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GPCR Summit from October 10th to the 16th is taking shape. GPCR Ecosystem site member, which is free! Sign up now ➡️ https://bit.ly/3eaO5PH #gpcr #drgpcr

GPCR Summit 2022. This is a great opportunity for us to come together and talk GPCRs. Join us now ➡️ https://www.ecosystem.drgpcr.com/dr-gpcr-summit-2022 #gpcr #drgpcr

December 2021 "30/11/2021 Confo will work together with Regeneron to apply its GPCR drug discovery platform VIB spin-off Confo Therapeutics today announced that it has entered into a collaborative agreement with technology platform, which uses conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs in disease-relevant conformations, will be applied with the goal of enabling the discovery of novel therapeutic antibody drug candidates. " Read more at the source #DrGPCR #GPCR #IndustryNews

April 2022 Addex Therapeutics Completes Patient Enrollment For Dipraglurant Blepharospasm Phase 2 Clinical Study "Geneva, Switzerland, April 13, 2022 - Addex Therapeutics Ltd (SIX: ADXN, Nasdaq: ADXN), a clinical-stage Read more at the source #DrGPCR #GPCR #IndustryNews

Molecular innovation This Week’s GPCR Intelligence: The next edge in discovery isn’t louder exposure—it Breakthroughs this week:  nanomedicines targeting PAR2 for sustained analgesia; Emerging Voices in GPCR Biology; Domain Therapeutics patents new PAR2 antagonists. 🔍 This Week in Dr. GPCR Premium: Sneak Peek Industry insights:  Confo VLAIO grant; Skye CB1 Ph2 miss; Chugai CT-388 in-license Upcoming events:  Membrane-mimetic screening; GPCR Forum 2025; GPCR-TDD Summit Europe.

GPCR Summit 2022. Mark your calendar for October 10th and 16th. ➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr

➡️ https://bit.ly/3wQNZDg #gpcr #drgpcr

G protein-coupled receptors (GPCRs) have been shown to play integral roles in Alzheimer's disease pathogenesis However, it is unclear how diverse GPCRs similarly affect Aβ and tau pathogenesis. GPCRs share a common mechanism of action via the β-arrestin scaffolding signaling complexes, which not only serve to desensitize GPCRs by internalization, but also mediate multiple downstream signaling events As signaling via the GPCRs, β2-adrenergic receptor (β2AR), and metabotropic glutamate receptor 2 (mGluR2

Chemokine receptors (CKRs) belong to a subfamily of G-protein-coupled receptors (GPCRs) and play a crucial helix (TM7) near ECL3, while the other links TM3 with ECL2, which is common to the broader class A GPCR In addition, it has a glutamate residue at position 3.45, which is not found in human class A GPCRs, binding and receptor activation will pave the way for significant advancements in the development of therapeutics Check the original article at https://pubmed.ncbi.nlm.nih.gov/37212620/ #GPCR #DrGPCR #Ecosystem

G protein-coupled receptors (GPCRs) are among the most promising drug targets. Specifically controlling the activity of GPCR dimers with ligands is a good approach to clarify their This region corresponds to the sodium ion binding site in class A GPCRs that controls the basal state reveal the possibility of developing allosteric compounds able to specifically modulate the activity of GPCR

August 2022 "Geneva, Switzerland, August 18, 2022 - Addex Therapeutics (SIX and Nasdaq: ADXN), a clinical-stage Read more at the source #DrGPCR #GPCR #IndustryNews

are pursuing AI-driven drug discovery to explore new functional chemical space and precision-engineer therapeutics with enhanced potency and tailored signaling against an undrugged GPCR target. #ai #drugdiscovery #gpcr" Read more at the source #DrGPCR #GPCR #IndustryNews

March 2022 Confo Therapeutics Doses First Subjects In Phase 1 Clinical Trial Of CFTX-1554 For The Treatment Confo’s first drug candidate moves into clinical development — Ghent, Belgium – March 10, 2022 – Confo Therapeutics , a leader in the discovery of medicines targeting G-protein coupled receptors (GPCRs), today announced pharmacokinetics of CFTX-1554 in healthy subjects (NCT05260658). " Read more at the source #DrGPCR #GPCR

This approach reveals: Hidden target overlap New therapeutic hypotheses “Off-target” effects that may GPCRs are not simple on/off switches. This reroutes discovery toward: Functionally selective ligands Better therapeutic windows More predictable What matters now is not the category , but the fit: Does the chemical matter support the therapeutic GPCR innovation is accelerating.

