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Get ready for an expedition, GPCR explorers! Embark on another exciting exploration of the unknown realms of GPCR research. Welcome back to your weekly GPCR quest! Therapeutic Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc Research Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation

The central role of GPCRs in Neurological Disorders GPCRs are the largest family of membrane receptors Over 30% of FDA-approved drugs target GPCRs, with many targeting CNS located GPCRs. GPCR Structure, Activation, and Signaling Pathways in the Brain An understanding of GPCR structure is GPCR signaling: (A) an orthosteric ligand (orange) binds an inactive GPCR, the β2 adrenergic receptor More research into the endocannabinoid system (ECS) will let us access these GPCRs in a safer manner

Research; Lab-in-the-Loop Hit Discovery advances. Kenakin is a masterful teacher and communicator—and a leading expert in our field.” — Dr. unconventional path—from patient to scientist—exemplifies why personal mission matters in translational research Redefine your playbook:  Why Serafini believes that pain research needs to start from clinical phenotype s Corner  digital pharmacology courses Priority access to insights from major conferences, emerging research

s latest lecture delivers high-impact insight crafted for teams navigating the complex behaviors of GPCR-targeting As Kenakin explains, all GPCR signaling is allosteric , and pretending otherwise introduces risk at every If you’re still treating GPCRs as passive targets, your screening filters may be blind to key liabilities But without understanding how GPCR state changes  influence that affinity—or vice versa—drug discovery Corner  is your trusted, expert-led guide through the evolving landscape of GPCR science.

Discovering Modeling (and GPCRs) by Accident That interest led him to pursue a thesis at Scripps Research computational environment, and he realized how much he enjoyed the intellectual energy of modeling communities For Carlsson, this marked a shift in how his lab approached GPCR research. He came to see that effective GPCR research requires true interdisciplinary integration. Trainees must learn how to interpret assay data, understand pharmacological context, and communicate

Enhance your GPCR research with deeper assay insights for more effective results. Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates Plus: new research on CaSR, leptin signaling, and inflammation-linked GPCRs — and curated roles in computational Become a Premium Member today. ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, field 🧠 Designed for researchers at every career stage

to advance GPCR research worldwide. GPCR Ambassador Program As we grow, we want the community to grow with us. , and bringing more researchers into the community. Community and Connection Dr. GPCR isn’t just a digital platform — it’s a community. research, education, and community.

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August 2022 "GPCRs modulate a plethora of physiological processes and mediate the effects of one-third The guidelines will aid consistency and clarity, as the basic receptor research and drug discovery communities Read more at the source #DrGPCR #GPCR #IndustryNews

If you’re building tools or careers in GPCR science, this is your playbook. Changed After This Data: Trinquet pushed pHSense toward rapid commercialization—pivoting it from a research GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical tools to accelerate your research or career. 👥 Build connections. 🧪 Get insights. 🎧 Stay ahead.

That discipline—paying attention to the internal spark—became the foundation of his scientific communication Silence, by contrast, protects your ego but slows your research. In his collaboration with David Hodson, every major leap—from early ligand design to GPCR visualization conversation is part of a three episode series produced in collaboration with our partners at Celtarys Research  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization

Before your GPCR ligand ever meets its receptor, it meets the enzymes that determine whether it survives Discovery Program So what does that mean for discovery scientists designing the next generation of GPCR Even the most elegant GPCR ligand can fail if it never reaches its receptor. GPCR members save 50%+  with your Weekly News code. 👉 Join Terry’s Corner & Secure Your Spot for the Kenakin with your own enzyme or GPCR interaction puzzles.

July 2022 Confo Therapeutics receives €1.7 million VLAIO grant for further research on GPCR modulators The grant should help expand Confo Therapeutic’s research on G protein-coupled receptor (GPCR) drug candidates . " Read more at the source #DrGPCR #GPCR #IndustryNews

How a Collaboration Led to a GPCR Imaging Breakthrough JB didn’t set out to contribute to a GPCR imaging Designing Reliable GPCR Imaging Tools for Real Biological Systems Success brought new challenges. research challenging. capture receptor dynamics in intact tissue and live animals, expanding what’s possible in both basic research conversation is part of a three episode series produced in collaboration with our partners at Celtarys Research

Before the advent of AlphaFold, homology modeling was the most common method for predicting G protein-coupled receptor (GPCR) structures, especially when experimental data were limited. GPCRs are dynamic, switching between multiple conformations, and many have only distant homologs with The introduction of AlphaFold2 marked a major advancement in the field of GPCR structure prediction. In a recent study on TAAR1, a GPCR linked to central nervous system disorders, researchers compared the

