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Get your space suits on, GPCR cadets! The GPCR rocket is all fueled and ready to blast off into a galaxy of incredible advancements, now powered up with a series of cosmic GPCR events for the year ahead. It’s time to mark your calendars and save the dates—let’s make some stellar memories together! 🚀✨ This Week’s Highlights: Congrats to: Ya-Tzu Li , our notable contributor, for her superb undergrad paper along with Hao-Jen Hsu , Chun-Chun Chang , et al.   about State transitions of coupled Gi-protein: Insights into internal water channel dynamics within dopamine receptor D3 from in silico submolecular analyses Joseph Crecelius , Adriano Marchese , et al. for their excellent work on Receptor determinants for ß-arrestin functional specificity at C-X-C chemokine receptor 5 (CXCR5) Panjamaporn Sangwung , Alejandra Tomas , Kyle Sloop , et al. for their outstanding study on Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease Milena Malcharek , Graham Ladds , et al. for their extensive research on The role of receptor activity-modifying proteins in obesity and diabetes mellitus Maleesha Ubhayarathna , Christopher Langmead , Gregory Stewart , et al. for their fantastic review on Molecular and structural insights into the 5-HT2C receptor as a therapeutic target for substance use disorders Leigh Walker , Christopher Langmead , Andrew Lawrence , et al. for their remarkable analysis on Targeting muscarinic receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development 👨‍💻 Why would you want to miss out on all the fun with a DrGPCR Premium Membership ? Being a premium member means you get to enjoy all the freebies plus: Access to the recorded classes of GPCR Courses . That's right, you're about to level up your knowledge game! Discounted GPCR courses - because who doesn't love a good deal?  Exclusive access to private groups  Over 30 recorded talks from Symposia - that's a lot of brain food!  Job listings for candidates and positions to connect! Exciting event listings to keep you on your toes  Direct line to all the cool cats in the GPCR community - Networking is key, right?  Big Update! From 2025, only Premium Members will have access to Classified GPCR News. This transition will enable us to invest in higher-quality content and resources, ensuring our community gets the very best insights and updates! Classified GPCR News  Let’s dive into the   Classified GPCR News from October 28th to November 3rd, 2024 Industry News Nxera Pharma Operational Highlights and Consolidated Results for the Third Quarter and First Nine Months of 2024 Nasdaq debutante Septerna swells its IPO to $331m Nxera Pharma and Antiverse Enter Collaboration To Design Novel GPCR- Targeted Antibody Therapeutics Using Generative AI Zombie Fungi Hijack Hosts’ Brains GPCR Therapeutics, Inc. has received Orphan Drug Designation (ODD) from the FDA for its hematopoietic stem cell mobilization agent It’s not just obesity. Drugs like Ozempic will change the world GPCR Events, Meetings, and Webinars November 5 - 7, 2024 | 16th Annual PEGS Europe   NEW November 25 - 26, 2024 | 6th International Conference on Stem Cell, Tissue Engineering and Regenerat November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe NEW December 10 - 12, 2024 | Pharmacology 2024 NEW January 13 - 16, 2025 | PepTalk 2025 NEW January 25 - 29, 2025 | SLAS 2025 NEW February 15 - 16, 2025 | Structural and Functional Approaches in GPCR Drug Discovery NEW February 15 - 19, 2025 | BPS 2025 NEW February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery NEW March 12 - 14, 2025 | NextGen Biomed 2025 NEW March 25 - 28, 2025 | 10th German Pharm-Tox Summit NEW April 1 - 5, 2025 | XXIII GEM Meeting in 2025 NEW April 3 - 6, 2025 | ASPET 2025 NEW   April 14 - 17, 2025 | 20th Drug Discovery Chemistry NEW   April 24 - 27, 2025 | American Physiology Summit 2025 NEW April 25 - 30, 2025 | AACR Annual Meeting 2025 NEW May 12 - 15, 2025 | PEGS 2025 NEW May 20 - 22, 2025 | SLAS Europe 2025 NEW June 16 - 19, 2025 | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry GPCR Activation and Signaling GPCR signalling: Yet another variant route in a highly complex road map Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors Receptor determinants for ß-arrestin functional specificity at C-X-C chemokine receptor 5 (CXCR5) State transitions of coupled Gi-protein: Insights into internal water channel dynamics within dopamine receptor D3 from in silico submolecular analyses GPCRs in Cardiology, Endocrinology, and Taste Adipose tissue in older individuals: a contributing factor to sarcopenia Asprosin regulates male reproduction in teleosts: an in vitro study in Channa punctata GPCRs in Neuroscience Neuron specific quantitation of Gαolf expression and signaling in murine brain tissue Regulator of G protein signaling 6 (RGS6) in dopamine neurons promotes EtOH seeking, behavioral reward, and susceptibility to relapse GPCRs in Oncology and Immunology The GPCR adaptor protein Norbin controls the trafficking of C5aR1 and CXCR4 in mouse neutrophils Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor Reviews, GPCRs, and more Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease The role of receptor activity-modifying proteins in obesity and diabetes mellitus Molecular and structural insights into the 5-HT2C receptor as a therapeutic target for substance use disorders Targeting muscarinic receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development Chemokine CXCL13-CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases Structural and Molecular Insights into GPCR Function Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM structure determination Molecular Basis of MC1R Activation: Mutation-Induced Alterations in Structural Dynamics Molecular determinants of neuropeptide-mediated activation mechanisms in tachykinin NK1 and NK2 receptors Become a Premium Member! 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Good day readers! This week we’ve curated 20 GPCR papers, 3 new events, 9 industry news, and 3 job opportunities! Discover our comprehensive coverage of GPCRs, We welcome GPCR paper suggestions! Submit your publications to Hello@DrGPCR.com for consideration. This week's highlight: Dr. Matthew T Eddy and his team's research on A2A adenosine receptor activation by G protein and mutations. Are you looking to hire? Or maybe looking for your next opportunity? Our Chief Matchmaker, Mark Schmeizl, is here to assist you. Simply complete this form to get in touch with him. November Dr. GPCR Newsletter is out now. Subscribe for this month's video featuring Dr. Alix Rouault. Ensure to catch the upcoming episodes of Dr. GPCR Podcast featuring Dr. Neil Grimsey and Dr. Katarzyna Marcinkiewicz. Be sure to look at the Classified GPCR News from November 27th to December 3rd, 2023. GPCR Activation and Signaling DANGER Signals Activate G -Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma Single-molecule visualization of human A2A adenosine receptor activation by a G protein and constitutively activating mutations Distinct activation mechanisms of β-arrestin-1 revealed by 19F NMR spectroscopy Role of protease activated receptor 4 (PAR4) in mouse models of acute and chronic kidney injury GPCR Binders, Drugs, and more High-throughput virtual screening of potential inhibitors of GPR52 using docking and biased sampling method for Huntington's disease therapy Rational design of highly stabilized and selective adrenomedullin analogs Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation Flavonoids as G Protein-coupled Receptors Ligands: New Potential Therapeutic Natural Drugs GPCRs in Cardiology, Endocrinology, and Taste Phenylacetyl glutamine (PAGln) enhances cardiomyocyte death after myocardial infarction through β1 adrenergic receptor Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis GPCRs in Neuroscience Targeting sensory neuron GPCRs for peripheral neuropathic pain GPCRs in Oncology and Immunology Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis Methods & Updates in GPCR Research Modulating signalling lifetime to optimise a prototypical animal opsin for optogenetic applications Imaging flow cytometry of tumoroids: A new method for studying GPCR expression GPCR molecular dynamics forecasting using recurrent neural networks A method for multiple-sequence-alignment-free protein structure prediction using a protein language model Reviews, GPCRs, and more Potential of olfactory neuroepithelial cells as a model to study schizophrenia: A focus on GPCRs (Review) Structural and Molecular Insights into GPCR Function Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein complex Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors Industry News Sosei Heptares to take back GPCR agonist after GSK changes course All-rounder among receptors inspires drug research Tectonic Therapeutic Announces Start of First Clinical Program for GPCR-Targeted Biologic Trevena Announces Acceptance of Abstract Examining the Use of OLINVYK in Patients with Acute Burn Injuries Carmot Therapeutics Enters into Definitive Merger Agreement with Roche New Clinical Trial Explores Novel Target In Parkinson’s Treatment GPCR Events, Meetings, and Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition February 11 - 14, 2023 | 2024 BPS Annual Meeting March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines NEW June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks NEW June 25 - 29, 2024 | FENS Forum 2024 October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry NEW October 23 - 25, 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Principal scientist – oncology biomarker expert NEW Postdoctoral Fellow NEW Scientific Assistant Scientist Lead Researcher Post-Doctoral Fellow Sr Scientist in Obesity, Muscle, and Metabolism Post-Doctoral Fellow Explore Dr. GPCR Ecosystem

Breakthroughs this week: Decoding ADGRE5 signaling; Eli Lilly’s obesity pill vs Novo’s Wegovy; Certa GPCRs in the spotlight; receptor motion tracking tools; obesity treatment race between Eli Lilly and Novo

Biologics announce manufacturing agreement  to advance novel anti-CCR8 antibody  for cancer immunotherapy Novo

Therapeutics with Generative AI Nxera Pharma receives approval of insomnia drug in Japan Lilly and Novo and UK and Announces the Nomination of Clinical Candidate Against MC2 Call for GPCR Papers Deadline: Nov

Industry insights:  Fresh selectivity datasets on openMe; Novo’s obesity dominance faces new challengers

31 December 2022 Addex Raises $5.0 Million in Equity Financing Testing the limits of SMILES-based de novo

De novo drug design: AI algorithms can generate new molecules with desired properties, such as binding

The research team, led by Brandon Novy and colleagues, utilized an innovative APEX2/AUR biosensor that