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biasing latrophilins’ regulation of cyclic AMP pathways and for determining the magnitude of ligand selectivity

Why This Matters How lipid raft microdomains selectively regulate GPCR signaling and internalization

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experiments to the specific phase and risk tolerance of the asset De-risk Your CRO Strategy I evaluate, select

Chris Tate's thermostabilization strategy, which introduced stabilizing mutations selected by thermal The acetate-in-the-buffer discovery 41:47 Thirty years in, and the same speakers keep getting the mic Selected

In principle, biased antagonists could selectively block the disease-relevant pathway. But Dr. changed the direction of a lab 47:30 The future of the GPCR superfamily and the work still to be done Selected

That selective cross-reactivity turned the reagent into a visual probe of which receptor-arrestin pairs Selected Quotes "There are more than 800 GPCRs, as you know, but there are only two isoforms of beta-arrestins

He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and

Future of Drug Development 🚀 🔹 By integrating bias into drug design , researchers can craft more selective

Our goal is to develop safer beta2AR-selective ligands for the treatment of asthma and acute rescue therapy

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with Purpose Joe’s personal mission— to make a positive impact on people’s lives —drives their client selection

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self-contained blocks 04:47 The Zoom effect — quieter voices speaking up 05:49 Closing reflections 06:01 Outro Selected

career 12:20 Rotation students as the sorting hat 13:20 When the working hypothesis fails 14:30 Closing Selected

Selected Quotes "If you had asked me in 2008 if I would be a recruiter slash career coach, I didn't even

collaboration with Patrick Sexton and Jim Burch, and the discovery of hybrid molecules with functional selectivity

The aha moment: gut microbes, a GPCR, and blood pressure 39:58 Diversity as everyone's responsibility Selected

infrastructure breaks down at national scale 10:16 Lessons for the next one, and the shape of the new normal Selected

“Let’s embrace the challenge to study all of them… they’re unique in how they bind ligands, how selective

:28 The hidden cost of being the only one in the room 57:05 What the pandemic did to a mouse colony Selected

Selected Quotes "The very simple concept is that GPCRs do not need to be mutated to be oncogenic."

Vaccine development speed and public trust 33:40 Staying sane — pickleball, walking, and community Selected

:43 A weekly release cycle built around user feedback 24:13 Why vaccines still take eighteen months Selected

Selected Quotes "My computational team told me, 'this receptor is not using arrestin to internalize.

Selected Quotes "We tried to look for bias and classify our drugs, new and standard drugs, according

Selected Quotes “The line between drugs and poisons is not so different.”