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Discovering Modeling (and GPCRs) by Accident That interest led him to pursue a thesis at Scripps Research computational environment, and he realized how much he enjoyed the intellectual energy of modeling communities For Carlsson, this marked a shift in how his lab approached GPCR research. He came to see that effective GPCR research requires true interdisciplinary integration. Trainees must learn how to interpret assay data, understand pharmacological context, and communicate

August 2022 "GPCRs modulate a plethora of physiological processes and mediate the effects of one-third The guidelines will aid consistency and clarity, as the basic receptor research and drug discovery communities Read more at the source #DrGPCR #GPCR #IndustryNews

Enhance your GPCR research with deeper assay insights for more effective results. Breakthroughs this week: C. elegans avoids EGCG via SRXA-7 GPCR; a bidirectional GPCR switch modulates Plus: new research on CaSR, leptin signaling, and inflammation-linked GPCRs — and curated roles in computational Become a Premium Member today. ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, field 🧠 Designed for researchers at every career stage

If you’re building tools or careers in GPCR science, this is your playbook. Changed After This Data: Trinquet pushed pHSense toward rapid commercialization—pivoting it from a research GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical tools to accelerate your research or career. 👥 Build connections. 🧪 Get insights. 🎧 Stay ahead.

Before the advent of AlphaFold, homology modeling was the most common method for predicting G protein-coupled receptor (GPCR) structures, especially when experimental data were limited. GPCRs are dynamic, switching between multiple conformations, and many have only distant homologs with The introduction of AlphaFold2 marked a major advancement in the field of GPCR structure prediction. In a recent study on TAAR1, a GPCR linked to central nervous system disorders, researchers compared the

July 2022 Confo Therapeutics receives €1.7 million VLAIO grant for further research on GPCR modulators The grant should help expand Confo Therapeutic’s research on G protein-coupled receptor (GPCR) drug candidates . " Read more at the source #DrGPCR #GPCR #IndustryNews

Before your GPCR ligand ever meets its receptor, it meets the enzymes that determine whether it survives Discovery Program So what does that mean for discovery scientists designing the next generation of GPCR Even the most elegant GPCR ligand can fail if it never reaches its receptor. GPCR members save 50%+  with your Weekly News code. 👉 Join Terry’s Corner & Secure Your Spot for the Kenakin with your own enzyme or GPCR interaction puzzles.

Get ready for an expedition, GPCR explorers! Embark on another exciting exploration of the unknown realms of GPCR research. The 11th Adhesion GPCR Workshop 2024 was a successful event that brought together experts, researchers Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate Research Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation

This week's Premium content offers a curated look at what's moving the industry and scientific community GPCR Podcast : The Future of GPCR Drug Discovery with Molecular Modeling The field of GPCR research is This is a critical opportunity for the scientific community to come together and share new findings on Connect with experts:  Join a community of like-minded field-experts dedicated to improving our collective Kenakin) teaming up with the best GPCR community platform to help train and inspire the next generation

GPCR Forum Start a lively chat or request help with your research! GPCR community members Join the GPCR fan club and geek out with fellows! So much more to come! This change is all about keeping our community strong and delivering top-notch content. It'll help us keep things running smoothly and grow our community. AlloViz: A tool for the calculation and visualisation of protein allosteric communication networks GPTrans

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

The GPCR ship is setting sail on a grand voyage across the vast ocean of research. We are dedicated to enhancing our community and delivering exceptional services to achieve our goal GPCR courses GPCR Forum Start an engaging discussion or request help in your research. GPCR community members Build connections with other GPCR fans :) So much more to come! mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc

Fluorescent probes illuminate the mysteries of GPCRs in cutting-edge research. Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing Join Terry's Corner Today ➤ Celtarys Research – Confocal Imaging That Preserves GPCR Function Confocal community platform to help train and inspire the next generation of scientists. University Attendee Ready to turn ambiguous signals into confident, defensible decisions—and join a community

Why Speed Matters in GPCR Drug Discovery Nine out of ten GPCR programs stall  not because the target How CRO Communication Impacts GPCR Drug Development Success Even the best science falters without operational CRO partnerships are essential for most discovery programs, but they often break down on communication Strategic communication drives momentum. How better CRO communication prevents costly errors. 👉  Join Terry’s Corner & Secure Your Spot for the

