November 2022 Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer physiological processes, these activities are also involved in the onset and progression of various cancers primary emphasis on the signaling processes which underlie the mechanism of β-arrestins in the onset of cancer processes has important implications for understanding the therapeutic intervention and treatment of cancer

Eric Trinquet, Director of Research and Development at Revvity.   A GPCR Internalization Tool Designed for Real Research Needs Built on more than two decade A GPCR Internalization Tool Designed for Real Research Needs s of GPCR assay innovation , pHSense™  was developed to overcome GPCR  is a global nonprofit platform advancing GPCR research  through education, community, and platform Its GPCR research tools  support discovery teams and academic labs with precision reagents and validated

GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud to welcome Celtarys Research to its partner ecosystem. Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology , CEO of Celtarys Research. About Celtarys Research Celtarys Research is a biotech company based in Spain that specializes in the

September 2022 Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin Signalling and Migration "Kisspeptin is an anti-metastatic mediator in many cancer types, acting through However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic In KISS1R overexpressing triple-negative breast cancer (TNBC) cells, stimulation has been associated

receptor activity-modifying proteins Nicholas Kapolka , Geoffrey Taghon , and Daniel Isom  for their research protein-coupled receptor-mediated signaling of immunomodulation in tumor progression Methods & Updates in GPCR Research Clinical Pharmacology GPCR Jobs NEW Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research

occurring Δ9-tetrahydrocannabinolderivatives to cannabinoid CB1 and CB2 receptors, Pharmacological Research

in autism spectrum disorders GPCRs in Oncology and Immunology Molecular characterization of breast cancer 2023 Half Year And Second Quarter Financial Results And Provides Corporate Update Sosei Heptares and Cancer Research UK Announce the Dosing of the First Patient in a Phase I/IIa Trial with Cancer Immunotherapy GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024) GPCR Jobs NEW Postdoctoral Fellow NEW Research Laboratory Specialist Associate NEW Postdoc Research Associate Director, Regulatory Affairs Research

September 2022 Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer adenocarcinoma (PDAC) remains an aggressive disease that is expected to become the second cause of cancer -mediated knockdown of YES1 and transfection of epitogue-tagged YAP mutants in PANC-1 and MiaPaCa-2 cancer

Celtarys Research Joins Dr. GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. Full Breakdown of the Latest in GPCR Research Want detailed insights? Dive into this week’s research, tools, and biotech updates all in one place.

In a recent study on TAAR1, a GPCR linked to central nervous system disorders, researchers compared the

This is Lucía from the Celtarys Research chemistry team.  For our very first post in this ecosystem, we wanted to highlight a huge part of our work at Celtarys Research

Embark on another exciting exploration of the unknown realms of GPCR research. The 11th Adhesion GPCR Workshop 2024 was a successful event that brought together experts, researchers Biology - Tectonic Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research promotes transepithelial dendrite formation in human intestinal dendritic cells Methods & Updates in GPCR Research

Thus, developing assays for commercially available probes such as CELT-419 would facilitate research For example, a Cy5-labelled fluorescent ligand with the same pharmacophore is available from Celtarys Research development of measurement methods can increase the quality and quantity of both fundamental receptor research

September 2022 Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Here, we report that the Ovarian Cancer G-Protein Coupled Receptor1 (OGR1 or GPR68) has dual roles in

Vladimir Katanaev and colleagues identified compromised GPCR signaling in cancer cells using improved MRGPRX1 Improved approaches to channel capacity estimation discover compromised GPCR signaling in diverse cancer activation PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer Research UK announce first patient dosed with oral immunotherapy drug Trevena Reports Second Quarter Associate Protein Science Postdoctoral Fellow Research Laboratory Specialist Associate Postdoc Research

The GPCR ship is setting sail on a grand voyage across the vast ocean of research. Symposia 💲 Discounted GPCR courses GPCR Forum Start an engaging discussion or request help in your research Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research hepatocellular carcinoma cells via inhibition of the c-Jun N-terminal kinase Methods & Updates in GPCR Research

Summit 💲 Special Pricing on GPCR courses GPCR Forum Start a lively chat or request help with your research Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration Methods & Updates in GPCR Research

Despite their immense potential, utilizing FRET and BRET sensors in GPCR research comes with challenges In conclusion, FRET and BRET-based sensors have transformed the landscape of GPCR research, offering

Upregulated in Hepatocellular Carcinoma "Hepatocellular carcinoma (HCC) is at the forefront of the global cancer , with some members of the RGS family being associated with liver cancer as well. Considering this, we investigated the role of RGS20 as a potential prognostic marker in 28 different cancer By using the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data, our analysis revealed Our analysis further supports the putative function of RGS proteins, particularly RGS20, in cancer."

