Search Results

conformation-selective probes for monitoring activation-induced changes in cellular environments (Irannejad, R. conformational changes for the binding to the same GPCR to mediate differential regulatory effects (Haider, R. various processes, and their imbalance is linked to pathological conditions, including cancer (Gros, R.

M., Medel-Lacruz, B., Baidya, M., Makarova, M., Mistry, R., Goulding, J., Drube, J., Hoffmann, C., Owen Cell, 186(10), 2238–2255.e20. https://doi.org/10.1016/j.cell.2023.04.018 Janetzko, J., Kise, R., Barsi-Rhyne

Career opportunities:  Senior Scientist, Phage Display | Manager, CMC Management | Translational R&D

responsiveness of canonical G protein–coupled chemokine receptors that bind to the same ligand(s) (R. Wang et al. 2009; R. J.

R., ... & Manglik, A. (2024).

and startup environments Read Maria Majellaro's Full Recap ➤ Lab Leadership Without Ego: A Model for R&

to do: bring four decades of frontline discovery insight straight to discovery-phase scientists and R&

Every R&D team is under the same pressure: deliver validated targets, clean pharmacology, and translatable

unspecific binding measurement (specific binding measured using CP55490 at 10 μM concentration ) (b) CB 2 R

Receives US$10 Million from AbbVie as Collaboration Targeting Neurological Diseases Achieves First R&

Sridharan R, Zuber J, Connelly SM, Mathew E, Dumont ME.

Wickner, W., and R. Schekman. 2008. Membrane fusion. Nat. Struct. Mol. Biol. 15:658–664.

GPCR Binders, Drugs, and more Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist

drug binds at two distinct sites of a human bitter taste GPCR Lior Peri ,  Donna Matzov ,  Dominic R

(Cold Spring Harbor Laboratory) . https://doi.org/10.1101/2024.04.17.590000 Pines, G., Fankhauser, R.

Janicot, R., et al., Direct interrogation of context-dependent GPCR activity with a universal biosensor

Releases First Protein Structures in PDB, Advances Lupus Therapy Research Structure Therapeutics Receives R&

This week's highlight includes congrats to: Madison Walker , Benjamin Myers , et al., for their research

antigen receptor T cell therapy could also be a way to target tumor cells expressing ectopic ORs (Naressi R.

Qian, Y., Ma, Z., Liu, C., Li, X., Zhu, X., Wang, N., Xu, Z., Xia, R., Liang, J., Duan, Y., Yin, H.,

structural insights into the 5-HT2C receptor as a therapeutic target for substance use disorders Leigh Walker