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Hay examines the molecular pharmacology of the calcitonin receptor and calcitonin-like receptor - with on the molecular pharmacology of class B GPCRs - specifically the calcitonin receptor and calcitonin-like partly involve another. mRNA Cannot Tell You Where the Functional Dimer Is For obligatory heterodimers like The Migraine Pharmacology Gap CGRP is elevated in migraine, infused CGRP triggers migraine-like headache

publication records reflect, and Arey is unusually candid about what that obscurity actually feels like hypothesis itself - the moment where you commit to a direction - comes from something that looks more like I feel like as scientists, we should be who we are. Just because I don't act like somebody else doesn't mean I'm not a good scientist.

are saying about this podcast "You made it a very comfortable and engaging experience, and it felt like I've listened to the episodes multiple times and it's just like being at a conference getting new ideas

Caron at Duke University. Dr. advocate for trainees at all levels, she served as Service Chairperson and Interim President of the Duke

In his words: “She let me run projects like a junior PI.” and CNS-associated ones—are often downplayed in pain research, with most focus on ionotropic targets like “She [Vanna] gave me a crash course in what it’s like to be a junior PI.

By working with distinct chemical scaffolds like thiazolidines and xanthinediones, Ben is helping define Pharmacology Despite the availability of modern tools, Ben stresses the enduring value of classical methods like At Michigan, his lab balances rigor with light-hearted engagement — like daily squirrel trivia on their

with Conformational dynamics as functional evidence — how biosensors are being used to argue for GPCR-like small molecules, repurposed Smoothened compounds, and what a druggable frizzled might eventually look like identity 01:03:11 Career advice: explore widely, then commit to a niche Selected Quotes "The frizzles look like "It's not like in the good old adenosine receptor times, that we have the small molecule available and

The lab’s early partnership with students like Emily Lorenzen catalyzed a transition from single-receptor They can be used to probe GPCR associations with any protein , from cytoskeletal scaffolds like 14-3- team envisions using these tools to detect GPCR autoantibodies , which are implicated in conditions like

highlighted his mentors' influence, such as Fred Mitchelson and Nigel Burch, and significant discoveries like strategies for analyzing large compound screening data, emphasizing robust assays and addressing issues like They also discussed the potential of certain drugs, like flumazenil, as 'nails' or compounds that could

What looked like duplication was nature using bias for fine tuning. He is unusually plain about what this felt like: not the relief of finally seeing, but the recognition them drugs - 05:45 Why research is a privilege rather than a reward for good marks - 08:37 Thinking like

executed a PhD entirely in the industry setting—efficient, targeted, and rooted in real-world projects like Lessons from Molecules and Mentors He draws inspiration from scientific complexity and colleagues like

crystallography could never access Class D GPCR architecture - what a dimer with no prior blueprint looks like Science requires a skin like a rhino Tate's advice to young scientists is not procedural - it is temperamental You have to be robust, you have to have a skin like a rhino sometimes."

GPCR University See what it feels like to have a professional home in GPCR science 14 days. For 14 days, you're not testing — you're experiencing what it's like to have a professional home in GPCR

opioid receptor pharmacology, and the challenges of discovering ligands for understudied receptors like membrane protein structural biology. 10:00 — Pursuing challenging scientific problems Why difficult fields like I would like to remain in drug discovery , ideally working on GPCRs if possible. Yamina Berchiche: That sounds like an exciting direction. It’s completely normal to feel intimidated when entering a complex field like GPCR biology.

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You can also collect and store information from your site visitors using input elements like custom forms

You can also collect and store information from your site visitors using input elements like custom forms

I would like to keep working in the central nervous system disorders realm to understand the neurobiology

targets are especially difficult to immunize against, how receptor family homology between targets like makes immunogen selection a critical and underappreciated decision point, and what it actually looks like Chemokine receptors like CXCR1 and CXCR2 share over 75% sequence identity - use the wrong peptide region

presynaptic adrenergic receptors in hypertension, and his postdoctoral training with Bob Lefkowitz at Duke trajectory 12:06 The meaning of unexpected data and what it signals about discovery 14:49 Arriving at Duke Ph.D. in Neurological Sciences at the same university in 1985, he completed a post-doctoral fellow at Duke

Upon receptor-mediated endocytosis, the probe is internalized into acidic intracellular compartments (like Intracellular Signaling Track key downstream events like ERK, AKT, and CREB phosphorylation with high-throughput All four formats are validated in well-established models like GLP1R and Mu opioid receptor (MOR), and

We moved to Salt Lake City, Utah in 2020 to begin his own laboratory in the Department of Biochemistry

Both Chuck and Joe agree: accounting is like solving puzzles. They avoid companies that don’t align with their values, like the vaping industry.

of careful record-keeping on assays that never worked, from adhesion GPCRs to certain photoreceptor-like I like to call myself a jack of all trades, maybe master of none, but enough to be dangerous.

In my free time I like to play the guitar, sing and play board games. " Gáspár Pándy-Szekeres on the

participated and initiated methodologies for development of pharmacologically active anti-GPCR antibodies like

to earn a Ph.D. in Molecular Biophysics from Johns Hopkins University, followed by postdocs at both Duke

Back to podcast list Strategic Partner(s) Chloe Hicks About Chloe Hicks Chloe Hicks will graduate from Duke

Introduction Glucagon-like peptide-1 (GLP-1) is an incretin hormone that plays a central role in the