December 2021 "Geneva, Switzerland, December 17, 2021 – Addex Therapeutics Ltd (SIX: ADXN and Nasdaq: Read more at the source #DrGPCR #GPCR #IndustryNews

November 2022 "Some G protein-coupled receptor (GPCR) ligands act as "biased agonists" that preferentially Although GPCRs are primarily found at the plasma membrane, GPCRs can traffic to and signal from many subcellular signaling contributes to the biased signaling generated by three endogenous ligands of the GPCR observed at CXCR3, which has important implications for drugs targeting chemokine receptors and other GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter HERE

October 2022 "G protein-coupled receptors (GPCRs) are of considerable interest due to their importance physiological functions and in a large number of Food and Drug Administration (FDA)-approved drugs as therapeutic signaling effectors: heterotrimeric G proteins, GPCR kinases (GRKs), and β-arrestins. As new technologies are developed and applied to studying GPCR structure and their downstream effectors Read more at the source #DrGPCR #GPCR #IndustryNews

July 2022 "Ad Hoc Announcement Pursuant to Art. 53 LR Geneva, Switzerland, July 22, 2022 – Addex Therapeutics issuance and will expire five years from their date of issuance. " Read more at the source #DrGPCR #GPCR

demonstrate that the chemoreceptor genes, srg-36 and srg-37, which encode G protein-coupled receptors (GPCRs Here, we show that SRG-36 and SRG-37 act as upstream GPCRs that activate EGL-30. SRG-36 and SRG-37 are GPCRs for the dauer-inducing ascaroside, ascr#5. Thus, ascaroside signaling promotes axon regeneration by activating the GPCR-Gqα pathway.

Read more at the source #DrGPCR #GPCR #IndustryNews

In his collaboration with David Hodson, every major leap—from early ligand design to GPCR visualization Throughout his own journey—from organic chemistry to chemical biology to GPCR imaging—every pivotal step  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization

signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened "The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of of HH to the apico-basal distribution of SMO and provide a novel mechanism for the regulation of a GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

are involved in mGlu5a receptor internalization "The internalization of G protein-coupled receptors (GPCRs Additionally, using the Gαq/11 inhibitor YM-254890, GPCR kinase 2 and 3 (GRK2 and GRK3) KO cells, and Our PKC KO cell lines expand the repertoire of KO HEK293A cell lines available to research GPCR pharmacology Read more at the source #DrGPCR #GPCR #IndustryNews

Notably, while CBD is able to antagonize some GPCRs in the endocannabinoid system, it also seems to activate we investigate the interacting determinants of CBD in two closely related endocannabinoid-activated GPCRs the CBD ligand in the GPR55 receptor elicit conformational changes associated with antagonist-bound GPCRs way for understanding the CBD pharmacology at a molecular level and aid in harnessing its potential therapeutic Read more at the source #DrGPCR #GPCR #IndustryNews

ubiquitously expressed membrane proteins that associate with different G protein–coupled receptors (GPCRs ), including the parathyroid hormone 1 receptor (PTH1R), a class B GPCR and an important modulator of These data uncover a critical role of RAMPs in the activation and signaling of a GPCR that may provide a new venue for highly specific modulation of GPCR function and advanced drug design." Read more at the source #DrGPCR #GPCR #IndustryNews

The pace of GPCR innovation is accelerating—teams acting on today’s insights will set tomorrow’s standards

September 2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate Serotonin1A receptors are important members of the GPCR family and are implicated in neuropsychiatric To explore the role of cholesterol in lateral dynamics of GPCRs, we utilized single particle tracking results bring out the interdependence of cholesterol and actin cytoskeleton in regulating diffusion of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews

Modulator Research Collaboration for Substance Use Disorders "Geneva, Switzerland, August 15, 2022 - Addex Therapeutics compounds for Charcot-Marie-Tooth type 1A neuropathy (CMT1A) and pain. " Read more at the source #DrGPCR #GPCR

"Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs targeting the intracellular allosteric binding site (IABS) of the CC chemokine receptor 2 (CCR2), a class A GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

describe production of the human A2A adenosine receptor (A2AAR), a class A G protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews