biology Post-Doctoral Fellow Join Dr.
- How Breakthroughs Happen: Eric Trinquet on Innovation, Serendipity & GPCRs
From probe solubility to photophysics, from tag strategies to model systems, every variable was debated
- 📰 GPCR Weekly News, October 9 to 15, 2023
the µ-Opioid Receptor Design and Synthesis of Novel GPR139 Agonists with Therapeutic Effects in Mouse Models signaling GPCRs in Oncology and Immunology Observational Study of Repeat Immunoadsorption (RIA) in Post-COVID
- Reflections on My PhD Journey: Lessons Learned
Whether positive or negative, controls ensure that your results are reliable and not the product of artifacts
- The Five Traps of Ignoring Kinetics
distilled from decades of pharmacology experience Whether you’re validating assays, refining kinetic models
- 📰 GPCR Weekly News, June 10 to 16, 2024
Pharmacology Postdoctoral Scientist Senior Research Associate/Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell Biology/Biochemistry Post Doctoral Fellow Postdoc Position Join Dr.
- Understanding the Journey: Catherine Demery's Path to Addiction Science
She gained exposure to in vivo models, immunology, and complex study design, while also getting closer
- Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the ...
Caenorhabditis elegans was used as an animal model, and both gene expression and functional analysis
- From Lab Logic to Leadership: How Scientific Thinking Holds Back Biotech Operations
✅ This post explores how scientific thinking can become a leadership liability and what mindset Explaining a model is not the same as rallying a team.
- Scientific Isolation: The Real Reason Early Biotechs Lose Traction
. 👉 What this layer requires: A crisp BD trajectory that evolves every quarter A 1–2 page positioning
- The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of ...
Animal models of CMV provide insights into their role in viral fitness.
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
regenerative pathway in the nervous system.SIGNIFICANCE STATEMENTIn C. elegans, axon regeneration is positively
- How to Design GPCR Drugs That Work in Vivo: Strategy, Tools, and Insights
Research – Optimizing HTRF with Fluorescent Ligands Traditional ligand-binding approaches risk false positives
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
late endosomal recycling markers, CCR2 was also shown to be rapidly sorted into fast-recycling Rab4-positive endosomes in a more sustained manner compared to the atypical scavenging receptor ACKR3, and Rab7-positive
- 📰 GPCR Weekly News, March 11 to 17, 2024
Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model
- Biased Agonism at the GLP-1 Receptor: A Pathway to Improved Therapeutic Outcomes
For example, in vivo studies in diabetic models have shown that although exendin-P5 induces lower insulin
- GPCR Binding Affinity Experiments: Interpreting Data With Confidence as We Head Into 2026
interactions observed by NMR; Endocrine Metabolic GPCRs 2026 and Biophysical Society Meeting previews; positive
- Advantages of Fluorescent Probes in GPCR Assays
provide real-time data on receptor activation, ligand binding and downstream signaling using live-imaging modalities













