Search Results
Results found for "Dr. GPCR ecosystem"
- 🚨 Exciting Opportunity for Professionals in Drug Development! 🚨 Register today for a one-of-a-kind online course at Dr. GPCR University: "Development of GPCR Ligands as Therapeutic Drugs." 🗓 Dates: March 20 - April 10, 2025 ⏰ Time: Thursdays, 10:00 AM - 11:30 AM (EST) This advanced course is essential for anyone working in drug development and focuses on: The essentials of new drug development Key pharmacokinetic elements (absorption, distribution, clearance) Hepatic metabolism and the Cytochrome P450 system Drug safety and toxicology (including drug-drug interactions) And much more! Gain deep insights into GPCR drug candidates and learn the critical assays and techniques required to bring therapeutic molecules to life. 🚨 Only 25 spots available — register now! 💡 This is a great opportunity for both academia and industry professionals. Sessions will be live, and you’ll also have 1:1 discussion time with the instructor. Full PDFs of the slides will be available! 🔗 https://buff.ly/lVEcRUc #GPCR #DrugDevelopment #Pharmacokinetics #TherapeuticDrugs #OnlineCourse #DrGPCRUniversity #PharmaceuticalIndustry | Dr. GPCR Ecosystem
🚨 Register today for a one-of-a-kind online course at Dr. GPCR University: "Development of GPCR Ligands as Therapeutic Drugs." 🗓 Dates: March 20 - April 10, 2025 DrGPCRUniversity #PharmaceuticalIndustry Published on March 12, 2025 Category Dr. 🚨 Register today for a one-of-a-kind online course at Dr. GPCR University: "Development of GPCR Ligands as Therapeutic Drugs." 🗓 Dates: March 20 - April 10, 2025
- GPCR Courses
GPCR University? Dr. How do I register for Dr. GPCR University Masterclasses? To register for any course, you must have a FREE Ecosystem member account . Who are the Dr. GPCR University Masterclasses designed for? We will contact each person individually to help them set up a FREE Ecosystem Membership .
- Ever wondered how we perceive bitterness? 👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14, the most promiscuous bitter taste receptor, bound to the drug flufenamic acid (FFA) and its signaling partner gustducin! 🌟 This discovery reveals an unusual dual binding mode of FFA and offers tools for site-targeted compound design. 🧪✨ Learn more about this exciting breakthrough in bitter taste signaling. | Dr. GPCR Ecosystem
Published on December 5, 2024 Category GPCR Weekly News Ever wondered how we perceive bitterness? receptor-activation-and-signaling/a-bitter-anti-inflammatory-drug-binds-at-two-distinct-sites-of-a-human-bitter-taste-gpcr 3ecb-4719-8ba3-974d17e9f596&utm_source=so&utm_medium=mail&cid=79a6b35e-7ba6-44a0-863b-0842f5a5cfd3 #gpcr
- 10 GPCR pharmacology lessons. Zero fluff. Launching July 1, Terry’s Corner gives you the clarity and confidence to make better decisions—starting with: • The role of pharmacology in discovery strategy • Black & Leff’s operational model—finally made practical • Binding curves, orthosteric vs allosteric function, and real vs apparent affinity • Molecular dynamics and how they guide ligand design • Why Terry built this—and how it sharpens your next move 📅 Learn anytime. New course every week. 📬 Subscribe to The Kenakin Brief → https://www.terrykenakin.com #GPCRscience #drugdiscovery #TerrysCorner #GPCRpharmacology #ligandbinding | Dr. GPCR Ecosystem
Home → Flash News → 10 GPCR pharmacology lessons. Zero fluff. TerrysCorner #GPCRpharmacology #ligandbinding Published on June 30, 2025 Category Terry's Corner 10 GPCR
- How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs? New cryo-EM structures from Chen et al. (Nature, 2025) reveal that β-arrestin1 and β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping arrestin conformation, complex stability, and engagement mode. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Also, β-arrestin2 lacks a membrane anchor, making it more dynamic — a potential clue to its functional specialization. These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR | Dr. GPCR Ecosystem
Home → Flash News → How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias barcodes influence β-arrestin binding to GPCRs? Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #
- Think βCGRP is just αCGRP’s understudy? Think again. New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor family, challenging the long-held assumption of redundancy. 🔬 A closer look reveals differences in G protein coupling, second messenger production, and receptor trafficking. 📊 This could reshape how we understand CGRP-related physiology—and how we target it in drug design. 🧠 Pain, inflammation, metabolism: the implications go far beyond signaling bias. 🔗 Read the full paper in Biochemistry: Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors #GPCR #CGRP #DrugDiscovery #Pharmacology #SignalTransduction #Neuropeptides | Dr. GPCR Ecosystem
Read the full paper in Biochemistry: Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors #GPCR #DrugDiscovery #Pharmacology #SignalTransduction #Neuropeptides Published on June 16, 2025 Category GPCR Read the full paper in Biochemistry : Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors #GPCR
- Timeline Strategy | Scaling Biotech Operations with Dr. GPCR
Discover how Timeline Strategy helps GPCR innovators scale their organizations through strategic planning Home: Welcome Timeline Strategy x Dr. GPCR — Scaling Biotech Beyond the Bench Turning scientific excellence into scalable organizations. Building the Strategic Backbone of GPCR Innovation In the rapidly evolving GPCR field, scientific progress Together with Dr.
