Gaining control over disease-related events in non-alcoholic steatohepatitis (NASH), an advanced form

While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point

receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent the main

& Updates in GPCR Research A bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation

: 38758649 Member Simone Prömel’s lab shows that the nematode (C. elegans) homolog of CELSR, FMI-1, modulates

The G-protein-coupled receptors in the human genome form five main families.

animals — a milestone that demonstrated just how powerful well-engineered chemical tools can be when paired JB gained a grounded understanding of tissue heterogeneity, signal variability, and the biology that

What did you decide not to pursue to strengthen the main thesis?

believe they are still building the company, while in reality, they have already shifted into survival mode and partnerships are delayed, not by strategy, but by fear of cash burn 4️⃣ Fundraising becomes the main control requires catching this transition early, before survival thinking becomes the default operating mode

understanding of how various factors, such as lipid composition, osmotic stress, and allosteric ligands, modulate Interaction of G-Protein βγ Complex with Chromatin Modulates GPCR- Dependent Gene Regulation.