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The reserved indications, where Addex retains exclusive rights to develop its own independent GABAB PAM program, have also been expanded to include chronic cough, in addition to the rights to develop certain

Originally developed as ultra-bright lanthanide probes, the team realized they could tune these molecules Dual control: not just brightness but fluorescence lifetime, with drastic shifts as pH drops.

Those who act on the right signals today will lead tomorrow’s breakthroughs—and avoid delays others won between stalled programs and breakthrough therapies often lies in a single insight delivered at the right

. -            High-throughput applications Bright and stable fluorescent ligands can be used in HTS, Tag brightness and stability:  the brighter and more stable the better the assay outcome. 2.      

and, in this review, we have compared expression of GPCR mRNAs in human islets obtained from normal weight range donors, and those with a weight range classified as obese.

But a pattern emerged: some scaffolds showed dual responsiveness to pH through lifetime and brightness lanthanide probe design with Durham University (chemistry) → Discovery of pH-sensitive dual response (brightness

My work isn't just  about the latest and best assay; it's about the framework that ensures the right assay data leads to the right decision.

Novo Nordisk’s amycretin showed up to 24% weight loss, CagriSema delivered 22.7% in Phase 3, and semaglutide

GIPR biased agonism enhances metabolic outcomes —with dual targeting showing synergistic glucose and weight

Advantages of Fluorescent Ligands in GPCR Drug Screening for CNS Choosing the right tools is important for the success of drug discovery, just as much as choosing the right targets.

The differentially expressed genes (DEGs) and weighted correlation network analysis (WGCNA) were performed

But one academic spark—and the right mentor—changed his trajectory forever.

... and honestly, like with the trials, they were not really that sufficiently better than opioids, right

GPCR Premium is designed for scientists who need the right intelligence, fast—without noise, distractions Those acting on the right signals today will shape tomorrow’s breakthroughs—and avoid delays others won

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Moreover, independent of glucose control or weight loss, the anti-inflammatory actions of GLP-1RAs require

strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary restrictions and weight

Drug efficacy depends on which cells express the receptor Side effects are tied to where agonists bind Weight-loss

Bright illumination triggered Gαt1 translocation from the rod outer to inner segments in all three transgenic

That's right, you're about to level up your knowledge game! keep you on your toes  Direct line to all the cool cats in the GPCR community - Networking is key, right

Overcoming them requires careful assay design and strategic use of the right fluorescent probes. CB 2 -expressing HEK cell lines are labeled with CELT-331 at 80 nM (right), while competition with the

accidental discoveries could revolutionise women’s health Seven unanswered questions about blockbuster weight-loss

Chemokines are low molecular weight proteins that their functional activities are achieved by binding

Right panel, the fluorescent signal is displaced when, after incubating with CELT-327, cells are incubated

translational strategy, this is where 40 years of pharmacological insight meets the questions you’re asking right

How do we prevent lean muscle loss during weight loss?

New generations of fluorophores with improved photostability and brightness will enhance assay sensitivity

Acting on the right signals today shapes tomorrow’s breakthroughs — and prevents delays others won’t

GPCR innovation is accelerating; act on the right signals today to shape tomorrow’s breakthroughs—and

Those acting on the right signals today will shape tomorrow’s breakthroughs—and avoid delays others won