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We have gathered 24 new research papers on GPCRs and updates on industry news related to GPCRs. Bryan Roth and Brian Krumm for their study on Molecular glues as potential GPCR therapeutics Drs. breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects GPR56: A potential therapeutic GPCR therapeutics A high-affinity, cis-on photoswitchable beta blocker to optically control β2-adrenergic GPCR Ecosystem

Enhance your GPCR research with deeper assay insights for more effective results. This Week’s GPCR Intelligence: If you want cleaner decisions, start with the system—then the ligand. Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates allosteric site on an orphan GPCR. 🔍 This Week in Dr. GPCR innovation is accelerating.

Before your GPCR ligand ever meets its receptor, it meets the enzymes that determine whether it survives Even the most elegant GPCR ligand can fail if it never reaches its receptor. These nuances define therapeutic potential and side-effect risk. Each mode reshapes both potency and therapeutic window. Kenakin with your own enzyme or GPCR interaction puzzles.

Watch Episode 175 From failed assays to breakthroughs in GPCR modeling , Dr. At that point, very few GPCR crystal structures had been determined. For Carlsson, this marked a shift in how his lab approached GPCR research. He came to see that effective GPCR research requires true interdisciplinary integration. those who can unite modeling with experimentation, turning predictions into real therapeutic breakthroughs

Eric Trinquet, a veteran innovator behind functional GPCR assays like HTRF and IP-One, believes rigid If you’re building tools or careers in GPCR science, this is your playbook. It began with an unmet need: how to track Gq-coupled GPCR activity without the mess of calcium flux or GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

Listen to the episode ➤ Quick Links Assess GPCR Biased Signaling of Agonist How GPCR Collaboration Built an Innovation Engine From Pipettes to Platforms: The Evolution of GPCR Research How GPCR Spatial Signaling GPCR Premium Membership Gives You an Edge Premium delivers a clear, noise-free stream of GPCR intelligence GPCR innovation is accelerating. GPCR Team

Hello GPCR people! Check out our GPCR roundup now, and be the first to read! This week's highlight: Congrats to our partner GPCR Therapeutics, on their expansion into fibrosis with selectivity Industry News Sosei Heptares and Verily Nominate First G-protein-coupled receptor Target for Therapeutic Therapeutics Expands Pipeline into Fibrosis with a Combination Approach Targeting LPA1 GPCR Events, GPCR Ecosystem

But for Ajay Yekkirala, that closed door lit the fuse for a career that would reimagine GPCR therapeutics therapeutics. therapeutics. Blue Therapeutics: Turning GPCR Biology Into a Business Ajay’s academic training planted the seeds for therapeutics.

GPCR , the global nonprofit platform dedicated to advancing GPCR science through education, community GPCR Ecosystem. GPCR Podcast To mark the spotlight, Dr. GPCR  invited Dr. Eric Trinquet  to the Dr. GPCR. GPCR Dr.

Hi there GPCR minds! Join us for a deep dive into the world of GPCRs. This week's highlight: Congratulations to the GPCR Therapeutics team for their publication on improving GPCR Symposium for the year on GPCRs in Immunology and Oncology! Therapeutics Announces Publication on Improving Hematopoietic Stem Cell Mobilization Using Propranolol Progress Parker Moss to Join Exscientia as EVP, Corporate Development Confo Therapeutics Nominated for

GPCR. Dear Dr. GPCR, it was with a simple goal: to connect people who shared a passion for GPCR science and discovery GPCR Foundry  — our R&D and biotech hub designed to bridge GPCR science with execution. The Dr. GPCR resources, connect new scientists, and earn rewards  for helping expand access to GPCR knowledge GPCR About Dr. GPCR Dr.

partnership built on trust and curiosity — reshaped both careers and helped unlock a new generation of GPCR How a Collaboration Led to a GPCR Imaging Breakthrough JB didn’t set out to contribute to a GPCR imaging It was the start of a scientific partnership with the potential to shift how GPCRs could be visualized How Chemical Probes Transformed GPCR Imaging and Outperformed Antibodies As JB continued exploring the Designing Reliable GPCR Imaging Tools for Real Biological Systems Success brought new challenges.

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

In the high-stakes world of GPCR drug discovery , breakthrough science isn't enough. GPCR, we recognized this core problem. This is the essence of de-risking GPCR programs through operational excellence. the entire GPCR program as a single, interconnected entity. The GPCR Precision Blueprint is more than a concept.

Why Speed Matters in GPCR Drug Discovery Nine out of ten GPCR programs stall  not because the target In accelerating GPCR drug discovery, the bottleneck isn’t target identification — it’s turning validated “GPCRs are nature’s prototype allosteric proteins. Everything they do is allosteric.” Antibodies, Bias, and the Expanding Modality Landscape Antibody therapeutics are now entering spaces Kenakin with your own enzyme or GPCR interaction puzzles.

