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drug designed around biased agonism principles received regulatory approval, but its actual functional selectivity He described coaching sessions, national leadership courses, and the deliberate selection of mentors vision for GPCRDB 50:01 Career-defining moments, work-life balance, and advice for junior scientists SELECTED

kinetic roles of RGS and GoLoco proteins Biased agonism at class B GPCRs - ligand-dependent pathway selectivity The insight that G protein regulatory proteins may shape the functional selectivity of GLP-1 agonists collaborations 57:58 Advice for trainees - staying curious, knowing your question, and talking to people Selected

research follows this receptor from the bench to the behaving animal, using optogenetics and circuit-selective Johnson's lab has extended this using conditional knockout mice that allow selective deletion of mGlu2 scientists: let the biology lead the method 35:28 Diversity in STEM and who carries the labor of change SELECTED

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and the transmission of scientific taste — How the values that make a scientist effective — problem selection The strategic logic behind choosing beta-adrenergic receptors The selection of the beta-adrenergic system quiet relief, a pot of coffee, and one phone call to Brian 01:35:54 Work-life balance: an honest answer SELECTED

A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Adam GPCR Function A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity

His work focuses on developing novel β₂-adrenergic ligands that selectively engage signaling pathways Jan Nedergaard, pioneers in thermogenesis research. thermogenesis Skeletal muscle metabolism and glucose homeostasis GPCR signaling complexity and pathway selectivity observation leading to a new drug concept 38:30 Advice for young scientists and intellectual independence Selected

library of libraries as an answer to the diversity ceiling of single phage libraries Greenfield target selection inflammation, metabolism, cardiovascular 24:55 Running a protein engineering team through a pandemic Selected

Why This Matters How lipid raft microdomains selectively regulate GPCR signaling and internalization

research in Drosophila - CRISPR, epitope tagging, and knockout strategies The logic of model organism selection negative results; pressure on PhD timelines 40:54 - Upcoming GPCR conferences in Leipzig and Dusseldorf Selected

He discovered the National Chemistry Olympiad and was selected to attend a provincial training camp at This led to his participation in the National Training Program in Quebec City and his selection to represent

Chris Tate's thermostabilization strategy, which introduced stabilizing mutations selected by thermal The acetate-in-the-buffer discovery 41:47 Thirty years in, and the same speakers keep getting the mic Selected

discovery Trace amine-associated receptors (TAARs) and their neurological relevance Promiscuity and selectivity clinical trials 43:40 Five months of empty crystals 55:56 Rebuilding a research group during lockdown Selected

proteins 11:31 The "dumb luck" of starting on serotonin receptors at NIH 16:43 Studying functional selectivity Selected Quotes "Every GPCR is good for something, basically.

He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and

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experiments to the specific phase and risk tolerance of the asset De-risk Your CRO Strategy I evaluate, select

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In principle, biased antagonists could selectively block the disease-relevant pathway. But Dr. changed the direction of a lab 47:30 The future of the GPCR superfamily and the work still to be done Selected

a fundamentally different kind of science possible Most biobanks require active consent and recruit selected computational career 52:44 - Eureka moment - first hits from 218 peptides screened against orphan receptors Selected

creating the conditions for good science 08:58 - The drug discovery process from pathophysiology to target selection putting yourself out there 01:05:19 - Intuition as hypothesis generator: what comes before the data Selected

That selective cross-reactivity turned the reagent into a visual probe of which receptor-arrestin pairs Selected Quotes "There are more than 800 GPCRs, as you know, but there are only two isoforms of beta-arrestins

Our goal is to develop safer beta2AR-selective ligands for the treatment of asthma and acute rescue therapy

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promising clones early and to hold specificity, scalability, and consistency steady once those clones are selected

sample, and one cold email to a Nobel laureate 01:35:33 Lab openings and where to find the Boucard Lab Selected biasing latrophilins’ regulation of cyclic AMP pathways and for determining the magnitude of ligand selectivity

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Future of Drug Development 🚀 🔹 By integrating bias into drug design , researchers can craft more selective

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