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GPCR signaling wasn’t linear. It wasn’t clean. what they weren’t built for, JB’s group engineered fluorescent ligands based on known GLP-1 and GIP pharmacology Why GPCR Collaboration Is Essential for Modern Science Hodson makes the point bluntly: modern GPCR science Together, they push GPCR science faster. They’re team problems — the kind that require chemistry, physiology, pharmacology, structural biology

We’ve made some updates to the Principles of Pharmacology I & II courses, and we can’t wait for you Here’s the refreshed schedule: Principles of Pharmacology I October 3, 10, 17, 24 Principles of Pharmacology Don’t miss out on insightful resources like '   Applying Pharmacology to Drug Discovery ' and ' Advanced Data Analysis for GPCR Pharmacology .' Don’t miss your chance to dive into the Principles of Pharmacology I & II BUNDLE .

s latest lecture delivers high-impact insight crafted for teams navigating the complex behaviors of GPCR-targeting As Kenakin explains, all GPCR signaling is allosteric , and pretending otherwise introduces risk at every Terry’s Pharmacology Corner  delivers trusted, razor-sharp insight to help drug discovery professionals Unlock “GPCRs as Allosteric Machines” Now Only in Terry’s Corner Why Terry’s Corner Terry’s Pharmacology Corner  is your trusted, expert-led guide through the evolving landscape of GPCR science.

Apply unique pharmacologic assays and unconventional ligands to unveil GPCR activities. pharmacology concepts for practical use in academia and industry. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Summit Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs HIGHLIGHT Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc

Terry's Corner - The Truth About Allosteric Displacement Allosteric binding isn’t just a twist in the pharmacology Read the article now ➤ Discovery on Target - The Next Wave of GPCR Drug Discovery The 20th Annual GPCR-Based GPCR Premium Membership Gives You an Edge The GPCR field is advancing at breakneck speed. GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need The pace of GPCR innovation is accelerating.

Binding Sites and Their Ligandability Potential Today, we started the Principles of Pharmacology II Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already Exploit probe dependence to shape precision pharmacology.  Want to avoid off-target effects? GPCR Podcast Listener Why Dr. If you work on GPCRs across translational pharmacology, drug development, or molecular pharmacology, GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who

The central role of GPCRs in Neurological Disorders GPCRs are the largest family of membrane receptors Over 30% of FDA-approved drugs target GPCRs, with many targeting CNS located GPCRs. GPCR Structure, Activation, and Signaling Pathways in the Brain An understanding of GPCR structure is GPCR signaling: (A) an orthosteric ligand (orange) binds an inactive GPCR, the β2 adrenergic receptor Emerging GPCR Therapeutic Targets in CNS Drug Discovery GPCRs have been studied for decades, but there

Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates See the true  pharmacology:  Lower sensitivity to uncover partial agonism and compare relative efficacy classified industry updates, priority event alerts, vetted jobs, and commentary that connects dots across pharmacology GPCR scientists, translational pharmacologists, discovery teams, and decision-makers who need fast, curated GPCR innovation is accelerating.

with pharmacological rigor. That opened the door to something rare in functional pharmacology: plate-based GPCR internalization tracking internalization of endogenous GLP-1 receptors in rat beta cells—with no overexpression, no imaging, and no pharmacological GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

Are you ready to truly understand how pharmacologists predict whole-body drug response from a single straight to it:   Why models are vital for translating lab data into clinical forecasts The 4 types of pharmacologic GPCR News.   Elevate your pharmacology expertise. Unlock "Pharmacologic Models" now

For decades, GPCRs have been the cornerstone of pharmacology. Projects in his group often begin with either: A new GPCR structure  ripe for exploration, or A pharmacological Carlsson’s group integrates modeling with mechanistic pharmacology. , and scalable experimental assays is shrinking the gap between modeling and pharmacology. Forward The Carlsson lab exemplifies how c omputational biochemistry can meaningfully impact real-world pharmacology

Upcoming events:  GPCR-TDD Europe; Pharmacology 2026. Researchers navigating complex datasets, balancing innovation with assay rigor, or working across chemistry–pharmacology–physiology GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need GPCR innovation is accelerating. GPCR Team

Pharmacology isn’t only about ligands, receptors, and downstream G protein signaling—it’s also about The Hidden Lever in GPCR Research In GPCR pharmacology, the conversation often centers on ligand properties—affinity Clarify whether observed effects reflect true pharmacology or assay artifacts . From Bench Insight to Strategic Advantage Terry Kenakin’s decades of pharmacology leadership converge A growing on-demand library  of expert pharmacology lessons to revisit anytime.