A single successful GPCR imaging experiment can transform a project’s trajectory. Interdisciplinary design isn’t optional in GPCR imaging. It’s the catalyst. And the most striking validation came from in vivo GPCR imaging. Strong GPCR imaging tools come from strong interdisciplinary relationships.  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization

July 2022 Confo Therapeutics receives €1.7 million VLAIO grant for further research on GPCR modulators for rare diseases "29/06/2022 Confo Therapeutics, founded in 2015 as a spin-off from VIB and VUB, announced The grant should help expand Confo Therapeutic’s research on G protein-coupled receptor (GPCR) drug candidates . " Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

Strategies for Targeted Therapeutics. GPCR-Based Drug Discovery conference is where the future of GPCR therapies will be defined. GPCR Premium Membership Gives You an Edge In a world filled with noise, Dr. GPCR Premium Membership delivers curated, noise-free intelligence every week. The pace of GPCR innovation is accelerating.

Broichhagen aka JB, the goal was bold and elegant: Create a photo-switchable ligand to remotely control GPCR They had a tool that did bind the GPCR… but not in the light-controlled way they wanted. not just the pancreas This tool helped clarify: Which neurons respond Which cell populations drive therapeutic The Larger Lesson for Scientists and Innovators This story isn’t just about a GPCR imaging tool. metabolic therapy Guide how next-generation incretin drugs are designed Support cell-targeted conjugate therapeutic

Hello GPCR people! Check out our GPCR roundup now, and be the first to read! Kevin Wright on his new position as Director of Targeted and Immuno-oncology at GPCR Therapeutics, our GPCR Symposium on 'GPCRs as Therapeutic Modalities' with Richa Tyagi, Dr. Terry Kenakin, Dr. Kevin Wright Joins GPCR Therapeutics as Director of Targeted and Immuno-oncology Sosei Heptares Adds Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

This week's highlights: Kudos to our partner, GPCR Therapeutics, for partnering with Bridge Biotherapeutics Therapeutics Announces Out-Licensing Agreement with Bridge Biotherapeutics in Idiopathic Pulmonary Fibrosis - Providing the next generation of high-impact medicines Structure Therapeutics Provides Comprehensive Study Neurocrine opening two Phase 1 trials in oral Parkinson’s therapies Bearing Fruit: Deep Apple Therapeutics Launches to Screen AI-Generated Virtual Libraries AbbVie to Acquire Cerevel Therapeutics in Transformative

Congrats to the GPCR Therapeutics team for their recent paper in the American College of Clinical Pharmacology GPCR Symposium on 'GPCRs as Therapeutic Modalities'. and oligomerization Molecular Insights into GPCR Mechanisms for Drugs of Abuse Industry News 'GPCR Therapeutics Events, Meetings, and Webinars NEW Antiverse: Reimagining Therapeutic Antibodies Using AI ONCORNET2.0 GPCR Ecosystem

Fluorescent probes illuminate the mysteries of GPCRs in cutting-edge research. Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing GPCR Premium: Sneak Peek A fast, editorial preview—enough to guide your attention, not replace your due Track, GPCR Happy Hour, and more! GPCR innovation is accelerating.

GPCR Partner, GPCR Therapeutics, for passing the Technology Evaluation process for listing on the KOSDAQ GPCR Symposium on Structural and Molecular Insights on GPCR Activation. GPCR Therapeutics passes the Technology Evaluation process for listing on KOSDAQ. " (June 28 - 30, 2023) FREE Seminar Antibodies targeting Membrane Proteins - From Antigen to New Therapeutics GPCR Ecosystem

We've got 11 GPCR papers, seven industry news pieces, a new GPCR event, and even a job ad.   for Drug Discovery DMS: Linking Protein Structure To Function AbbVie Completes Acquisition of Cerevel Therapeutics Nxera Pharma attended the Drug Discovery Ecosystem Summit Tectonic Therapeutic Announces Closing of Merger with AVROBIO as well as Concurrent Private Placement of $130.7 Million Tectonic Therapeutic Announces GPCR Ecosystem

his interview, Regulators of G protein Signaling (RGS proteins)  might hold some of the most untapped therapeutic explicitly interested in GPCR signaling... but the thing about GPCRs... is you always kind of end up landing at a GPCR as a major target." GPCRs in the Background, But Always Present Even though his primary focus wasn’t GPCRs themselves, Serafini Takeaway Forget what you think you know about GPCR drug targets.

GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud therapeutics. GPCR. accelerate the adoption of our chemical tools and foster collaborations that turn receptor biology into therapeutic GPCR Dr.

and Biophysical Society Meeting previews; positive ACCESS data for Structure Therapeutics’ oral GLP- Terry’s Corner: GPCR Binding Affinity Experiments That Hold Up Orthosteric GPCR binding affinity experiments GPCR Podcast: When GPCR Tools Scale Even the most elegant tools only matter when they scale beyond a GPCR offers a clear signal of where the field is heading. GPCR Premium Member And Lock in The Current Rate➤ https://www.ecosystem.drgpcr.com/gpcr-university-pricing

Exploring the Hidden Dynamics: How Kinetics Reveals What Equilibrium Conceals in GPCR Research. Hi GPCR Community, If equilibrium curves are your comfort zone, this week’s feature will challenge (and GPCR Premium: Sneak Peek Here’s a fast, high-level preview of what Premium Members are unpacking this We’ve got your GPCR Track, Happy Hour, and sessions mapped so you can extract maximum value. GPCR innovation is accelerating.