Introduction Dopamine receptors are G-protein-coupled receptors (GPCRs), which have 5 subtypes -D1-5. Thus, developing assays for commercially available probes such as CELT-419 would facilitate research Fluorescence anisotropy (FA) assay has been used to study the ligand binding kinetics of many GPCRs.[ For example, a Cy5-labelled fluorescent ligand with the same pharmacophore is available from Celtarys Research methods can increase the quality and quantity of both fundamental receptor research and high-throughput

Exploring the Hidden Dynamics: How Kinetics Reveals What Equilibrium Conceals in GPCR Research. Hi GPCR Community, If equilibrium curves are your comfort zone, this week’s feature will challenge (and It’s built for the GPCR community—by people who live the science—so you spend less time sifting and more Kenakin is a masterful teacher and communicator." — DrGPCR University Attendee Everything you need to master GPCR science — in one membership. 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research

GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

G protein-coupled receptors (GPCRs) are integral membrane proteins crucial for sensing extracellular Despite their immense potential, utilizing FRET and BRET sensors in GPCR research comes with challenges In conclusion, FRET and BRET-based sensors have transformed the landscape of GPCR research, offering unprecedented insights into the intricacies of GPCR signaling. Nature Communications, 2016. 7(1): p. 12178. 11.    Strungs, E.G., L.M. Luttrell, and M.H.

By combining fiber photometry with FRET-based biosensors, we were able to track GPCR-dependent signaling Hence, it has wide applicability across a spectrum of neuroscience research, ranging from the study of Read more at the source #DrGPCR #GPCR #IndustryNews

research from descriptive science into predictive decision-making. GPCR Modeling in Context: Then and Now When Carlsson entered the GPCR field in the early 2000s, structural Why Predictive GPCR Modeling Matters Now The convergence of machine learning, improved GPCR structures But success depends on researchers who can manage expectations, build trust, and integrate across disciplines Want to go deeper into GPCR modeling? Dr.

Exploring the intracellular allosteric site GPCRs represent one of the largest and most vital families For this reason, GPCRs have been a focus of drug development for decades due to their role in regulating GPCR activity, enabling greater specificity and fewer side effects. Recent advances in structural biology have allowed researchers to visualize the binding of allosteric allosteric site common in class A and class B GPCRs, particularly in chemokine receptors.

moments that changed everything. 👉 Discover the pHSense™ Reagents + Listen to the podcast ➤ Celtarys Research A new contributor article from our friends at Celtrays Research outlines how dual-labeled fluorescent GPCR innovation is accelerating. University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already Upcoming events:  GPCR-UK Network Meeting, neuroGPCR symposium, and Transatlantic ECI GPCR event—where Position your research for maximum visibility.   Register for Discovery On Target ➤ What our community is saying “I enjoy the breadth of questioning that GPCR Podcast Listener Why Dr.

Hello GPCR Trailblazers, This week, we’re spotlighting Celtarys Research, our newest partner, featured GPCR will help researchers move faster with custom fluorescent ligands, translational insight, and tool-enabled Introducing Celtarys - Probe Development via Conjugation Strategies   Celtarys Research's first article Explore this week’s research, tools, and biotech insights in one place. The insights are ready. GPCR Team

In GPCR drug discovery, a single mistaken assumption can derail an entire program. Why Misreading Antagonism Delays GPCR Drug Discovery If a dose-response curve shifts to the right, you Common misconceptions  arise when irreversible binding, receptor reserve, or allosteric effects mimic Why now:  GPCR research is accelerating—and the projects that succeed will be those built on clear, accurate

GPCR research requires turning data into insights for drug discovery Hi GPCR Friends, Every week, critical decisions in GPCR research hinge on subtle shifts in data. GPCR Podcast – Ajay Yekkirala on GPCR Innovation In this episode, Dr. Be part of the nonprofit mission to unite the GPCR community. The pace of GPCR innovation is accelerating.

GPCR podcast is now available! Our guest is Mark Schmeizl! Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR cells "β-arrestins mediate regulatory processes for over 800 different G protein-coupled receptors (GPCRs ) by adopting specific conformations that result from the geometry of the GPCR-β-arrestin complex. However, whether β-arrestin1 and 2 respond differently for binding to the same GPCR is still unknown. Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter

GPCR podcast is now available! Our guest is Dr. Adriano Marchese! Learn about his remarkable career and research in #GPCR signaling and trafficking. Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

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