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Currently, the exact function of the C5aR2 is actively debated in the context of C5aR1, even though both

Chronic human HF is characterized by several important neurohormonal perturbations, emanating from both

therapeutic window ✅ Examples of how rebinding in dense receptor environments  amplifies target occupancy, even

a ligand binds (k₁) and how long it stays bound (k₂)  can alter therapeutic profiles dramatically, even

NHS esters are not very stable even in aqueous environment but they only need a slightly basic medium

Ligands may take hours to equilibrate , even when they look potent on paper.

your science isn't continuously integrated with your GPCR operational strategy and investment goals, even

We've got 11 GPCR papers, seven industry news pieces, a new GPCR event, and even a job ad.  

Surprisingly, this interaction did not result in G12 activation, even in the presence of GTP, which is

But Terry Kenakin’s new Emerging Drug Hunter lecture reveals why this assumption can mislead even experienced

The gravity of this regulation becomes even more apparent when we consider the potential consequences

Some studies have also reported GPR84 involvement in pain, atherosclerosis, and even metabolic disorders

At Celtarys, we focus on developing fluorescent tools that keep minimal background signal even without

the wrong interpretation of antagonist behavior can derail your conclusions, your experiments, and even

And here's something even better: the video versions of our podcast episodes are now available to the

absence of G proteins (Gether 2000), with numerous intermediate sub-states in between (Vauquelin and Van and can differ in intrinsic efficacy; 2) partial agonists are incapable of inducing maximal activity even

In addition, tyrosine sulfation is heterogenous between cell lines or even on the same cell (Scurci I

Baek et al., 2021) allow the prediction of the 3D structure of a protein from the amino acid sequence even

US28 evolved high constitutive activity to evade host immunity, whereas ACKR3 functions as a homeostatic

validation, a larger range of compounds will be tested, including screening chemical libraries with even 999. (12)      Martín-Fontecha, M.; Angelina, A.; Rückert, B.; Rueda-Zubiaurre, A.; Martín-Cruz, L.; Van , S.; Beck, J.; Nettekoven, M.; Benito-Cuesta, I.; Grande, T.; Drawnel, F.; Widmer, G.; Holzer, D.; Van V.; Van Der Stelt, M.; Pacher, P.; Gertsch, J.; Ullmer, C.; McCormick, P. J.; Oddi, S.; Spaink, H.