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🌟The Dr. GPCR event of the year is the 3rd edition of the Summit. Become a Dr. GPCR Ecosystem site member to attend the Summit, it’s free!

the kinetic factors that enhance in vivo efficacy beyond traditional potency metrics, as presented by Dr Dr. That's exactly what Dr. Dr. Submit your paper today to secure your work in Volume II ➤ Why Dr.

⚠️Mark your calendar for the Dr. GPCR Summit 2022 held between Oct. 10 - 16, it's FREE!

. 🔍 This Week in Dr. This week, Dr. Featured Talk: Dr. Terry Kenakin on The Kinetics of Allostery . Secure your seat today ➤ Why Dr. Read the Premium edition here ➤ What our members say 🗣️ "Dr.

📅 Our FREE Dr. GPCR Summit 2022 is less than a month away!

forward Meet both the global biotech community and Boston’s local innovators in one room Be part of Dr Be Part of the GPCR Community Dr.

Join Dr. GPCR Is in This Conversation At Dr. Here’s who we've talked to so far: 🎥 Interview with Dr.   📚 Terry’s Corner — The Only On-Demand Pharmacology Hub with Dr. Kenakin Himself If you’re part of the Dr.

July 2022 "I’m happy to share that I’m starting a new position as Scientific co-founder LASEREDD Therapeutics" Ross Bathgate Read more at the source #DrGPCR #GPCR #IndustryNews

A Broader Lens: Dr. GPCR As the co-founder of Dr.

June 2022 "We’re delighted to welcome Dr Ed Brennan as our new Vice President, Head of Clinical Development Dr Brennan has extensive experience across all phases of clinical development, and across multiple therapeutic

Tomorrow is the day for another Dr. GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

November 2021 Read more at the source #DrGPCR #GPCR #IndustryNews

Dr. Register and join your colleagues in September ➤ Why Dr. GPCR Premium Membership Gives You an Edge In a world filled with noise, Dr. ” - DrGPCR University Course Attendee Get a competitive advantage—Join Dr.

Excited to hear Dr. Register here (FREE) https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe #drgpcr #gpcr #virtualcafe

Excited to hear Dr. automated micro-plate-based methods for quantifying #GPCR activation. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe

Come attend this month's virtual café talk to see the awesome work of Dr. Register here (FREE) https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

November 2021 "So proud and grateful to receive honorary doctorate yesterday from Karolinska Institute and celebrate with my family in Stockholm." Read more at the source #DrGPCR #GPCR #IndustryNews

Join us and learn how to quantify your kinetic GPCR signaling from the expert himself: Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

Be sure to signup for the next Virtual Cafe of Dr. GPCR on the 24th of June! This time, the GPCRdb team ( Dr. David Gloriam , Dr. Reserve your spot for free at: https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #GPCR #GPCRs #DrGPCR

April 2022 Read more at the source #DrGPCR #GPCR #IndustryNews

Join us for a fantastic introduction to GPCRdb with Dr. David Gloriam and Dr. Albert Kooistra. Register today: https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

Did you register for our next Dr. GPCR Virtual Cafe? Register today! Addgene's Dr. research or you want to share your materials, this is the place to go. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe

Join us for the first virtual cafe talk to hear about the amazing work that Dr. Brian Arey is doing. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas naloxone, with only slight structural changes compared to morphine, exhibits inhibitory effect, and is used to treat opioid abuse. The mechanism by which the MOR distinguishes between the two is unclear. Molecular dynamics (MD) simulations on a 1-μs time scale and metadynamics-enhanced conformational sampling are used here to determine the different interactions of these two ligands with MOR: morphine adjusted its pose by continuously flipping deeper into the pocket, whereas naloxone failed to penetrate deeper because its allyl group conflicts with several residues of MOR. The endogenous peptide ligand endomorphin-1 (EM-1) underwent almost no significant conformational changes during the MD simulations. To validate these processes, we employed GIRK4S143T, a MOR-activated Gβγ-protein effector, in combination with mutagenesis and electrophysiological recordings. We verified the role of some key residues in the dynamic recognition of naloxone and morphine and identified the key residue I322, which leads to differential recognition of morphine and naloxone while assisting EM-1 in activating MOR. Reducing the side chain size of I322 (MORI322A) transformed naloxone from an inhibitor directly into an agonist of MOR, and I322A also significantly attenuated the potency of MOR on EM-1, confirming that binding deep in the pocket is critical for the agonistic effect of MOR. This finding reveals a dynamic mechanism for the response of MOR to different ligands and provides a basis for the discovery of new ligands for MOR at the atomic level." Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR University Get ready for our next Dr. GPCR University hands-on workshop with Dr.  Hoare and Dr. GPCR Complementary one-year Dr. Dr. GPCR Symposia With a premium membership, you can watch on-demand the Dr. Dr. Let’s dive into the Classified GPCR News from March 25th to March 31st, 2024 GPCR Activation and Signaling

Additionally, we are having a Panel Discussion on Publishing in Academia with Drs. Dr. GPCR University Save the date for our upcoming workshop starting May 9th, 2024, featuring Dr. Gain invaluable skills in data analysis under Dr. Hoare's expert guidance. Dr. Terry Kenakin's "Applying Pharmacology to Drug Discovery" course at Dr. Dr.

work on Direct interrogation of context-dependent GPCR activity with a universal biosensor platform Dr Dr. GPCR University Save the date for our upcoming workshop, starting May 9th, 2024, featuring Dr.  Under Dr. Hoare's expert guidance, you will gain invaluable skills in data analysis. Dr. Terry Kenakin's "Applying Pharmacology to Drug Discovery" course at Dr. Dr.

This week's highlight includes congrats to: Drs.  Dr. GPCR Symposia With a premium membership, you can watch on-demand the Dr. Dr. Let’s dive into the Classified GPCR News from March 18th to 24th, 2024 GPCR Activation and Signaling Behavior Director of Laboratory Operations - Single-molecule Imaging Center Scientific Assistant Join Dr

This week's highlight includes congrats to: Christina Katharina Kuhn, Drs. Howard Rockman, and Dr.  We are delighted to confirm the participation of esteemed speakers such as Drs.  Dr. GPCR University Great News! The Dr. Dr.

Hello Readers👋, We're excited to have you in the Dr. GPCR Ecosystem. For Dr. GPCR News, subscribe to our monthly newsletter. This month on the Dr. GPCR News video edition, we chatted with Dr. Oliver Hartley. Ends tomorrow - March 31st, 2023. Explore Dr. GPCR Ecosystem