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

Fluorescent probes illuminate the mysteries of GPCRs in cutting-edge research. Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing Join Terry's Corner Today ➤ Celtarys Research – Confocal Imaging That Preserves GPCR Function Confocal community platform to help train and inspire the next generation of scientists. University Attendee Ready to turn ambiguous signals into confident, defensible decisions—and join a community

Meanwhile, researchers in the building across the way turned off the lights at 6 PM. That choice led him to immunology research on pigs — and, eventually, to a PhD. The work introduced him to hormonal signaling, appetite regulation, and cellular communication systems GPCRs Re-Enter the Story — Not as Theory, but as Tools GPCRs have always been powerful drug targets — That partnership eventually produced fluorescent GPCR tools  that allow researchers to visualize GPCR

Interdisciplinary design isn’t optional in GPCR imaging. It’s the catalyst. And the most striking validation came from in vivo GPCR imaging. Strong GPCR imaging tools come from strong interdisciplinary relationships. conversation is part of a three episode series produced in collaboration with our partners at Celtarys Research  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization

GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

Broichhagen aka JB, the goal was bold and elegant: Create a photo-switchable ligand to remotely control GPCR They had a tool that did bind the GPCR… but not in the light-controlled way they wanted. Indirect signaling readouts Researchers in the field know this frustration intimately: an antibody works The Larger Lesson for Scientists and Innovators This story isn’t just about a GPCR imaging tool. conversation is part of a three episode series produced in collaboration with our partners at Celtarys Research

Get ready for an expedition, GPCR explorers! Embark on another exciting exploration of the unknown realms of GPCR research. The 11th Adhesion GPCR Workshop 2024 was a successful event that brought together experts, researchers Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate Research Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation

Why Speed Matters in GPCR Drug Discovery Nine out of ten GPCR programs stall  not because the target How CRO Communication Impacts GPCR Drug Development Success Even the best science falters without operational CRO partnerships are essential for most discovery programs, but they often break down on communication Strategic communication drives momentum. How better CRO communication prevents costly errors. 👉  Join Terry’s Corner & Secure Your Spot for the

Exploring the Hidden Dynamics: How Kinetics Reveals What Equilibrium Conceals in GPCR Research. Hi GPCR Community, If equilibrium curves are your comfort zone, this week’s feature will challenge (and It’s built for the GPCR community—by people who live the science—so you spend less time sifting and more Kenakin is a masterful teacher and communicator." — DrGPCR University Attendee Everything you need to master GPCR science — in one membership. 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research

researchers to quantify cellular responses with spatial, temporal, and mechanistic depth. The resulting multiparametric datasets are well-suited for GPCR research, where receptor trafficking, researchers aiming to reduce ambiguity in early hit-finding, the shift from radioligands to fluorescent For teams working in GPCR pharmacology or cannabinoid research, these tools accelerate hit validation At Celtarys, we remain committed to enabling this transition and supporting researchers as they design

This week's Premium content offers a curated look at what's moving the industry and scientific community GPCR Podcast : The Future of GPCR Drug Discovery with Molecular Modeling The field of GPCR research is This is a critical opportunity for the scientific community to come together and share new findings on Connect with experts:  Join a community of like-minded field-experts dedicated to improving our collective Kenakin) teaming up with the best GPCR community platform to help train and inspire the next generation

Exploring the intracellular allosteric site GPCRs represent one of the largest and most vital families For this reason, GPCRs have been a focus of drug development for decades due to their role in regulating GPCR activity, enabling greater specificity and fewer side effects. Recent advances in structural biology have allowed researchers to visualize the binding of allosteric allosteric site common in class A and class B GPCRs, particularly in chemokine receptors.

Terry’s Corner: GPCR Binding Affinity Experiments That Hold Up Orthosteric GPCR binding affinity experiments GPCR Podcast: When GPCR Tools Scale Even the most elegant tools only matter when they scale beyond a In Episode 3 of 3  of our series with Celtarys Research , leaders from academia and biotech unpack what pathways for academic contributors Launch of The Foundry , supporting strategy and CRO alignment In-person community 👉 Access this week’s full Premium Edition here ➤ Voice of the Community “It’s like being at a GPCR

research from descriptive science into predictive decision-making. GPCR Modeling in Context: Then and Now When Carlsson entered the GPCR field in the early 2000s, structural Why Predictive GPCR Modeling Matters Now The convergence of machine learning, improved GPCR structures But success depends on researchers who can manage expectations, build trust, and integrate across disciplines Want to go deeper into GPCR modeling? Dr.

moments that changed everything. 👉 Discover the pHSense™ Reagents + Listen to the podcast ➤ Celtarys Research A new contributor article from our friends at Celtrays Research outlines how dual-labeled fluorescent GPCR innovation is accelerating. University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers