Search Results

show that the combination of pGRP with PTK2 inhibition or of pGRP with pCIB > pCIBm in additive ways suppressed The suppressive rather than activating effects of pGRP were confined to blood flow at a high shear rate This work thereby supports the role of PTK2 in integrin αIIbβ3 activation and signaling."

Recent studies introducing setmelanotide, a novel synthetic MC4R agonist, suggest a predominant role In summary, our study shows that inhibiting homodimerization has a setmelanotide-like effect on Gq/11

aggressive primary brain tumor, characterized by its high chemoresistance and the presence of a cell subpopulation , which extrude drugs outside the cell, such as the multidrug resistance-associated proteins (MRPs) subfamily These data suggest that hypoxia-dependent activation of A2B adenosine receptor promotes survival of GSCs

our transcriptomic analysis, expression of GPER was correlated with clinicopathological variables and survival value, 26.4% (95/360) of patients showed high GPER expression and significant correlation with the mRNA subtype In quantitative comparison, GPER abundance is correlated with the high-risk subtype of TNBC. Besides, high GPER expression was significantly linked to the worse survival in patients with lymph node These results may supply new insights into GPER-mediated estrogen carcinogenesis in TNBC, thus providing

In this work, we applied MD simulations supported by native mass spectrometry (nMS) to study lipid interactions This suggests differences in the regulatory function of PI(4,5)P2 between class A and class B GPCRs."

Abs against the angiotensin II receptor subtype 1 (AT1R) and the endothelin receptor type A (ETAR) are

September 2022 "GPCR signaling and function depend on their associated proteins and subcellular locations Furthermore, we found that certain GPCR ligands can regulate GPCR/14-3-3 signals temporally, suggesting

is remarkably increased under acute inflammatory stimuli such as lipopolysaccharide (LPS) and TNFα suggests highly upregulated in inflamed colon tissues of active ulcerative colitis (UC) patients and dextran sulfate CLH536, a novel GPR84 antagonist discovered by us, suppresses colitis by reducing the polarization and These results define a unique role of GPR84 in innate immune cells and intestinal inflammation, and suggest

The CX3C chemokine receptor 1 (CX3CR1), a member of the class A of G Protein-Coupled Receptors (GPCR) superfamily that characterize a functional state to contribute to the understanding of the complexity of the GPCR superfamily

"The follicle-stimulating hormone receptor (FSHR) belongs to the glycoprotein hormone receptors, a subfamily

September 2022 "Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafascicular

These results are supported by our recent work and present observations that show polymerization of G-actin

Collectively, these findings reveal a unique hydrogen-bonding network located on intracellular loop 2 that is subject

proliferation through cAMP/protein kinase A signaling, consistent with AVPR2 coupling to the G protein subunit arginine vasopressin receptors, and knockout of AVP in CRPC cells significantly reduced proliferation suggesting

GPR39 is a GPCR which can interact with Zn and modulate the colonocytes' survival.

Surprisingly, phosphorylation of the RGS promotes completion of cytokinesis before pheromone-induced

Namely, CBD has been suggested to directly trigger receptor’s activation, stabilize CB1 inactive conformations In addition, our results suggest a previously unknown sodium-binding site located in the extracellular

member A (RhoA), exchange protein activated by cAMP (Epac), and transient receptor potential ankyrin subtype In this review, we discuss both the ‘friend’ and ‘foe’ features of TGR5 by summarizing its tumor-suppressing

Recent studies in experimental animals have shown that certain subsets of T cells express functional

myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL‐1β overproduction, thereby suggesting Trehalose is a disaccharide sugar with known pro‐autophagy activity and effective in alleviating diverse sought to investigate the therapeutic potential of autophagy‐enhancing agent, trehalose, or related sugar

Such effects are mediated by the suppression of gut IEL effector functions linked to the dampening of

We then highlight the evidence supporting the use of various drugs including orthosteric and allosteric

functions requiring high sensibility and specificity, T cells need to integrate different stimuli from the surrounding

Our data reveal the functional role of 5-HT2A–TrkB receptor heterodimerization and suggest that the regulated

This methylation on a lysine residue at the N-terminal portion of β-catenin suppresses the ubiquitination Our study demonstrates the importance of β-catenin lysine methylation in terms of its sustained expression

September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular

Depletion of GPR108 dramatically inhibited the survival of various cancers. Overall, our findings supported GPR108 as a promising therapeutic target of cancer, and provided a small

As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment

However, although necessary for some GPCRs, we found that distal C-tail sites might not be sufficient

One suggested theory is that cannabinoids regulate a variety of physiological processes within the cells demonstrated that 10 nM of ACEA notably amplified mRNA gene expression of NR4A1 and NR4A3; this effect was suppressed