His work spans deep academic research, startup life, and the application of machine learning and pharmacology to GPCR drug discovery. Superluminal Medicines: AI/ML Meets GPCR Pharmacology As Ajay continued to explore how GPCR signaling Despite decades of progress in structural biology and pharmacology, predicting how  a GPCR will respond Takeaway: Ajay Yekkirala’s story is not just about GPCR science or startup success.

Sudarshan Rajagopal and their lab team study on 'Location bias: A "Hidden Variable" in GPCR pharmacology GPCR Symposium on 'GPCRs as Therapeutic Modalities'. , and more Key Aspects of Modern GPCR Drug Discovery Location bias: A "Hidden Variable" in GPCR pharmacology Postdoc Research Associate Director, Regulatory Affairs Research Scientist/Senior Scientist I - Molecular Pharmacology GPCR Ecosystem

GPCR , the global nonprofit platform dedicated to advancing GPCR science through education, community GPCR Ecosystem. GPCR Podcast To mark the spotlight, Dr. GPCR  invited Dr. Eric Trinquet  to the Dr. GPCR. GPCR Dr.

One of its first pillars, Terry’s Pharmacology Corner , led by Dr. Through Terry’s Pharmacology Corner , he shares decades of expertise in an accessible, on-demand format Terry Kenakin , a pioneer who helped shape modern pharmacology and deepen our understanding of GPCR function GPCR About Dr. GPCR Dr. Related Links 🔗 Explore Terry’s Pharmacology Corner → TerryKenakin.com 📧 Connect with us →   Hello@

of Pharmacology I course! Don’t miss this opportunity to advance your knowledge and skills in pharmacology! pharmacology and apply it to their research in academia and industry. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and GPCR Jobs HIGHLIGHT Research Associate - Professor Graeme Milligan HIGHLIGHT Postdoc in Molecular Pharmacology

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

partnership built on trust and curiosity — reshaped both careers and helped unlock a new generation of GPCR How a Collaboration Led to a GPCR Imaging Breakthrough JB didn’t set out to contribute to a GPCR imaging It was the start of a scientific partnership with the potential to shift how GPCRs could be visualized How Chemical Probes Transformed GPCR Imaging and Outperformed Antibodies As JB continued exploring the Designing Reliable GPCR Imaging Tools for Real Biological Systems Success brought new challenges.

In the high-stakes world of GPCR drug discovery , breakthrough science isn't enough. GPCR, we recognized this core problem. This is the essence of de-risking GPCR programs through operational excellence. the entire GPCR program as a single, interconnected entity. The GPCR Precision Blueprint is more than a concept.

Interdisciplinary design isn’t optional in GPCR imaging. It’s the catalyst. And the most striking validation came from in vivo GPCR imaging. They unlocked pharmacologically relevant insights that were previously inaccessible. Strong GPCR imaging tools come from strong interdisciplinary relationships.  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization

GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing discovery and translational pharmacology. GPCR scientists, translational pharmacologists, biotech discovery teams, platform company leaders, and Access this week’s full Premium Edition here ➤ What our members say 🗣️ "The best pharmacology teacher Also super-valuable for those of us learning how to teach pharmacology." — DrGPCR University Attendee

Broichhagen aka JB, the goal was bold and elegant: Create a photo-switchable ligand to remotely control GPCR They had a tool that did bind the GPCR… but not in the light-controlled way they wanted. The Moment a Failed Tool Became a GPCR Imaging Breakthrough What the compound did reliably do was label This solved a long-standing problem in GPCR biology: You can't understand signaling if you can’t see  The Larger Lesson for Scientists and Innovators This story isn’t just about a GPCR imaging tool.

biology and pharmacology Dr. Materials Access to the private group Certificate of participation Learn the essentials: Measuring the pharmacologic synthetic biology for human G protein-coupled receptor biology and pharmacology Industry News Muscarinic - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW Postdoc in GPCR mechanosensing GPCR Ecosystem

agricultural settings inspired him to train in veterinary medicine, where he was introduced to physiology and pharmacology GPCRs Re-Enter the Story — Not as Theory, but as Tools GPCRs have always been powerful drug targets — That partnership eventually produced fluorescent GPCR tools  that allow researchers to visualize GPCR Emerging direction: Multi-target GPCR + myostatin-pathway combinations. Can GPCRs act as “delivery ZIP codes” for targeted therapies?

Recent advances in structural biology and pharmacology have revealed the existence of allosteric sites within GPCRs' intracellular domains. Allosteric modulators targeting GPCRs can display one or more of the following pharmacological characteristics GPCR activity, enabling greater specificity and fewer side effects. their allosteric influence, an attribute that offers a considerable degree of adjustability in terms of pharmacological

explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." GPCRs in the Background, But Always Present Even though his primary focus wasn’t GPCRs themselves, Serafini the core mediator  — demonstrating the reach of these signaling pathways beyond classical receptor pharmacology Takeaway Forget what you think you know about GPCR drug targets.