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Results found for "positive allosteric modulators"
- From Lab Logic to Leadership: How Scientific Thinking Holds Back Biotech Operations
✅ This post explores how scientific thinking can become a leadership liability and what mindset Explaining a model is not the same as rallying a team.
- How to Design GPCR Drugs That Work in Vivo: Strategy, Tools, and Insights
Research – Optimizing HTRF with Fluorescent Ligands Traditional ligand-binding approaches risk false positives
- The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of ...
Animal models of CMV provide insights into their role in viral fitness.
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
regenerative pathway in the nervous system.SIGNIFICANCE STATEMENTIn C. elegans, axon regeneration is positively
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
late endosomal recycling markers, CCR2 was also shown to be rapidly sorted into fast-recycling Rab4-positive endosomes in a more sustained manner compared to the atypical scavenging receptor ACKR3, and Rab7-positive
- GPCR Binding Affinity Experiments: Interpreting Data With Confidence as We Head Into 2026
interactions observed by NMR; Endocrine Metabolic GPCRs 2026 and Biophysical Society Meeting previews; positive
- Biased Agonism at the GLP-1 Receptor: A Pathway to Improved Therapeutic Outcomes
For example, in vivo studies in diabetic models have shown that although exendin-P5 induces lower insulin
- 📰 GPCR Weekly News, March 11 to 17, 2024
Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model
- Advantages of Fluorescent Probes in GPCR Assays
provide real-time data on receptor activation, ligand binding and downstream signaling using live-imaging modalities
- 📰 GPCR Weekly News, April 8 to 14, 2024
self-secreted by yeast expressing a G-protein-coupled receptor Reviews, GPCRs, and more The GLP-1R as a model
- 📰 GPCR Weekly News, March 20 to 26, 2023
27, 2023) GPCR Jobs NEW Team Lead protein production and profiling NEW Pharmacologist Postdoctoral positions
- Why Biotech Fundraising Fails Due to Intellectual Property Gaps
A strong IP position is not defined by volume.
- ⛵Sailing the GPCR Seas: Your Weekly Research Voyage! ⦿ Nov 11 - 17, 2024
Reports Third Quarter 2024 Financial Results and Provides Business Update Aelis Farma announces the positive
- The Moment Biotech Founders Realize the Money Is Gone
primarily by cost, not by strategic value 2️⃣ Short-term deliverables consistently override long-term positioning
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
Results: On day 7 post-infraction, MI rats showed LV dysfunction with higher serum levels of cardiac Both can result in a positive inotropic effect.
- Exciting GPCR Events for Next Year! + GPCR Weekly Rocket Launch ⦿ Oct 28 - Nov 3, 2024
Job listings for candidates and positions to connect!
- Biotech Startup Failure: Why Teams Drift Off Course Without a Single Wrong Decision
. 👉 Early signals often look positive, which delays recognition of the deeper problem.
- Inside the New Dr. GPCR Ecosystem: Learning, Insight, and Momentum for 2026
Optimization is modular — activity, ADME, and safety can be tuned independently. Here's how: Watch the course trailer ➤ Read the blog post ➤ Subscribe to the Kenakin Brief ➤ Dr.
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
Moreover, whether octreotide or pasireotide may play modulatory effects and whether FLNA may participate
- TeachOpenCADD - A teaching platform for computer-aided drug design
programming packages for cheminformatics and structural bioinformatics are powerful tools to build modular