- Illuminating Functional Selectivity and Allosterism at GPCRs.
schedule Illuminating Functional Selectivity and Allosterism at GPCRs. Date & Time Saturday, November 4th / 11:30 AM Abstract Coming Soon About Stéphane Laporte "Dr. Stéphane Laporte on the web Laporte Lab McGill University LinkedIn Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Biochemical Mechanisms Underlying Location Bias in GPCR Signaling
4th / 8:40 AM Abstract Coming Soon About Sudarshan Rajagopal "Dr. During his Cardiology fellowship, he trained in the lab of Dr. Robert J. Sudarshan Rajagopal on the web The Rajagopal Lab Google Scholar Pubmed LinkedIn Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- G Proteins and GPCRs in Cancer: Novel Precision Targeted and Immunotherapies
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to Silvio Gutkind "Dr. Diego Moores Cancer Center Gutkind Lab publications Pubmed LinkedIn Twitter UCSD Moores Cancer Center Dr GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Developing a PROTAC to Degrade the Constitutively Active Onco-GPCR in Uveal Melanoma
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to Friday, November 3rd / 4:20 PM About Victoria Rasmussen "Victoria Rasmussen is a graduate fellow in Dr therapeutic strategy. " Victoria Rasmussen on the web Tri-Institutional PhD Program Chemical Biology LinkedIn Dr GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways
Dr. Dr. Dr. Dr. 22nd GPCR Retreat Sponsored by
- The Practical Assessment of Signaling Bias | Dr. GPCR Ecosystem
The Practical Assessment of Signaling Bias Dr. Terry Kenakin < Back Workshop Summary Join Dr. Dr. Dr. Dr. Terry Kenakin’s workshop offers a fresh perspective on drug discovery .
- Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to Dr. Heidi Hamm on the web The Hamm Lab Vanderbilt School of Medicine Pubmed Google Scholar LinkedIn Twitter Dr GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Unveiling Non-Canonical Functions for Gαq Signaling Pathways
The research group led by Dr. In Spain, Dr. Ribas continued working on the regulation of GPCR. The group of Dr. Recently, Dr. Furthermore, Dr. 22nd GPCR Retreat Sponsored by
- Trainee Symposium I
Eric Johansen on the web Johns Hopkins University Dr. Grace Mazarura on the web McGill University Dr. Émile Breault on the web Google Scholar ResearchGate Dr. Bassam Albraidy on the web X (Twitter) LinkedIn Dr. 22nd GPCR Retreat Sponsored by
- Regulation and role of mitochondria delta opioid receptors
opioid receptors Date & Time Friday, November 3rd / 10:40 AM Abstract Coming Soon About Louis Gendron "Dr Dr Gendron is co-director of the FRQS-funded Quebec Pain Research Network and the Editor-in-Chief in the web Université de Sherbrooke Neurosciences Sherbrooke RQRD Pubmed Google Scholar LinkedIn Twitter Dr GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Cannabinoid compounds to augment L-DOPA treatment in Parkinson's Disease
His PhD work was under the supervision of Dr. In November of 2002, he joined the lab of Dr. In the Caron lab, Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Trainee Symposium II
In November 2021, I joined Dr. Amr Mousa on the web Google Scholar Dr. Louis-Philippe Picard on the web Google Scholar Dr. Dr. 22nd GPCR Retreat Sponsored by
- Structure-based discovery of functionally selective 5-HT1A receptor agonists
Dr. Peter Gmeiner received his Ph.D. from the University of Munich. Upon receiving his Dr. Gmeiner on the web Friedrich Alexander University Erlangen-Nürnberg Pubmed Google Scholar LinkedIn Dr GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- A positive Allosteric Modulator of M1 Acetylcholine Receptors Improves Cognitive Deficits in Male and Female Alzheimer’s Mice
Male and Female Alzheimer’s Mice Date & Time Friday, November 3rd / 1:55 PM About Khaled Abdelrahman Dr He joined the laboratory of Dr. In 2015, He joined Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Dopamine-Mediated Motor Recovery after Ischemic Stroke
Pierre-André Lavoie and Dr. Jacques Magnan, respectively. I then pursued my postdoctoral training at Duke University in the laboratory of Dr. Mario Tiberi on the web University of Ottawa Pubmed Google Scholar ResearchGate LinkedIn Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Targeting adenosine signaling for immuno-oncology
Distinguished immunologist, Dr Stagg is recognized for having identified the adenosine-producing enzyme Dr Stagg has served as an expert consultant in the development of adenosine-targeting drugs, several Dr Stagg is a member of the Board of Directors of BioCanRx, Canada's Immunotherapy Network, co-founder GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling
Since then, Dr. Dr. Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Complex Allosteric Cannabinoid Receptor Pharmacology
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to Pharmacology Date & Time Friday, November 3rd / 11:30 AM Abstract Coming Soon About Robert Laprairie "Dr Laprairie on the web University of Saskatchewan Pubmed Twitter Instagram ResearchGate Google Scholar Dr GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Interrogating Multiscale Receptors Functions in Space
Prior to his recruitment Dr. Dr. Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
- Genetic Deletion of Atypical VGLUT3 Rescues Huntington’s Disease Phenotype and Neurodegeneration in zQ175 Mice
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to Karim Ibrahim on the web X (Twitter) Google Scholar Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by
- Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer
Ovarian Cancer Date & Time Friday, November 3rd / 3:55 PM Abstract Coming Soon About Robert Rottapel "Dr Dr. Rottapel is a clinical rheumatologist at St. Michael's Hospital, University of Toronto. Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by