Hello GPCR Trailblazers, This week, we’re spotlighting Celtarys Research, our newest partner, featured GPCR will help researchers move faster with custom fluorescent ligands, translational insight, and tool-enabled Introducing Celtarys - Probe Development via Conjugation Strategies   Celtarys Research's first article Explore this week’s research, tools, and biotech insights in one place. The insights are ready.

Watch Episode 170 What We’re Missing in Pain Research In GPCR drug discovery, receptors typically steal against chronic pain. ___________ Keyword Cloud: RGS4 , GPCR data platform , GPCR training program , pain research

In the realm of molecular research, precise interpretation is crucial; a misread curve can lead to lost treatment race between Eli Lilly and Novo Upcoming events:  September GPCR symposia across Europe, UK

Learning the Lab, Learning Herself During her time at the contract research organization (CRO) in Ann She finally understood what it meant to be driven by a research question, not just assigned to one. For the first time, she saw herself as a future researcher, not just a technician or a student. Technical discipline is transferable—even across research cultures. The Importance of Passion in Research Catherine's journey highlights the importance of passion in research

Watch Episode 172 The Bigger Picture: GPCR Science Meets Public Health At its core, Catherine Demery’s research street-level contamination rising faster than medicine can adapt, Catherine’s work shows why overdose research Catherine’s research confronts this problem head-on by asking: What actually happens to breathing when From Street Samples to Lab Models What makes Catherine’s research particularly powerful is how it stays Without research that keeps pace, clinical tools will always be one step behind.

March 2022 ERNEST has established an Emergency Fund for Ukrainian researchers. "General Eligibility Researchers affiliated to any legal entity in Ukraine (for example, schools and universities, research centers, governmental institutions, or private companies) Deadlines Start of the October 2022 SHORT-TERM SCIENTIFIC MISSIONS (STSM) We offer short-term scientific mission grants to Ukrainian Our scientific perspective is broad, and we are happy to consider any research proposals from those in

December 2021 "Meet Peter McNamara, Ph.D., Tectonic’s SVP, Head of Research.

June 2022 "CRN04894 Selected for Oral Presentation SAN DIEGO, June 8, 2022 — Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX), announced that results from the company’s Phase 1 study of CRN04894, the company’s investigational candidate for the treatment of Cushing’s disease, congenital adrenal hyperplasia (CAH) and other conditions driven by excess adrenocorticotropic hormone (ACTH), were selected for an oral presentation at ENDO 2022, the Endocrine Society’s annual meeting. Crinetics recently reported that administration of CRN04894 reduced both serum cortisol levels and 24-hour urine free cortisol excretion in the presence of sustained, disease-like ACTH concentrations in multiple-ascending dose cohorts of a Phase 1 study." Read more at the source #DrGPCR #GPCR #IndustryNews

However, the role of β2-AR in oral cancer is not well identified.

October 2022 β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells "β-arrestins mediate regulatory processes for over 800 different G protein-coupled receptors (GPCRs) by adopting specific conformations that result from the geometry of the GPCR-β-arrestin complex. However, whether β-arrestin1 and 2 respond differently for binding to the same GPCR is still unknown. Employing GRK knockout cells and β-arrestins lacking the finger-loop-region, we show that the two isoforms prefer to associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging" and "core"). Furthermore, the utilisation of advanced NanoLuc/FlAsH-based biosensors reveals distinct conformational signatures of β-arrestin1 and 2 when bound to active PTH1R (P-R*). Moreover, we assess β-arrestin conformational changes that are induced specifically by proximal and distal C-terminal phosphorylation and in the absence of GPCR kinases (GRKs) (R*). Here, we show differences between conformational changes that are induced by P-R* or R* receptor states and further disclose the impact of site-specific GPCR phosphorylation on arrestin-coupling and function." Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter

GPCR, a nonprofit organization serving the global G protein-coupled receptor (GPCR) research community This partnership exists to bring that conversation into the open, and to invite GPCR researchers to be Researchers working on GPCR targets are invited to request free samples through the Dr. Thorough validation and engagement with the GPCR researcher community are both essential for realizing For the GPCR research community, the relevance of this partnership extends beyond individual reagents