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Alejandra Tomas, et al. for their research on Engineered mini-G proteins block the internalization of agonism The roles of RGS proteins in cardiometabolic disease GPCR Binders, Drugs, and more Engineered mini-G

NanoBRET ligand binding [5]), effector protein recruitment assays (e.g G protein recruitment assay [6], mini-G Wan, Q., et al., Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells. 

Pc(4-4), a lead backbone cyclic peptide, was selected out of a mini-library, directed toward PAR2&4 PH-binding

Brilliant minds doing low impact work is not a strategy. It’s a slow-motion car crash.

These mini "journal clubs" kept me informed about the latest research and sharpened my critical thinking

The fission yeast Schizosaccharomyces pombe has two mating types, Plus (P) and Minus (M).

In the run-up to the conference, our founder Yamina Berchiche is speaking with some of the brilliant minds

more Tri-part NanoLuc as a new split technology with potential applications in chemical biology: a mini-review

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Hey there, curious minds! Want to know what’s buzzing in the world of GPCRs?  This Week’s Highlights: Harnessing Deep Mutational Scanning for Enhanced Drug Discovery Cam Sinh Lu

approved for first-line treatment The Lundbeck Foundation is awarding DKK 174 million in grants to seven ‘mind-bending

Why contribute: Join a global, like-minded GPCR community.

Hi there GPCR minds! Join us for a deep dive into the world of GPCRs. This week's highlights: Dr.

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with decitabine in relapsed or refractory acute myeloid leukemia Methods & Updates in GPCR Research Mining

Get ready to dive into some discoveries and mind-blowing breakthroughs with us! This Week’s Highlights: Congrats to: Our contributor, Cam Sinh Lu ,  who has just released an incredible with his team: Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR China M Payne ,   Cam Sinh

With this in mind one of the proposals is to take advantage of biased agonism, i.e. when the same receptor

After 90 min (indicated with an arrow), the measurement was paused, and dissociation was initiated by BBV/well (CD3R = 0.7 nM), and different concentrations of corresponding dopaminergic ligands for 180 min well) were incubated with 1 nM CELT-419 and different concentrations of Dopamine or Spiperone for 180 min Side Effects of a Dopamine Agonist Therapy for Parkinson’s Disease: A Mini-Review of Clinical Pharmacology R.; Min, M.; Kopanchuk, S.; Rinken, A.