📰 GPCR Weekly News, September 11 to 17, 2023

Hello GPCR people! Check out our GPCR roundup now, and be the first to read!

This week's highlights:

• Celebrating Dr. Robert Lefkowitz on his 50 years at Duke. Congratulations.

• Dr. Graeme Milligan and their colleagues research on Pro-phagocytic function and structural basis of GPR84 signaling.

• Congrats to Dr. Kevin Wright on his new position as Director of Targeted and Immuno-oncology at GPCR Therapeutics, our partner.

Mark your calendars for the following events:

• September 22- TOMORROW: Attend this Friday's Dr. GPCR Symposium on 'GPCRs as Therapeutic Modalities' with Richa Tyagi, Dr. Terry Kenakin, Dr. Oliver Hartley, Dr. Pierre Eftekhari, Dr. Lauren Slosky, Dr. Christel Menet, Dr. Ben Myers and Dr. Niña Caculitan. Since you are reading this newsletter, you only have to click on the event page to join us.

• November 2 - 4: We are sponsoring the GPCR Retreat and look forward to seeing you there! Registrations are closed but you can send an email to gpcrretreat@uottawa.ca to be added to the waitlist. If you have registered, please submit poster abstracts through this form and the short talk selections will be made. Abstract submissions close on October 2nd.

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Please take a look at the weekly Classified GPCR News from September 11th to 17th, 2023.

GPCR Activation and Signaling

• Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins

GPCR Binders, Drugs, and more

• Studying allosteric regulation of chemokines and antagonists using a nanoscale hCCR3 receptor sensor

GPCRs in Oncology and Immunology

• Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML

• miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population

• Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning

• Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma

Methods & Updates in GPCR Research

• Genetic atlas of hygro-and thermosensory cells in the vinegar fly Drosophila melanogaster

Structural and Molecular Insights into GPCR Function

• Pro-phagocytic function and structural basis of GPR84 signaling

• Structural diversity of leukotriene G-protein coupled receptors

Industry News

• Duke University Celebrates Nobel Prize Winner Robert Lefkowitz’s 50 Years of Scientific Discovery

• Novo Nordisk Foundation Grants Fuel Exciting GPCR and Signaling Protein Research Tools

• First-In-Class Drug Shows Potential for Treatment of Cannabis Use Disorder

• Reproducibility of Tanso Biosciences' GPCR Assay

• Septerna: making another run on GPCRs

• Addex Mglu2 Nam Cognition Program Receives €4 Million Grant

• Dr. Kevin Wright Joins GPCR Therapeutics as Director of Targeted and Immuno-oncology

• Sosei Heptares Adds World-leading Expertise to its Scientific Advisory Board

Call for GPCR Papers

• opnMe GPCR Route 66+ project. Deadline September 27, 2023

GPCR Events, Meetings, and Webinars

• September 25 - 28, 2023 | Discovery On Target

• September 27 - 28, 2023 | Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric Function and Biased Signaling" at the DOT

• NEW October 2 - 3, 2023 | Celebrating Robert J. Lefkowitz's Career at Duke

• October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting Membrane Proteins: from antigen production to candidate validation

• October 25 - 27, 2023 | 3rd Annual Meeting IRN I-GPCRNet

• November 2 - 4, 2023 | GPCR Retreat- Registration Closed

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 4, 2024 | Chemotactic Cytokines

GPCR Jobs

• NEW Research Technician II - Surgery

• NEW Post-Doc Research Associate

• NEW Research Technician

• Senior Research Associate, In Vitro Pharmacology - Crinetics Pharmaceuticals

• Postdoc In Cell Biology Of Protein Trafficking

• Postdoctoral Fellow

• Researcher / Senior Researcher in Structural Biology

• Research Specialist

Explore Dr. GPCR Ecosystem